Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats.
Identifieur interne : 000659 ( Ncbi/Merge ); précédent : 000658; suivant : 000660Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats.
Auteurs : Nihal Cetin [Turquie] ; Bahtiyar Suleyman ; Ufuk Kuyrukluyildiz ; Hatice Sevim Nalkiran ; Altan Kiran ; Songul Gencoglu ; Ahmet Duzgun ; Ilker Zeki Kurtoglu ; Oguzhan Yarali ; Mehmet Ali Gul ; Halis SuleymanSource :
- Experimental animals [ 1881-7122 ] ; 2016.
English descriptors
- KwdEn :
- Acute Pain (genetics), Acute Pain (metabolism), Acute Pain (therapy), Analgesics, Animals, Antioxidants (metabolism), Cyclooxygenase 2 (genetics), Cyclooxygenase 2 (metabolism), Diclofenac (therapeutic use), Fishes, Gene Expression, Male, Mucus, Oxidants (metabolism), Pain, Postoperative (therapy), Rats, Wistar.
- MESH :
- chemical , genetics : Cyclooxygenase 2.
- chemical , metabolism : Antioxidants, Cyclooxygenase 2, Oxidants.
- chemical , therapeutic use : Diclofenac.
- chemical : Analgesics.
- genetics : Acute Pain.
- metabolism : Acute Pain.
- therapy : Acute Pain, Pain, Postoperative.
- Animals, Fishes, Gene Expression, Male, Mucus, Rats, Wistar.
Abstract
No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain.
DOI: 10.1538/expanim.15-0051
PubMed: 26490740
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats.</title><author><name sortKey="Cetin, Nihal" sort="Cetin, Nihal" uniqKey="Cetin N" first="Nihal" last="Cetin">Nihal Cetin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030, Erzincan, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030, Erzincan</wicri:regionArea><wicri:noRegion>Erzincan</wicri:noRegion></affiliation></author><author><name sortKey="Suleyman, Bahtiyar" sort="Suleyman, Bahtiyar" uniqKey="Suleyman B" first="Bahtiyar" last="Suleyman">Bahtiyar Suleyman</name></author><author><name sortKey="Kuyrukluyildiz, Ufuk" sort="Kuyrukluyildiz, Ufuk" uniqKey="Kuyrukluyildiz U" first="Ufuk" last="Kuyrukluyildiz">Ufuk Kuyrukluyildiz</name></author><author><name sortKey="Nalkiran, Hatice Sevim" sort="Nalkiran, Hatice Sevim" uniqKey="Nalkiran H" first="Hatice Sevim" last="Nalkiran">Hatice Sevim Nalkiran</name></author><author><name sortKey="Kiran, Altan" sort="Kiran, Altan" uniqKey="Kiran A" first="Altan" last="Kiran">Altan Kiran</name></author><author><name sortKey="Gencoglu, Songul" sort="Gencoglu, Songul" uniqKey="Gencoglu S" first="Songul" last="Gencoglu">Songul Gencoglu</name></author><author><name sortKey="Duzgun, Ahmet" sort="Duzgun, Ahmet" uniqKey="Duzgun A" first="Ahmet" last="Duzgun">Ahmet Duzgun</name></author><author><name sortKey="Kurtoglu, Ilker Zeki" sort="Kurtoglu, Ilker Zeki" uniqKey="Kurtoglu I" first="Ilker Zeki" last="Kurtoglu">Ilker Zeki Kurtoglu</name></author><author><name sortKey="Yarali, Oguzhan" sort="Yarali, Oguzhan" uniqKey="Yarali O" first="Oguzhan" last="Yarali">Oguzhan Yarali</name></author><author><name sortKey="Gul, Mehmet Ali" sort="Gul, Mehmet Ali" uniqKey="Gul M" 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mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats.</title><author><name sortKey="Cetin, Nihal" sort="Cetin, Nihal" uniqKey="Cetin N" first="Nihal" last="Cetin">Nihal Cetin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030, Erzincan, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030, Erzincan</wicri:regionArea><wicri:noRegion>Erzincan</wicri:noRegion></affiliation></author><author><name sortKey="Suleyman, Bahtiyar" sort="Suleyman, Bahtiyar" uniqKey="Suleyman B" first="Bahtiyar" last="Suleyman">Bahtiyar Suleyman</name></author><author><name sortKey="Kuyrukluyildiz, Ufuk" sort="Kuyrukluyildiz, Ufuk" uniqKey="Kuyrukluyildiz U" first="Ufuk" last="Kuyrukluyildiz">Ufuk Kuyrukluyildiz</name></author><author><name sortKey="Nalkiran, Hatice Sevim" sort="Nalkiran, Hatice Sevim" uniqKey="Nalkiran H" first="Hatice Sevim" last="Nalkiran">Hatice Sevim Nalkiran</name></author><author><name sortKey="Kiran, Altan" sort="Kiran, Altan" uniqKey="Kiran A" first="Altan" last="Kiran">Altan Kiran</name></author><author><name sortKey="Gencoglu, Songul" sort="Gencoglu, Songul" uniqKey="Gencoglu S" first="Songul" last="Gencoglu">Songul Gencoglu</name></author><author><name sortKey="Duzgun, Ahmet" sort="Duzgun, Ahmet" uniqKey="Duzgun A" first="Ahmet" last="Duzgun">Ahmet Duzgun</name></author><author><name sortKey="Kurtoglu, Ilker Zeki" sort="Kurtoglu, Ilker Zeki" uniqKey="Kurtoglu I" first="Ilker Zeki" last="Kurtoglu">Ilker Zeki Kurtoglu</name></author><author><name sortKey="Yarali, Oguzhan" sort="Yarali, Oguzhan" uniqKey="Yarali