Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon
Identifieur interne : 000058 ( PascalFrancis/Corpus ); précédent : 000057; suivant : 000059Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon
Auteurs : Susie Shih-Yin Huang ; Anders Bjerring Strathe ; James G. Fadel ; PINPIN LIN ; Tsung-Yun Liu ; Silas S. O. HungSource :
- Aquatic toxicology [ 0166-445X ] ; 2012.
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- Pascal (Inist)
English descriptors
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Abstract
Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and bio-magnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48 h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48 h post intubation period, and at 48 h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p < 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12 h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48 h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12 h post intubation.
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Format Inist (serveur)
| NO : | PASCAL 12-0361705 INIST |
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| ET : | Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon |
| AU : | SHIH-YIN HUANG (Susie); BJERRING STRATHE (Anders); FADEL (James G.); PINPIN LIN; LIU (Tsung-Yun); HUNG (Silas S. O.) |
| AF : | Department of Animal Science, University of California/Davis, CA 95616/Etats-Unis (1 aut., 2 aut., 3 aut., 6 aut.); Division of Environmental Health and Occupational Medicine, National Health Research Institutes/Zhunan, 350/Taïwan (4 aut.); Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University/Taipei, 112/Taïwan (5 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Aquatic toxicology; ISSN 0166-445X; Coden AQTODG; Pays-Bas; Da. 2012; Vol. 122-23; Pp. 163-171; Bibl. 1 p.1/4 |
| LA : | Anglais |
| EA : | Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and bio-magnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48 h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48 h post intubation period, and at 48 h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p < 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12 h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48 h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12 h post intubation. |
| CC : | 002A14D05A; 002A15B |
| FD : | Absorption; Elimination; Mercure; Temps exposition; Contaminant; Milieu aquatique; Ecotoxicologie; Toxicité; Polluant; Acipenser transmontanus; Mercure(méthyl) |
| FG : | Composé organique; Métal lourd; Pisces; Vertebrata; Acipenseridae |
| ED : | Absorption; Elimination; Mercury; Exposure time; Contaminant; Aquatic environment; Ecotoxicology; Toxicity; Pollutant; Acipenser transmontanus |
| EG : | Organic compounds; Heavy metal; Pisces; Vertebrata |
| SD : | Absorción; Eliminación; Mercurio; Tiempo exposición; Contaminante; Medio acuático; Ecotoxicología; Toxicidad; Contaminante; Acipenser transmontanus |
| LO : | INIST-18841.354000508126360190 |
| ID : | 12-0361705 |
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Fadel</name><affiliation><inist:fA14 i1="01"><s1>Department of Animal Science, University of California</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pinpin Lin" sort="Pinpin Lin" uniqKey="Pinpin Lin" last="Pinpin Lin">PINPIN LIN</name><affiliation><inist:fA14 i1="02"><s1>Division of Environmental Health and Occupational Medicine, National Health Research Institutes</s1><s2>Zhunan, 350</s2><s3>TWN</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Liu, Tsung Yun" sort="Liu, Tsung Yun" uniqKey="Liu T" first="Tsung-Yun" last="Liu">Tsung-Yun Liu</name><affiliation><inist:fA14 i1="03"><s1>Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University</s1><s2>Taipei, 112</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hung, Silas S O" sort="Hung, Silas S O" uniqKey="Hung S" first="Silas S. 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Fadel</name><affiliation><inist:fA14 i1="01"><s1>Department of Animal Science, University of California</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pinpin Lin" sort="Pinpin Lin" uniqKey="Pinpin Lin" last="Pinpin Lin">PINPIN LIN</name><affiliation><inist:fA14 i1="02"><s1>Division of Environmental Health and Occupational Medicine, National Health Research Institutes</s1><s2>Zhunan, 350</s2><s3>TWN</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Liu, Tsung Yun" sort="Liu, Tsung Yun" uniqKey="Liu T" first="Tsung-Yun" last="Liu">Tsung-Yun Liu</name><affiliation><inist:fA14 i1="03"><s1>Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University</s1><s2>Taipei, 112</s2><s3>TWN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hung, Silas S O" sort="Hung, Silas S O" uniqKey="Hung S" first="Silas S. O." last="Hung">Silas S. O. Hung</name><affiliation><inist:fA14 i1="01"><s1>Department of Animal Science, University of California</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorption</term><term>Acipenser