Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
Identifieur interne : 000279 ( PascalFrancis/Corpus ); précédent : 000278; suivant : 000280Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
Auteurs : XIAOLIN HOU ; JIANZHONG SHEN ; SUXIA ZHANG ; HAIYANG JIANG ; Joel R. CoatsSource :
- Journal of agricultural and food chemistry : (Print) [ 0021-8561 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A steady-state bioconcentration and elimination of sulfamethazine (SM2) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM2, respectively. SM2 and its main metabolite, N4-acetyl-SM2, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCFm) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t1/2) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM2 will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCFm was relatively higher under the low-concentration exposure.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 04-0141459 INIST |
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ET : | Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii) |
AU : | XIAOLIN HOU; JIANZHONG SHEN; SUXIA ZHANG; HAIYANG JIANG; COATS (Joel R.) |
AF : | Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University/Beijing 100094/Chine (1 aut., 2 aut., 3 aut., 4 aut.); Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University/Ames, Iowa 50011/Etats-Unis (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2003; Vol. 51; No. 26; Pp. 7725-7729; Bibl. 24 ref. |
LA : | Anglais |
EA : | A steady-state bioconcentration and elimination of sulfamethazine (SM2) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM2, respectively. SM2 and its main metabolite, N4-acetyl-SM2, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCFm) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t1/2) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM2 will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCFm was relatively higher under the low-concentration exposure. |
CC : | 002A35B06 |
FD : | Accumulation biologique; Elimination; Métabolite; Produit dégradation; Esturgeon; Effet concentration; Absorption; Muscle; Dégradation biologique; Sulfadimidine; Demi vie; Sécurité alimentaire; Toxicologie; Acipenser schrenkii |
FG : | Pisces; Vertebrata; Matériau bioactif; Médicament |
ED : | Biological accumulation; Elimination; Metabolite; Degradation product; Sturgeon; Concentration effect; Absorption; Muscle; Biodegradation; Sulfadimidine; Half life; Food security; Toxicology |
EG : | Pisces; Vertebrata; Bioactive material; Drug |
SD : | Acumulación biológica; Eliminación; Metabolito; Producto degradación; Esturión; Efecto concentración; Absorción; Músculo; Degradación biológica; Sulfadimidina; Media vida; Seguridad alimentaria; Toxicología |
LO : | INIST-7332.354000118986090360 |
ID : | 04-0141459 |
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Pascal:04-0141459Le document en format XML
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<term>Concentration effect</term>
<term>Degradation product</term>
<term>Elimination</term>
<term>Food security</term>
<term>Half life</term>
<term>Metabolite</term>
<term>Muscle</term>
<term>Sturgeon</term>
<term>Sulfadimidine</term>
<term>Toxicology</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Accumulation biologique</term>
<term>Elimination</term>
<term>Métabolite</term>
<term>Produit dégradation</term>
<term>Esturgeon</term>
<term>Effet concentration</term>
<term>Absorption</term>
<term>Muscle</term>
<term>Dégradation biologique</term>
<term>Sulfadimidine</term>
<term>Demi vie</term>
<term>Sécurité alimentaire</term>
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<front><div type="abstract" xml:lang="en">A steady-state bioconcentration and elimination of sulfamethazine (SM<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM<sub>2</sub>
, respectively. SM<sub>2</sub>
and its main metabolite, N<sup>4</sup>
-acetyl-SM<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM<sub>2</sub>
will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF<sub>m</sub>
was relatively higher under the low-concentration exposure.</div>
</front>
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<fA11 i1="03" i2="1"><s1>SUXIA ZHANG</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<fA14 i1="02"><s1>Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University</s1>
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<fC01 i1="01" l="ENG"><s0>A steady-state bioconcentration and elimination of sulfamethazine (SM<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM<sub>2</sub>
, respectively. SM<sub>2</sub>
and its main metabolite, N<sup>4</sup>
-acetyl-SM<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM<sub>2</sub>
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</fC01>
<fC02 i1="01" i2="X"><s0>002A35B06</s0>
</fC02>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Biological accumulation</s0>
<s5>01</s5>
</fC03>
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<s5>01</s5>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Elimination</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Eliminación</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Métabolite</s0>
