EsturgeonV1, PubMed, Corpus, bibRecord, 000237

Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.

Identifieur interne : 000237 ( PubMed/Corpus ); précédent : 000236; suivant : 000238

Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.

Auteurs : Janet Genz ; Benjamin Carriere ; W Gary Anderson

Source :

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology [ 1531-4332 ] ; 2013.

RBID : pubmed:23831300

English descriptors

KwdEn :
- Animals, Calcium (metabolism), Calcium Channel Blockers (pharmacology), Fishes (metabolism), In Vitro Techniques, Intestinal Absorption, Intestines (drug effects), Intestines (metabolism), Osmolar Concentration, Ruthenium Red (pharmacology), Trifluoperazine (pharmacology).
MESH :
- chemical , metabolism : Calcium.
- chemical , pharmacology : Calcium Channel Blockers, Ruthenium Red, Trifluoperazine.
- drug effects : Intestines.
- metabolism : Fishes, Intestines.
- Animals, In Vitro Techniques, Intestinal Absorption, Osmolar Concentration.

Abstract

Rapid growth in juvenile fish increases calcium demand, and the intestine may play a role in calcium homeostasis at this life stage, in addition to branchial and renal transport. This study examined calcium flux in the gastrointestinal tract (GIT) of freshwater juvenile lake sturgeon acclimated to 0.14, 0.34, and 2.26mmol L(-1) environmental calcium. Net Ca(2+) flux did not differ due to environmental [Ca(2+)] in either the anterior or posterior intestine. Blocking the apical epithelial calcium channel (ECaC) with ruthenium red (RR, 8.5μmol L(-1)) significantly decreased Ca(2+) influx in the anterior intestine, but exposure to the plasma membrane Ca(2+)-ATP-ase (PMCA) inhibitor trifluoperazine (TFP, 10mmol L(-1)) had no effect at any environmental [Ca(2+)], nor did inhibition of the Na(+)-Ca(2+) exchanger (NCX) with KB-R7943 (10μmol L(-1)). Neither RR nor TFP affected Ca(2+) uptake by the posterior intestine in any of the treatment groups, but KB-R7943 reduced net calcium flux in the posterior intestine at all environmental [Ca(2+)]. Thus, basolateral Ca(2+) influx in the posterior GIT of lake sturgeon relies more heavily on NCX than PMCA. Furthermore, the differing pharmacological effects in the anterior and posterior intestine suggest that the dominant transporters responsible for calcium uptake vary over the length of the GIT in lake sturgeon.

DOI: 10.1016/j.cbpa.2013.06.033
PubMed: 23831300

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pubmed:23831300

Le document en format XML

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<author><name sortKey="Genz, Janet" sort="Genz, Janet" uniqKey="Genz J" first="Janet" last="Genz">Janet Genz</name>
<affiliation><nlm:affiliation>Department of Biology, University of West Georgia, Carrollton, GA 30118, USA. jgenz@westga.edu</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carriere, Benjamin" sort="Carriere, Benjamin" uniqKey="Carriere B" first="Benjamin" last="Carriere">Benjamin Carriere</name>
</author>
<author><name sortKey="Anderson, W Gary" sort="Anderson, W Gary" uniqKey="Anderson W" first="W Gary" last="Anderson">W Gary Anderson</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.</title>
<author><name sortKey="Genz, Janet" sort="Genz, Janet" uniqKey="Genz J" first="Janet" last="Genz">Janet Genz</name>
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<author><name sortKey="Carriere, Benjamin" sort="Carriere, Benjamin" uniqKey="Carriere B" first="Benjamin" last="Carriere">Benjamin Carriere</name>
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<author><name sortKey="Anderson, W Gary" sort="Anderson, W Gary" uniqKey="Anderson W" first="W Gary" last="Anderson">W Gary Anderson</name>
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<series><title level="j">Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</title>
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<term>Calcium (metabolism)</term>
<term>Calcium Channel Blockers (pharmacology)</term>
<term>Fishes (metabolism)</term>
<term>In Vitro Techniques</term>
<term>Intestinal Absorption</term>
<term>Intestines (drug effects)</term>
<term>Intestines (metabolism)</term>
<term>Osmolar Concentration</term>
<term>Ruthenium Red (pharmacology)</term>
<term>Trifluoperazine (pharmacology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Calcium Channel Blockers</term>
<term>Ruthenium Red</term>
<term>Trifluoperazine</term>
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<term>Intestines</term>
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<front><div type="abstract" xml:lang="en">Rapid growth in juvenile fish increases calcium demand, and the intestine may play a role in calcium homeostasis at this life stage, in addition to branchial and renal transport. This study examined calcium flux in the gastrointestinal tract (GIT) of freshwater juvenile lake sturgeon acclimated to 0.14, 0.34, and 2.26mmol L(-1) environmental calcium. Net Ca(2+) flux did not differ due to environmental [Ca(2+)] in either the anterior or posterior intestine. Blocking the apical epithelial calcium channel (ECaC) with ruthenium red (RR, 8.5μmol L(-1)) significantly decreased Ca(2+) influx in the anterior intestine, but exposure to the plasma membrane Ca(2+)-ATP-ase (PMCA) inhibitor trifluoperazine (TFP, 10mmol L(-1)) had no effect at any environmental [Ca(2+)], nor did inhibition of the Na(+)-Ca(2+) exchanger (NCX) with KB-R7943 (10μmol L(-1)). Neither RR nor TFP affected Ca(2+) uptake by the posterior intestine in any of the treatment groups, but KB-R7943 reduced net calcium flux in the posterior intestine at all environmental [Ca(2+)]. Thus, basolateral Ca(2+) influx in the posterior GIT of lake sturgeon relies more heavily on NCX than PMCA. Furthermore, the differing pharmacological effects in the anterior and posterior intestine suggest that the dominant transporters responsible for calcium uptake vary over the length of the GIT in lake sturgeon.</div>
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<Title>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</Title>
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<Abstract><AbstractText>Rapid growth in juvenile fish increases calcium demand, and the intestine may play a role in calcium homeostasis at this life stage, in addition to branchial and renal transport. This study examined calcium flux in the gastrointestinal tract (GIT) of freshwater juvenile lake sturgeon acclimated to 0.14, 0.34, and 2.26mmol L(-1) environmental calcium. Net Ca(2+) flux did not differ due to environmental [Ca(2+)] in either the anterior or posterior intestine. Blocking the apical epithelial calcium channel (ECaC) with ruthenium red (RR, 8.5μmol L(-1)) significantly decreased Ca(2+) influx in the anterior intestine, but exposure to the plasma membrane Ca(2+)-ATP-ase (PMCA) inhibitor trifluoperazine (TFP, 10mmol L(-1)) had no effect at any environmental [Ca(2+)], nor did inhibition of the Na(+)-Ca(2+) exchanger (NCX) with KB-R7943 (10μmol L(-1)). Neither RR nor TFP affected Ca(2+) uptake by the posterior intestine in any of the treatment groups, but KB-R7943 reduced net calcium flux in the posterior intestine at all environmental [Ca(2+)]. Thus, basolateral Ca(2+) influx in the posterior GIT of lake sturgeon relies more heavily on NCX than PMCA. Furthermore, the differing pharmacological effects in the anterior and posterior intestine suggest that the dominant transporters responsible for calcium uptake vary over the length of the GIT in lake sturgeon.</AbstractText>
<CopyrightInformation>© 2013 Elsevier Inc. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Genz</LastName>
<ForeName>Janet</ForeName>
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<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>W Gary</ForeName>
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Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.

Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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