Binding affinities of hepatic nuclear estrogen receptors for phytoestrogens in rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baeri).
Identifieur interne : 000575 ( PubMed/Checkpoint ); précédent : 000574; suivant : 000576Binding affinities of hepatic nuclear estrogen receptors for phytoestrogens in rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baeri).
Auteurs : K. Latonnelle [France] ; A. Fostier ; Françoise Le Menn [France] ; C. Bennetau-PelisseroSource :
- General and comparative endocrinology [ 0016-6480 ] ; 2002.
English descriptors
- KwdEn :
- Animals, Binding, Competitive, Estradiol (metabolism), Estrogens, Non-Steroidal (metabolism), Female, Fishes (metabolism), Genistein (metabolism), Isoflavones (metabolism), Liver (metabolism), Oncorhynchus mykiss (metabolism), Phytoestrogens, Plant Preparations, Receptors, Cytoplasmic and Nuclear (metabolism), Receptors, Estrogen (metabolism), Vitellogenins (biosynthesis).
- MESH :
- chemical , biosynthesis : Vitellogenins.
- chemical , metabolism : Estradiol, Estrogens, Non-Steroidal, Genistein, Isoflavones, Receptors, Cytoplasmic and Nuclear, Receptors, Estrogen.
- metabolism : Fishes, Liver, Oncorhynchus mykiss.
- Animals, Binding, Competitive, Female, Phytoestrogens, Plant Preparations.
Abstract
Phytoestrogens are dietary estrogenic contaminants capable of inducing vitellogenin synthesis in rainbow trout and Siberian sturgeon. A competitive-binding assay on their hepatic estrogen receptors (ER) was performed to determine the relative affinity of phytoestrogens compared to estradiol (E(2)). Phytoestrogen concentrations used were 1000 times higher than for E(2), except for genistein and formononetin. For each compound, the competition with 50%-bound labelled E(2) (DC(50)) was considered in order to classify phytoestrogens according to their affinity for ER. The affinities are compared for each species. In rainbow trout, estradiol (DC(50): 7 nM)>formononetin (DC(50): 260 nM)>genistein (DC(50): 570 nM)>equol (DC(50): 5.3 microM)>daidzein (DC(50): 9 microM)>biochanin A (DC(50): 100 microM). In sturgeon, estradiol (DC(50): 5 nM)>genistein (DC(50): 220)>formononetin (DC(50): 1 microM)>equol>(DC(50): 8.3 microM)>daidzein>(DC(50): 80 microM)>biochanin A (DC(50): 100 microM). These results demonstrate that phytoestrogens, mimicking estradiol, can disturb the endocrine system by competing for ER. Also, the higher sensitivity to genistein observed in vivo in Siberian sturgeon (vitellogenin synthesis), compared to rainbow trout, is not due to a higher affinity of genistein for the hepatic ER. Thus, the metabolism of phytoestrogen could be species dependent and affect sensitivity.
PubMed: 12441116
Affiliations:
- France
- Aquitaine, Nouvelle-Aquitaine
- Bordeaux, Talence
- Université Bordeaux I, Université de Bordeaux
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:12441116Le document en format XML
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Latonnelle</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génomique et Physiologie des Poissons, Université Bordeaux I, 33405, Talence Cedex, France. k-gontier@enitab.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génomique et Physiologie des Poissons, Université Bordeaux I, 33405, Talence Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName><orgName type="university">Université Bordeaux I</orgName></affiliation></author><author><name sortKey="Fostier, A" sort="Fostier, A" uniqKey="Fostier A" first="A" last="Fostier">A. Fostier</name></author><author><name sortKey="Le Menn, F" sort="Le Menn, F" uniqKey="Le Menn F" first="F" last="Le Menn">Françoise Le Menn</name><affiliation><country>France</country><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university" n="3">Université Bordeaux I</orgName><orgName type="institution" wicri:auto="newGroup">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Bennetau Pelissero, C" sort="Bennetau Pelissero, C" uniqKey="Bennetau Pelissero C" first="C" last="Bennetau-Pelissero">C. 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Latonnelle</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génomique et Physiologie des Poissons, Université Bordeaux I, 33405, Talence Cedex, France. k-gontier@enitab.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génomique et Physiologie des Poissons, Université Bordeaux I, 33405, Talence Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName><orgName type="university">Université Bordeaux I</orgName></affiliation></author><author><name sortKey="Fostier, A" sort="Fostier, A" uniqKey="Fostier A" first="A" last="Fostier">A. Fostier</name></author><author><name sortKey="Le Menn, F" sort="Le Menn, F" uniqKey="Le Menn F" first="F" last="Le Menn">Françoise Le Menn</name><affiliation><country>France</country><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="university" n="3">Université Bordeaux I</orgName><orgName type="institution" wicri:auto="newGroup">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Bennetau Pelissero, C" sort="Bennetau Pelissero, C" uniqKey="Bennetau Pelissero C" first="C" last="Bennetau-Pelissero">C. Bennetau-Pelissero</name></author></analytic><series><title level="j">General and comparative endocrinology</title><idno type="ISSN">0016-6480</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Binding, Competitive</term><term>Estradiol (metabolism)</term><term>Estrogens, Non-Steroidal (metabolism)</term><term>Female</term><term>Fishes (metabolism)</term><term>Genistein (metabolism)</term><term>Isoflavones (metabolism)</term><term>Liver (metabolism)</term><term>Oncorhynchus mykiss (metabolism)</term><term>Phytoestrogens</term><term>Plant Preparations</term><term>Receptors, Cytoplasmic and Nuclear (metabolism)</term><term>Receptors, Estrogen (metabolism)</term><term>Vitellogenins (biosynthesis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Vitellogenins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Estradiol</term><term>Estrogens, Non-Steroidal</term><term>Genistein</term><term>Isoflavones</term><term>Receptors, Cytoplasmic and Nuclear</term><term>Receptors, Estrogen</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fishes</term><term>Liver</term><term>Oncorhynchus mykiss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Binding, Competitive</term><term>Female</term><term>Phytoestrogens</term><term>Plant