transmontanus</term><term>Aquatic environment</term><term>Contaminant</term><term>Ecotoxicology</term><term>Elimination</term><term>Exposure time</term><term>Mercury</term><term>Pollutant</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Absorption</term><term>Elimination</term><term>Mercure</term><term>Temps exposition</term><term>Contaminant</term><term>Milieu aquatique</term><term>Ecotoxicologie</term><term>Toxicité</term><term>Polluant</term><term>Acipenser transmontanus</term><term>Mercure(méthyl)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and bio-magnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48 h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48 h post intubation period, and at 48 h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p < 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12 h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48 h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12 h post intubation.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0166-445X</s0></fA01><fA02 i1="01"><s0>AQTODG</s0></fA02><fA03 i2="1"><s0>Aquat. toxicol.</s0></fA03><fA05><s2>122-23</s2></fA05><fA08 i1="01" i2="1" l="ENG"><s1>Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon</s1></fA08><fA11 i1="01" i2="1"><s1>SHIH-YIN HUANG (Susie)</s1></fA11><fA11 i1="02" i2="1"><s1>BJERRING STRATHE (Anders)</s1></fA11><fA11 i1="03" i2="1"><s1>FADEL (James G.)</s1></fA11><fA11 i1="04" i2="1"><s1>PINPIN LIN</s1></fA11><fA11 i1="05" i2="1"><s1>LIU (Tsung-Yun)</s1></fA11><fA11 i1="06" i2="1"><s1>HUNG (Silas S. O.)</s1></fA11><fA14 i1="01"><s1>Department of Animal Science, University of California</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Environmental Health and Occupational Medicine, National Health Research Institutes</s1><s2>Zhunan, 350</s2><s3>TWN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University</s1><s2>Taipei, 112</s2><s3>TWN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>163-171</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18841</s2><s5>354000508126360190</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>12-0361705</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Aquatic toxicology</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and bio-magnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48 h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48 h post intubation period, and at 48 h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p < 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12 h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48 h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12 h post intubation.</s0></fC01><fC02 i1="01" i2="X"><s0>002A14D05A</s0></fC02><fC02 i1="02" i2="X"><s0>002A15B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Absorption</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Absorption</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Absorción</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Elimination</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Elimination</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Eliminación</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Mercure</s0><s2>NC</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Mercury</s0><s2>NC</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Mercurio</s0><s2>NC</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Temps exposition</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Exposure time</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tiempo exposición</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Contaminant</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Contaminant</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Contaminante</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Milieu aquatique</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Aquatic environment</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Medio acuático</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Ecotoxicologie</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Ecotoxicology</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Ecotoxicología</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Toxicité</s0><s5>23</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Toxicity</s0><s5>23</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Toxicidad</s0><s5>23</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Polluant</s0><s5>24</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Pollutant</s0><s5>24</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Contaminante</s0><s5>24</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Acipenser transmontanus</s0><s2>NS</s2><s5>49</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Acipenser transmontanus</s0><s2>NS</s2><s5>49</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Acipenser