<s5>03</s5>
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<s5>03</s5>
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<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Produit dégradation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Degradation product</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Producto degradación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Esturgeon</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Sturgeon</s0>
<s5>05</s5>
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<s5>06</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s2>FR</s2>
<s5>15</s5>
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<fC03 i1="10" i2="X" l="ENG"><s0>Sulfadimidine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>15</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Sulfadimidina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>15</s5>
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<fC03 i1="11" i2="X" l="FRE"><s0>Demi vie</s0>
<s5>33</s5>
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<s5>33</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Media vida</s0>
<s5>33</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Sécurité alimentaire</s0>
<s5>34</s5>
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<s5>34</s5>
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<s5>34</s5>
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<s5>35</s5>
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<s5>35</s5>
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<s5>35</s5>
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<fC03 i1="14" i2="X" l="FRE"><s0>Acipenser schrenkii</s0>
<s2>NS</s2>
<s4>INC</s4>
<s5>72</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
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<fC07 i1="01" i2="X" l="SPA"><s0>Pisces</s0>
<s2>NS</s2>
<s5>46</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Vertebrata</s0>
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<s5>50</s5>
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<s5>50</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Material bioactivo</s0>
<s5>50</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Médicament</s0>
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<server><NO>PASCAL 04-0141459 INIST</NO>
<ET>Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)</ET>
<AU>XIAOLIN HOU; JIANZHONG SHEN; SUXIA ZHANG; HAIYANG JIANG; COATS (Joel R.)</AU>
<AF>Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agriculture University/Beijing 100094/Chine (1 aut., 2 aut., 3 aut., 4 aut.); Pesticide Toxicology Laboratory, Department of Entomology, Iowa State University/Ames, Iowa 50011/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of agricultural and food chemistry : (Print); ISSN 0021-8561; Coden JAFCAU; Etats-Unis; Da. 2003; Vol. 51; No. 26; Pp. 7725-7729; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>A steady-state bioconcentration and elimination of sulfamethazine (SM<sub>2</sub>
) in the sturgeon (A. schrenkii) was conducted in flow-through aqueous conditions. Two treated groups of fish were exposed to concentrations of 1.00 and 0.10 mg/L of SM<sub>2</sub>
, respectively. SM<sub>2</sub>
and its main metabolite, N<sup>4</sup>
-acetyl-SM<sub>2</sub>
, were determined in both fish muscle and water during the 8-day uptake period and the subsequent 6-day elimination period. Rapid uptakes of the drug were observed in both treated groups. Muscle tissue residues plateaued after ∼3 days. The bioconcentration factor in muscle (BCF<sub>m</sub>
) in the low-concentration drug solution was 1.19 and that in the high-concentration-treated level was 0.61. The calculated biodegradation index was 3.72%. The elimination half-times (t<sub>1/2</sub>
) of the two treatment levels were 19.44 and 23.52 h, respectively. The result indicates that SM<sub>2</sub>
will neither bioconcentrate in individual aquatic organisms nor biomagnify in the food chain, although the BCF<sub>m</sub>
was relatively higher under the low-concentration exposure.</EA>
<CC>002A35B06</CC>
<FD>Accumulation biologique; Elimination; Métabolite; Produit dégradation; Esturgeon; Effet concentration; Absorption; Muscle; Dégradation biologique; Sulfadimidine; Demi vie; Sécurité alimentaire; Toxicologie; Acipenser schrenkii</FD>
<FG>Pisces; Vertebrata; Matériau bioactif; Médicament</FG>
<ED>Biological accumulation; Elimination; Metabolite; Degradation product; Sturgeon; Concentration effect; Absorption; Muscle; Biodegradation; Sulfadimidine; Half life; Food security; Toxicology</ED>
<EG>Pisces; Vertebrata; Bioactive material; Drug</EG>
<SD>Acumulación biológica; Eliminación; Metabolito; Producto degradación; Esturión; Efecto concentración; Absorción; Músculo; Degradación biológica; Sulfadimidina; Media vida; Seguridad alimentaria; Toxicología</SD>
<LO>INIST-7332.354000118986090360</LO>
<ID>04-0141459</ID>
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