Mitochondrial DNA length variation and heteroplasmy in populations of white sturgeon (Acipenser transmontanus).
Identifieur interne : 000674 ( PubMed/Checkpoint ); précédent : 000673; suivant : 000675Mitochondrial DNA length variation and heteroplasmy in populations of white sturgeon (Acipenser transmontanus).
Auteurs : J R Brown [Canada] ; A T Beckenbach ; M J SmithSource :
- Genetics [ 0016-6731 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Mitochondrial.
- chemical : DNA Probes.
- genetics : Fishes, Polymorphism, Genetic.
- Animals, Base Sequence, Blotting, Southern, Genotype, Molecular Sequence Data, Phylogeny.
Abstract
Southern blot analysis was used to quantify the extent of mtDNA D-loop length variation in two populations of white sturgeon, Acipenser transmontanus. Over 42% of individuals were heteroplasmic for up to six different mtDNA length variants attributable to varying copy numbers of an 82-bp repeat sequence. Chi-square analyses revealed that the frequencies of length genotypes and the incidence of heteroplasmy were significantly different between Fraser and Columbia River sturgeon populations but not between restriction site haplotypes. Heteroplasmic fish have, on average, higher copy number than homoplasmic fish. Forty-five of 101 homoplasmic individuals carry only a single copy of the repeat, while none of the 73 heteroplasmic fish has the single repeat as the predominant variant. On the basis of differences in frequency distributions of copy number within and between fish, we suggest that (1) heteroplasmy is maintained by high recurrent mutation of multiple copy genomes, favoring increased copy number and (2) the mutation pressure toward higher copy number heteroplasmy is partially offset by selection to reduced genome size and segregation to the homoplasmic condition.
PubMed: 1398055
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Over 42% of individuals were heteroplasmic for up to six different mtDNA length variants attributable to varying copy numbers of an 82-bp repeat sequence. Chi-square analyses revealed that the frequencies of length genotypes and the incidence of heteroplasmy were significantly different between Fraser and Columbia River sturgeon populations but not between restriction site haplotypes. Heteroplasmic fish have, on average, higher copy number than homoplasmic fish. Forty-five of 101 homoplasmic individuals carry only a single copy of the repeat, while none of the 73 heteroplasmic fish has the single repeat as the predominant variant. On the basis of differences in frequency distributions of copy number within and between fish, we suggest that (1) heteroplasmy is maintained by high recurrent mutation of multiple copy genomes, favoring increased copy number and (2) the mutation pressure toward higher copy number heteroplasmy is partially offset by selection to reduced genome size and segregation to the homoplasmic condition.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1398055</PMID><DateCreated><Year>1992</Year><Month>11</Month><Day>03</Day></DateCreated><DateCompleted><Year>1992</Year><Month>11</Month><Day>03</Day></DateCompleted><DateRevised><Year>2010</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0016-6731</ISSN><JournalIssue CitedMedium="Print"><Volume>132</Volume><Issue>1</Issue><PubDate><Year>1992</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Genetics</Title><ISOAbbreviation>Genetics</ISOAbbreviation></Journal><ArticleTitle>Mitochondrial DNA length variation and heteroplasmy in populations of white sturgeon (Acipenser transmontanus).</ArticleTitle><Pagination><MedlinePgn>221-8</MedlinePgn></Pagination><Abstract><AbstractText>Southern blot analysis was used to quantify the extent of mtDNA D-loop length variation in two populations of white sturgeon, Acipenser transmontanus. Over 42% of individuals were heteroplasmic for up to six different mtDNA length variants attributable to varying copy numbers of an 82-bp repeat sequence. Chi-square analyses revealed that the frequencies of length genotypes and the incidence of heteroplasmy were significantly different between Fraser and Columbia River sturgeon populations but not between restriction site haplotypes. Heteroplasmic fish have, on average, higher copy number than homoplasmic fish. Forty-five of 101 homoplasmic individuals carry only a single copy of the repeat, while none of the 73 heteroplasmic fish has the single repeat as the predominant variant. On the basis of differences in frequency distributions of copy number within and between fish, we suggest that (1) heteroplasmy is maintained by high recurrent mutation of multiple copy genomes, favoring increased copy number and (2) the mutation pressure toward higher copy number heteroplasmy is partially offset by selection to reduced genome size and segregation to the homoplasmic condition.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beckenbach</LastName><ForeName>A T</ForeName><Initials>AT</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>M J</ForeName><Initials>MJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Genetics</MedlineTA><NlmUniqueID>0374636</NlmUniqueID><ISSNLinking>0016-6731</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015342">DNA Probes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004272">DNA, Mitochondrial</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 1989 Sep;6(5):539-45</RefSource><PMID Version="1">2677600</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Methods Enzymol. 1980;65(1):363-71</RefSource><PMID Version="1">7374459</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1985 Jun 21;228(4706):1446-8</RefSource><PMID Version="1">17814488</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 1991 Sep;129(1):247-55</RefSource><PMID Version="1">1682213</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1991 Jul 18;352(6332):255-7</RefSource><PMID Version="1">1857422</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 1990 Jan;124(1):157-63</RefSource><PMID Version="1">1968410</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 1990 Nov;126(3):657-63</RefSource><PMID Version="1">2249764</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Biochem. 1990 Dec 12;194(2):561-71</RefSource><PMID Version="1">2269281</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 1989 Dec;123(4):825-36</RefSource><PMID Version="1">2612897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1981 Oct;78(10):6116-20</RefSource><PMID Version="1">6273850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1983 Nov;80(22):6942-6</RefSource><PMID Version="1">6316335</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1986 Nov;83(22):8813-7</RefSource><PMID Version="1">16578797</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015139" MajorTopicYN="N">Blotting, Southern</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015342" MajorTopicYN="N">DNA Probes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004272" MajorTopicYN="N">DNA, Mitochondrial</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005399" MajorTopicYN="N">Fishes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1205119</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1398055</ArticleId><ArticleId IdType="pmc">PMC1205119</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Beckenbach, A T" sort="Beckenbach, A T" uniqKey="Beckenbach A" first="A T" last="Beckenbach">A T Beckenbach</name><name sortKey="Smith, M J" sort="Smith, M J" uniqKey="Smith M" first="M J" last="Smith">M J Smith</name></noCountry><country name="Canada"><noRegion><name sortKey="Brown, J R" sort="Brown, J R" uniqKey="Brown J" first="J R" last="Brown">J R 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