Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon (Acipenser transmontanus).
Identifieur interne : 000478 ( PubMed/Checkpoint ); précédent : 000477; suivant : 000479Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon (Acipenser transmontanus).
Auteurs : P L Tenbrook [États-Unis] ; S M Kendall ; R S TjeerdemaSource :
- Ecotoxicology and environmental safety [ 0147-6513 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Biotransformation, Fishes (metabolism), Motor Activity (drug effects), Nitrophenols (analysis), Nitrophenols (pharmacokinetics), Nitrophenols (toxicity), Toxicity Tests, Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (pharmacokinetics), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Nitrophenols, Water Pollutants, Chemical.
- drug effects : Motor Activity.
- metabolism : Fishes.
- chemical , pharmacokinetics : Nitrophenols, Water Pollutants, Chemical.
- chemical , toxicity : Nitrophenols, Water Pollutants, Chemical.
- Animals, Biotransformation, Toxicity Tests.
Abstract
White sturgeon (Acipencer transmontanus) were exposed to 7.2 microM (1.0 ppm) 14C-labeled p-nitrophenol (PNP) in brackish water for 24 h and then allowed to depurate in clean brackish water for another 24h. Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate.
DOI: 10.1016/j.ecoenv.2005.04.006
PubMed: 15949845
Affiliations:
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Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15949845</PMID><DateCreated><Year>2006</Year><Month>06</Month><Day>09</Day></DateCreated><DateCompleted><Year>2006</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0147-6513</ISSN><JournalIssue CitedMedium="Print"><Volume>64</Volume><Issue>3</Issue><PubDate><Year>2006</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Ecotoxicology and environmental safety</Title><ISOAbbreviation>Ecotoxicol. Environ. Saf.</ISOAbbreviation></Journal><ArticleTitle>Toxicokinetics and biotransformation of p-nitrophenol in white sturgeon (Acipenser transmontanus).</ArticleTitle><Pagination><MedlinePgn>362-8</MedlinePgn></Pagination><Abstract><AbstractText>White sturgeon (Acipencer transmontanus) were exposed to 7.2 microM (1.0 ppm) 14C-labeled p-nitrophenol (PNP) in brackish water for 24 h and then allowed to depurate in clean brackish water for another 24h. Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>TenBrook</LastName><ForeName>P L</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA. ptenbroo@pacbell.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kendall</LastName><ForeName>S M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Tjeerdema</LastName><ForeName>R S</ForeName><Initials>RS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ecotoxicol Environ Saf</MedlineTA><NlmUniqueID>7805381</NlmUniqueID><ISSNLinking>0147-6513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009596">Nitrophenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>Y92ZL45L4R</RegistryNumber><NameOfSubstance UI="C024836">4-nitrophenol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001711" MajorTopicYN="N">Biotransformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005399" MajorTopicYN="N">Fishes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009596" MajorTopicYN="N">Nitrophenols</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>6</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>11</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>6</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15949845</ArticleId><ArticleId IdType="pii">S0147-6513(05)00096-5</ArticleId><ArticleId IdType="doi">10.1016/j.ecoenv.2005.04.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Kendall, S M" sort="Kendall, S M" uniqKey="Kendall S" first="S M" last="Kendall">S M Kendall</name><name sortKey="Tjeerdema, R S" sort="Tjeerdema, R S" uniqKey="Tjeerdema R" first="R S" last="Tjeerdema">R S Tjeerdema</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Tenbrook, P L" sort="Tenbrook, P L" uniqKey="Tenbrook P" first="P L" last="Tenbrook">P L Tenbrook</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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