Serveur d'exploration sur l'esturgeon

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Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)

Identifieur interne : 000279 ( PascalFrancis/Corpus ); précédent : 000278; suivant : 000280

Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)

Auteurs : XIAOLIN HOU ; JIANZHONG SHEN ; SUXIA ZHANG ; HAIYANG JIANG ; Joel R. Coats

Source :

RBID : Pascal:04-0141459

Descripteurs français

English descriptors

Abstract

A steady-state bioconcentration and elimination of sulfamethazine (SM2) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM2, respectively. SM2 and its main metabolite, N4-acetyl-SM2, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCFm) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t1/2) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM2 will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCFm was relatively higher under the low-concentration exposure.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0021-8561
A02 01      @0 JAFCAU
A03   1    @0 J. agric. food chem. : (Print)
A05       @2 51
A06       @2 26
A08 01  1  ENG  @1 Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
A11 01  1    @1 XIAOLIN HOU
A11 02  1    @1 JIANZHONG SHEN
A11 03  1    @1 SUXIA ZHANG
A11 04  1    @1 HAIYANG JIANG
A11 05  1    @1 COATS (Joel R.)
A14 01      @1 Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University @2 Beijing 100094 @3 CHN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.
A14 02      @1 Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University @2 Ames, Iowa 50011 @3 USA @Z 5 aut.
A20       @1 7725-7729
A21       @1 2003
A23 01      @0 ENG
A43 01      @1 INIST @2 7332 @5 354000118986090360
A44       @0 0000 @1 © 2004 INIST-CNRS. All rights reserved.
A45       @0 24 ref.
A47 01  1    @0 04-0141459
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of agricultural and food chemistry : (Print)
A66 01      @0 USA
C01 01    ENG  @0 A steady-state bioconcentration and elimination of sulfamethazine (SM2) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM2, respectively. SM2 and its main metabolite, N4-acetyl-SM2, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCFm) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t1/2) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM2 will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCFm was relatively higher under the low-concentration exposure.
C02 01  X    @0 002A35B06
C03 01  X  FRE  @0 Accumulation biologique @5 01
C03 01  X  ENG  @0 Biological accumulation @5 01
C03 01  X  SPA  @0 Acumulación biológica @5 01
C03 02  X  FRE  @0 Elimination @5 02
C03 02  X  ENG  @0 Elimination @5 02
C03 02  X  SPA  @0 Eliminación @5 02
C03 03  X  FRE  @0 Métabolite @5 03
C03 03  X  ENG  @0 Metabolite @5 03
C03 03  X  SPA  @0 Metabolito @5 03
C03 04  X  FRE  @0 Produit dégradation @5 04
C03 04  X  ENG  @0 Degradation product @5 04
C03 04  X  SPA  @0 Producto degradación @5 04
C03 05  X  FRE  @0 Esturgeon @5 05
C03 05  X  ENG  @0 Sturgeon @5 05
C03 05  X  SPA  @0 Esturión @5 05
C03 06  X  FRE  @0 Effet concentration @5 06
C03 06  X  ENG  @0 Concentration effect @5 06
C03 06  X  SPA  @0 Efecto concentración @5 06
C03 07  X  FRE  @0 Absorption @5 07
C03 07  X  ENG  @0 Absorption @5 07
C03 07  X  SPA  @0 Absorción @5 07
C03 08  X  FRE  @0 Muscle @5 08
C03 08  X  ENG  @0 Muscle @5 08
C03 08  X  SPA  @0 Músculo @5 08
C03 09  X  FRE  @0 Dégradation biologique @5 09
C03 09  X  ENG  @0 Biodegradation @5 09
C03 09  X  SPA  @0 Degradación biológica @5 09
C03 10  X  FRE  @0 Sulfadimidine @2 NK @2 FR @5 15
C03 10  X  ENG  @0 Sulfadimidine @2 NK @2 FR @5 15
C03 10  X  SPA  @0 Sulfadimidina @2 NK @2 FR @5 15
C03 11  X  FRE  @0 Demi vie @5 33
C03 11  X  ENG  @0 Half life @5 33
C03 11  X  SPA  @0 Media vida @5 33
C03 12  X  FRE  @0 Sécurité alimentaire @5 34
C03 12  X  ENG  @0 Food security @5 34
C03 12  X  SPA  @0 Seguridad alimentaria @5 34
C03 13  X  FRE  @0 Toxicologie @5 35
C03 13  X  ENG  @0 Toxicology @5 35
C03 13  X  SPA  @0 Toxicología @5 35
C03 14  X  FRE  @0 Acipenser schrenkii @2 NS @4 INC @5 72
C07 01  X  FRE  @0 Pisces @2 NS @5 46
C07 01  X  ENG  @0 Pisces @2 NS @5 46
C07 01  X  SPA  @0 Pisces @2 NS @5 46
C07 02  X  FRE  @0 Vertebrata @2 NS
C07 02  X  ENG  @0 Vertebrata @2 NS
C07 02  X  SPA  @0 Vertebrata @2 NS
C07 03  X  FRE  @0 Matériau bioactif @5 50
C07 03  X  ENG  @0 Bioactive material @5 50
C07 03  X  SPA  @0 Material bioactivo @5 50
C07 04  X  FRE  @0 Médicament @5 51
C07 04  X  ENG  @0 Drug @5 51
C07 04  X  SPA  @0 Medicamento @5 51
N21       @1 089
N82       @1 PSI

Format Inist (serveur)

