Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage.
Identifieur interne : 000527 ( PubMed/Checkpoint ); précédent : 000526; suivant : 000528Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage.
Auteurs : A. Kawakoshi [Japon] ; S. Hyodo ; K. Inoue ; Y. Kobayashi ; Y. TakeiSource :
- Journal of molecular endocrinology [ 0952-5041 ] ; 2004.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Aorta (drug effects), Aorta (physiology), Base Sequence, Cloning, Molecular, Dogs, Fishes (genetics), In Vitro Techniques, Male, Molecular Sequence Data, Natriuretic Peptides (genetics), Natriuretic Peptides (metabolism), Natriuretic Peptides (pharmacology), Phylogeny, Protein Precursors (genetics), Sequence Homology, Amino Acid, Tetraodontiformes (genetics), Tilapia (genetics), Vasodilator Agents (pharmacology).
- MESH :
- chemical , genetics : Natriuretic Peptides, Protein Precursors.
- drug effects : Aorta.
- genetics : Fishes, Tetraodontiformes, Tilapia.
- chemical , metabolism : Natriuretic Peptides.
- chemical , pharmacology : Natriuretic Peptides, Vasodilator Agents.
- physiology : Aorta.
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Dogs, In Vitro Techniques, Male, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid.
Abstract
The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish. In order to trace the process of divergence of the NP family in early vertebrate evolution, we attempted to detect NPs in the primitive ray-finned fish, the sturgeon (Acipenser transmontanus). Unexpectedly, we isolated four distinct NP cDNAs from the heart and brain of this chondrostean fish. The single NP from the brain was CNP, as judged from the lack of C-terminal 'tail' sequence extending from the intramolecular ring. Two of the three cardiac NPs were ANP and VNP, as judged by the presence of an amidation signal at its C-terminus (ANP) and a long and conserved C-terminal tail sequence (VNP) respectively. The third cardiac NP was most probably BNP because it possessed all the features characteristic of BNP including: (1) the presence of dibasic amino acids within the intramolecular ring; (2) the presence of AUUUA repeats in the 3'-untranslated region of its mRNA; (3) equivalent expression of its mRNA in the atrium and ventricle and appreciable expression in the brain. Based on the sturgeon BNP sequence, we further isolated BNP cDNA from the heart of tilapia and pufferfish for the first time in teleostean fish. Phylogenetic analysis of the precursors showed that newly identified NPs belong to each group of the four NPs. The current identification of both VNP and BNP in the sturgeon clearly showed that BNP and VNP are coded by distinct genes, and that the NP family consists of at least four members in the ray-finned fish. VNP has not been molecularly identified in mammals but its presence is suggested from physiological studies; heterologous fish VNP exhibited more potent vasorelaxant activity than homologous mammalian ANP in the isolated coronary artery of dogs.
PubMed: 15072558
Affiliations:
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Inoue</name></author><author><name sortKey="Kobayashi, Y" sort="Kobayashi, Y" uniqKey="Kobayashi Y" first="Y" last="Kobayashi">Y. Kobayashi</name></author><author><name sortKey="Takei, Y" sort="Takei, Y" uniqKey="Takei Y" first="Y" last="Takei">Y. 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Kawakoshi</name><affiliation wicri:level="1"><nlm:affiliation>Ocean Research Institute, University of Tokyo, Tokyo 164-8639, Japan. kawakosi@ori.u-tokyo.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Ocean Research Institute, University of Tokyo, Tokyo 164-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Hyodo, S" sort="Hyodo, S" uniqKey="Hyodo S" first="S" last="Hyodo">S. Hyodo</name></author><author><name sortKey="Inoue, K" sort="Inoue, K" uniqKey="Inoue K" first="K" last="Inoue">K. Inoue</name></author><author><name sortKey="Kobayashi, Y" sort="Kobayashi, Y" uniqKey="Kobayashi Y" first="Y" last="Kobayashi">Y. Kobayashi</name></author><author><name sortKey="Takei, Y" sort="Takei, Y" uniqKey="Takei Y" first="Y" last="Takei">Y. Takei</name></author></analytic><series><title level="j">Journal of molecular endocrinology</title><idno type="ISSN">0952-5041</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Aorta (drug effects)</term><term>Aorta (physiology)</term><term>Base Sequence</term><term>Cloning, Molecular</term><term>Dogs</term><term>Fishes (genetics)</term><term>In Vitro Techniques</term><term>Male</term><term>Molecular Sequence Data</term><term>Natriuretic Peptides (genetics)</term><term>Natriuretic Peptides (metabolism)</term><term>Natriuretic Peptides (pharmacology)</term><term>Phylogeny</term><term>Protein Precursors (genetics)</term><term>Sequence Homology, Amino Acid</term><term>Tetraodontiformes (genetics)</term><term>Tilapia (genetics)</term><term>Vasodilator Agents (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Natriuretic Peptides</term><term>Protein Precursors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aorta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fishes</term><term>Tetraodontiformes</term><term>Tilapia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Natriuretic Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Natriuretic