Preparations</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Phytoestrogens are dietary estrogenic contaminants capable of inducing vitellogenin synthesis in rainbow trout and Siberian sturgeon. A competitive-binding assay on their hepatic estrogen receptors (ER) was performed to determine the relative affinity of phytoestrogens compared to estradiol (E(2)). Phytoestrogen concentrations used were 1000 times higher than for E(2), except for genistein and formononetin. For each compound, the competition with 50%-bound labelled E(2) (DC(50)) was considered in order to classify phytoestrogens according to their affinity for ER. The affinities are compared for each species. In rainbow trout, estradiol (DC(50): 7 nM)>formononetin (DC(50): 260 nM)>genistein (DC(50): 570 nM)>equol (DC(50): 5.3 microM)>daidzein (DC(50): 9 microM)>biochanin A (DC(50): 100 microM). In sturgeon, estradiol (DC(50): 5 nM)>genistein (DC(50): 220)>formononetin (DC(50): 1 microM)>equol>(DC(50): 8.3 microM)>daidzein>(DC(50): 80 microM)>biochanin A (DC(50): 100 microM). These results demonstrate that phytoestrogens, mimicking estradiol, can disturb the endocrine system by competing for ER. Also, the higher sensitivity to genistein observed in vivo in Siberian sturgeon (vitellogenin synthesis), compared to rainbow trout, is not due to a higher affinity of genistein for the hepatic ER. Thus, the metabolism of phytoestrogen could be species dependent and affect sensitivity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12441116</PMID><DateCreated><Year>2002</Year><Month>11</Month><Day>20</Day></DateCreated><DateCompleted><Year>2003</Year><Month>05</Month><Day>20</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0016-6480</ISSN><JournalIssue CitedMedium="Print"><Volume>129</Volume><Issue>2</Issue><PubDate><Year>2002</Year><Month>Nov</Month></PubDate></JournalIssue><Title>General and comparative endocrinology</Title><ISOAbbreviation>Gen. Comp. 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In rainbow trout, estradiol (DC(50): 7 nM)>formononetin (DC(50): 260 nM)>genistein (DC(50): 570 nM)>equol (DC(50): 5.3 microM)>daidzein (DC(50): 9 microM)>biochanin A (DC(50): 100 microM). In sturgeon, estradiol (DC(50): 5 nM)>genistein (DC(50): 220)>formononetin (DC(50): 1 microM)>equol>(DC(50): 8.3 microM)>daidzein>(DC(50): 80 microM)>biochanin A (DC(50): 100 microM). These results demonstrate that phytoestrogens, mimicking estradiol, can disturb the endocrine system by competing for ER. Also, the higher sensitivity to genistein observed in vivo in Siberian sturgeon (vitellogenin synthesis), compared to rainbow trout, is not due to a higher affinity of genistein for the hepatic ER. Thus, the metabolism of phytoestrogen could be species dependent and affect sensitivity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Latonnelle</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Laboratoire de Génomique et Physiologie des Poissons, Université Bordeaux I, 33405, Talence Cedex, France. k-gontier@enitab.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fostier</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Le Menn</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bennetau-Pelissero</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gen Comp Endocrinol</MedlineTA><NlmUniqueID>0370735</NlmUniqueID><ISSNLinking>0016-6480</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004968">Estrogens, Non-Steroidal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007529">Isoflavones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048789">Phytoestrogens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028321">Plant Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018160">Receptors, Cytoplasmic and Nuclear</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011960">Receptors, Estrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014819">Vitellogenins</NameOfSubstance></Chemical><Chemical><RegistryNumber>295DQC67BJ</RegistryNumber><NameOfSubstance UI="C007768">formononetin</NameOfSubstance></Chemical><Chemical><RegistryNumber>4TI98Z838E</RegistryNumber><NameOfSubstance UI="D004958">Estradiol</NameOfSubstance></Chemical><Chemical><RegistryNumber>DH2M523P0H</RegistryNumber><NameOfSubstance UI="D019833">Genistein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001667" MajorTopicYN="N">Binding, Competitive</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004958" MajorTopicYN="N">Estradiol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName 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mykiss</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048789" MajorTopicYN="N">Phytoestrogens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D028321" MajorTopicYN="N">Plant Preparations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018160" MajorTopicYN="N">Receptors, Cytoplasmic and Nuclear</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011960" MajorTopicYN="N">Receptors, Estrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014819" MajorTopicYN="N">Vitellogenins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>11</Month><Day>21</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>5</Month><Day>21</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>11</Month><Day>21</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12441116</ArticleId><ArticleId IdType="pii">S0016648002005129</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li><li>Talence</li></settlement><orgName><li>Université Bordeaux I</li><li>Université de Bordeaux</li></orgName></list><tree><noCountry><name sortKey="Bennetau Pelissero, C" sort="Bennetau Pelissero, C" uniqKey="Bennetau Pelissero C" first="C" last="Bennetau-Pelissero">C. Bennetau-Pelissero</name><name sortKey="Fostier, A" sort="Fostier, A" uniqKey="Fostier A" first="A" last="Fostier">A. Fostier</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Latonnelle, K" sort="Latonnelle, K" uniqKey="Latonnelle K" first="K" last="Latonnelle">K. Latonnelle</name></region><name sortKey="Le Menn, F" sort="Le Menn, F" uniqKey="Le Menn F" first="F" last="Le Menn">Françoise Le Menn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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