NO : PASCAL 04-0141459 INIST
ET : Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
AU : XIAOLIN HOU; JIANZHONG SHEN; SUXIA ZHANG; HAIYANG JIANG; COATS (Joel R.)
AF : Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University/Beijing 100094/Chine (1 aut., 2 aut., 3 aut., 4 aut.); Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University/Ames, Iowa 50011/Etats-Unis (5 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2003; Vol. 51; No. 26; Pp. 7725-7729; Bibl. 24 ref.
LA : Anglais
EA : A steady-state bioconcentration and elimination of sulfamethazine (SM2) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM2, respectively. SM2 and its main metabolite, N4-acetyl-SM2, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCFm) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t1/2) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM2 will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCFm was relatively higher under the low-concentration exposure.
CC : 002A35B06
FD : Accumulation biologique; Elimination; Métabolite; Produit dégradation; Esturgeon; Effet concentration; Absorption; Muscle; Dégradation biologique; Sulfadimidine; Demi vie; Sécurité alimentaire; Toxicologie; Acipenser schrenkii
FG : Pisces; Vertebrata; Matériau bioactif; Médicament
ED : Biological accumulation; Elimination; Metabolite; Degradation product; Sturgeon; Concentration effect; Absorption; Muscle; Biodegradation; Sulfadimidine; Half life; Food security; Toxicology
EG : Pisces; Vertebrata; Bioactive material; Drug
SD : Acumulación biológica; Eliminación; Metabolito; Producto degradación; Esturión; Efecto concentración; Absorción; Músculo; Degradación biológica; Sulfadimidina; Media vida; Seguridad alimentaria; Toxicología
LO : INIST-7332.354000118986090360
ID : 04-0141459

Links to Exploration step

Pascal:04-0141459

Le document en format XML

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<term>Elimination</term>
<term>Food security</term>
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<div type="abstract" xml:lang="en">A steady-state bioconcentration and elimination of sulfamethazine (SM
<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM
<sub>2</sub>
, respectively. SM
<sub>2</sub>
and its main metabolite, N
<sup>4</sup>
-acetyl-SM
<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF
<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t
<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM
<sub>2</sub>
will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF
<sub>m</sub>
was relatively higher under the low-concentration exposure.</div>
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<s0>A steady-state bioconcentration and elimination of sulfamethazine (SM
<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM
<sub>2</sub>
, respectively. SM
<sub>2</sub>
and its main metabolite, N
<sup>4</sup>
-acetyl-SM
<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF
<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t
<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM
<sub>2</sub>
will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF
<sub>m</sub>
was relatively higher under the low-concentration exposure.</s0>
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<s5>02</s5>
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<s0>Eliminación</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Métabolite</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Metabolite</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Metabolito</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Produit dégradation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Degradation product</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Producto degradación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Esturgeon</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Sturgeon</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Esturión</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Effet concentration</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Concentration effect</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Efecto concentración</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Absorption</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Absorption</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Absorción</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Muscle</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Muscle</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Músculo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Dégradation biologique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Biodegradation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Degradación biológica</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Sulfadimidine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Sulfadimidine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Sulfadimidina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>15</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Demi vie</s0>
<s5>33</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Half life</s0>
<s5>33</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Media vida</s0>
<s5>33</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Sécurité alimentaire</s0>
<s5>34</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Food security</s0>
<s5>34</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Seguridad alimentaria</s0>
<s5>34</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Toxicologie</s0>
<s5>35</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Toxicology</s0>
<s5>35</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Toxicología</s0>
<s5>35</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE">
<s0>Acipenser schrenkii</s0>
<s2>NS</s2>
<s4>INC</s4>
<s5>72</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Matériau bioactif</s0>
<s5>50</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Bioactive material</s0>
<s5>50</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Material bioactivo</s0>
<s5>50</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Médicament</s0>
<s5>51</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Drug</s0>
<s5>51</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Medicamento</s0>
<s5>51</s5>
</fC07>
<fN21>
<s1>089</s1>
</fN21>
<fN82>
<s1>PSI</s1>
</fN82>
</pA>
</standard>
<server>
<NO>PASCAL 04-0141459 INIST</NO>
<ET>Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)</ET>
<AU>XIAOLIN HOU; JIANZHONG SHEN; SUXIA ZHANG; HAIYANG JIANG; COATS (Joel R.)</AU>
<AF>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University/Beijing 100094/Chine (1 aut., 2 aut., 3 aut., 4 aut.); Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University/Ames, Iowa 50011/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2003; Vol. 51; No. 26; Pp. 7725-7729; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>A steady-state bioconcentration and elimination of sulfamethazine (SM
<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM
<sub>2</sub>
, respectively. SM
<sub>2</sub>
and its main metabolite, N
<sup>4</sup>
-acetyl-SM
<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF
<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t
<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM
<sub>2</sub>
will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF
<sub>m</sub>
was relatively higher under the low-concentration exposure.</EA>
<CC>002A35B06</CC>
<FD>Accumulation biologique; Elimination; Métabolite; Produit dégradation; Esturgeon; Effet concentration; Absorption; Muscle; Dégradation biologique; Sulfadimidine; Demi vie; Sécurité alimentaire; Toxicologie; Acipenser schrenkii</FD>
<FG>Pisces; Vertebrata; Matériau bioactif; Médicament</FG>
<ED>Biological accumulation; Elimination; Metabolite; Degradation product; Sturgeon; Concentration effect; Absorption; Muscle; Biodegradation; Sulfadimidine; Half life; Food security; Toxicology</ED>
<EG>Pisces; Vertebrata; Bioactive material; Drug</EG>
<SD>Acumulación biológica; Eliminación; Metabolito; Producto degradación; Esturión; Efecto concentración; Absorción; Músculo; Degradación biológica; Sulfadimidina; Media vida; Seguridad alimentaria; Toxicología</SD>
<LO>INIST-7332.354000118986090360</LO>
<ID>04-0141459</ID>
</server>
</inist>
</record>

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