transmontanus</s0><s2>NS</s2><s5>49</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Mercure(méthyl)</s0><s4>INC</s4><s5>87</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Composé organique</s0><s2>NA</s2><s5>17</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Organic compounds</s0><s2>NA</s2><s5>17</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Compuesto orgánico</s0><s2>NA</s2><s5>17</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Métal lourd</s0><s5>18</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Heavy metal</s0><s5>18</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Metal pesado</s0><s5>18</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pisces</s0><s2>NS</s2><s5>29</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Pisces</s0><s2>NS</s2><s5>29</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Pisces</s0><s2>NS</s2><s5>29</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Acipenseridae</s0><s4>INC</s4><s5>70</s5></fC07><fN21><s1>282</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0361705 INIST</NO><ET>Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon</ET><AU>SHIH-YIN HUANG (Susie); BJERRING STRATHE (Anders); FADEL (James G.); PINPIN LIN; LIU (Tsung-Yun); HUNG (Silas S. O.)</AU><AF>Department of Animal Science, University of California/Davis, CA 95616/Etats-Unis (1 aut., 2 aut., 3 aut., 6 aut.); Division of Environmental Health and Occupational Medicine, National Health Research Institutes/Zhunan, 350/Taïwan (4 aut.); Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang-Ming University/Taipei, 112/Taïwan (5 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Aquatic toxicology; ISSN 0166-445X; Coden AQTODG; Pays-Bas; Da. 2012; Vol. 122-23; Pp. 163-171; Bibl. 1 p.1/4</SO><LA>Anglais</LA><EA>Mercury (Hg) is toxic and is released into the environment from a wide variety of anthropogenic sources. Methylmercury (MeHg), a product of microbial methylation, enables rapid Hg bioaccumulation and bio-magnification in the biota. Methylmercury is sequestered and made available to the rest of the biota through the benthic-detrital component leading to the high risk of exposure to benthic fish species, such as white sturgeon (Acipenser transmontanus). In the present study, a combined technique of stomach intubation, dorsal aorta cannulation, and urinary catheterization was utilized to characterize the absorption, distribution, and elimination of Hg in white sturgeon over a 48 h exposure. Mercury, as methylmercury chloride, at either 0, 250, 500, or 1000 μg Hg/kg body weight, was orally intubated into white sturgeon, in groups of five. The blood was repeatedly sampled and urine collected from the fish over the 48 h post intubation period, and at 48 h, the fish were sacrificed for Hg tissue concentration and distribution determinations. The fractional rate of absorption (K), blood Hg concentration (μg/ml), tissue concentration (μg/g dry weight) and distribution (%), and urinary Hg elimination flux (μg/kg/h) are significantly different (p < 0.05) among the MeHg doses. Complete blood uptake of Hg was observed in all MeHg treated fish by 12 h. The maximal observed blood Hg concentration peaks are 0.56 ± 0.02, 0.70 ± 0.02, and 2.19 ± 0.07 μg/ml (mean ± SEM) for the 250, 500, and 1000 μg Hg/kg body weight dose groups, respectively. Changes in blood Hg profiles can be described by a monomolecular function in all of the MeHg treated fish. The Hg concentration asymptote (A) and K are dose dependent. The relationship between A and the intubation dose, however, is nonlinear. Mercury levels in certain tissues are comparable to field data and longer-term study, indicating that the lower doses used in the current study are ecologically relevant for the species. Tissue Hg concentrations are in the following decreasing order: gastro-intestinal tract > kidney > spleen > gill > heart > liver > brain > white muscle and remaining whole body. At 48 h, Hg was found to be preferentially distributed to metabolically active tissues. Digestibility is highest at the lowest MeHg dose. Measurable urinary Hg was observed in the fish treated with the highest MeHg dose, and a significant increase in the elimination flux was observed between 3 and 12 h post intubation.</EA><CC>002A14D05A; 002A15B</CC><FD>Absorption; Elimination; Mercure; Temps exposition; Contaminant; Milieu aquatique; Ecotoxicologie; Toxicité; Polluant; Acipenser transmontanus; Mercure(méthyl)</FD><FG>Composé organique; Métal lourd; Pisces; Vertebrata; Acipenseridae</FG><ED>Absorption; Elimination; Mercury; Exposure time; Contaminant; Aquatic environment; Ecotoxicology; Toxicity; Pollutant; Acipenser transmontanus</ED><EG>Organic compounds; Heavy metal; Pisces; Vertebrata</EG><SD>Absorción; Eliminación; Mercurio; Tiempo exposición; Contaminante; Medio acuático; Ecotoxicología; Toxicidad; Contaminante; Acipenser transmontanus</SD><LO>INIST-18841.354000508126360190</LO><ID>12-0361705</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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