Peptides</term><term>Vasodilator Agents</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aorta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Cloning, Molecular</term><term>Dogs</term><term>In Vitro Techniques</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Homology, Amino Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish. In order to trace the process of divergence of the NP family in early vertebrate evolution, we attempted to detect NPs in the primitive ray-finned fish, the sturgeon (Acipenser transmontanus). Unexpectedly, we isolated four distinct NP cDNAs from the heart and brain of this chondrostean fish. The single NP from the brain was CNP, as judged from the lack of C-terminal 'tail' sequence extending from the intramolecular ring. Two of the three cardiac NPs were ANP and VNP, as judged by the presence of an amidation signal at its C-terminus (ANP) and a long and conserved C-terminal tail sequence (VNP) respectively. The third cardiac NP was most probably BNP because it possessed all the features characteristic of BNP including: (1) the presence of dibasic amino acids within the intramolecular ring; (2) the presence of AUUUA repeats in the 3'-untranslated region of its mRNA; (3) equivalent expression of its mRNA in the atrium and ventricle and appreciable expression in the brain. Based on the sturgeon BNP sequence, we further isolated BNP cDNA from the heart of tilapia and pufferfish for the first time in teleostean fish. Phylogenetic analysis of the precursors showed that newly identified NPs belong to each group of the four NPs. The current identification of both VNP and BNP in the sturgeon clearly showed that BNP and VNP are coded by distinct genes, and that the NP family consists of at least four members in the ray-finned fish. VNP has not been molecularly identified in mammals but its presence is suggested from physiological studies; heterologous fish VNP exhibited more potent vasorelaxant activity than homologous mammalian ANP in the isolated coronary artery of dogs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15072558</PMID><DateCreated><Year>2004</Year><Month>04</Month><Day>09</Day></DateCreated><DateCompleted><Year>2005</Year><Month>01</Month><Day>11</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0952-5041</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><Issue>2</Issue><PubDate><Year>2004</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of molecular endocrinology</Title><ISOAbbreviation>J. Mol. Endocrinol.</ISOAbbreviation></Journal><ArticleTitle>Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage.</ArticleTitle><Pagination><MedlinePgn>547-55</MedlinePgn></Pagination><Abstract><AbstractText>The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish. In order to trace the process of divergence of the NP family in early vertebrate evolution, we attempted to detect NPs in the primitive ray-finned fish, the sturgeon (Acipenser transmontanus). Unexpectedly, we isolated four distinct NP cDNAs from the heart and brain of this chondrostean fish. The single NP from the brain was CNP, as judged from the lack of C-terminal 'tail' sequence extending from the intramolecular ring. Two of the three cardiac NPs were ANP and VNP, as judged by the presence of an amidation signal at its C-terminus (ANP) and a long and conserved C-terminal tail sequence (VNP) respectively. The third cardiac NP was most probably BNP because it possessed all the features characteristic of BNP including: (1) the presence of dibasic amino acids within the intramolecular ring; (2) the presence of AUUUA repeats in the 3'-untranslated region of its mRNA; (3) equivalent expression of its mRNA in the atrium and ventricle and appreciable expression in the brain. Based on the sturgeon BNP sequence, we further isolated BNP cDNA from the heart of tilapia and pufferfish for the first time in teleostean fish. Phylogenetic analysis of the precursors showed that newly identified NPs belong to each group of the four NPs. The current identification of both VNP and BNP in the sturgeon clearly showed that BNP and VNP are coded by distinct genes, and that the NP family consists of at least four members in the ray-finned fish. 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PubStatus="pubmed"><Year>2004</Year><Month>4</Month><Day>10</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>1</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>4</Month><Day>10</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15072558</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hyodo, S" sort="Hyodo, S" uniqKey="Hyodo S" first="S" last="Hyodo">S. Hyodo</name><name sortKey="Inoue, K" sort="Inoue, K" uniqKey="Inoue K" first="K" last="Inoue">K. Inoue</name><name sortKey="Kobayashi, Y" sort="Kobayashi, Y" uniqKey="Kobayashi Y" first="Y" last="Kobayashi">Y. Kobayashi</name><name sortKey="Takei, Y" sort="Takei, Y" uniqKey="Takei Y" first="Y" last="Takei">Y. Takei</name></noCountry><country name="Japon"><noRegion><name sortKey="Kawakoshi, A" sort="Kawakoshi, A" uniqKey="Kawakoshi A" first="A" last="Kawakoshi">A. Kawakoshi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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