O" first="Oguzhan" last="Yarali">Oguzhan Yarali</name></author><author><name sortKey="Gul, Mehmet Ali" sort="Gul, Mehmet Ali" uniqKey="Gul M" first="Mehmet Ali" last="Gul">Mehmet Ali Gul</name></author><author><name sortKey="Suleyman, Halis" sort="Suleyman, Halis" uniqKey="Suleyman H" first="Halis" last="Suleyman">Halis Suleyman</name></author></analytic><series><title level="j">Experimental animals</title><idno type="eISSN">1881-7122</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Pain (genetics)</term><term>Acute Pain (metabolism)</term><term>Acute Pain (therapy)</term><term>Analgesics</term><term>Animals</term><term>Antioxidants (metabolism)</term><term>Cyclooxygenase 2 (genetics)</term><term>Cyclooxygenase 2 (metabolism)</term><term>Diclofenac (therapeutic use)</term><term>Fishes</term><term>Gene Expression</term><term>Male</term><term>Mucus</term><term>Oxidants (metabolism)</term><term>Pain, Postoperative (therapy)</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclooxygenase 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Cyclooxygenase 2</term><term>Oxidants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diclofenac</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Analgesics</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Acute Pain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Pain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Acute Pain</term><term>Pain, Postoperative</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fishes</term><term>Gene Expression</term><term>Male</term><term>Mucus</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26490740</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1881-7122</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>1</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Experimental animals</Title><ISOAbbreviation>Exp. Anim.</ISOAbbreviation></Journal><ArticleTitle>Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats.</ArticleTitle><Pagination><MedlinePgn>77-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1538/expanim.15-0051</ELocationID><Abstract><AbstractText>No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cetin</LastName><ForeName>Nihal</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030, Erzincan, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suleyman</LastName><ForeName>Bahtiyar</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Kuyrukluyildiz</LastName><ForeName>Ufuk</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Nalkiran</LastName><ForeName>Hatice Sevim</ForeName><Initials>HS</Initials></Author><Author ValidYN="Y"><LastName>Kiran</LastName><ForeName>Altan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gencoglu</LastName><ForeName>Songul</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Duzgun</LastName><ForeName>Ahmet</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kurtoglu</LastName><ForeName>Ilker Zeki</ForeName><Initials>IZ</Initials></Author><Author ValidYN="Y"><LastName>Yarali</LastName><ForeName>Oguzhan</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Gul</LastName><ForeName>Mehmet Ali</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Suleyman</LastName><ForeName>Halis</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Exp Anim</MedlineTA><NlmUniqueID>9604830</NlmUniqueID><ISSNLinking>0007-5124</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000700">Analgesics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016877">Oxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>144O8QL0L1</RegistryNumber><NameOfSubstance UI="D004008">Diclofenac</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Life Sci. 2000;67(10):1127-37</RefSource><PMID Version="1">10954047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Physiol Pharmacol. 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MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004008" MajorTopicYN="N">Diclofenac</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005399" MajorTopicYN="Y">Fishes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009093" MajorTopicYN="Y">Mucus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016877" MajorTopicYN="N">Oxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010149" MajorTopicYN="N">Pain, Postoperative</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4783653</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26490740</ArticleId><ArticleId IdType="doi">10.1538/expanim.15-0051</ArticleId><ArticleId IdType="pmc">PMC4783653</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Duzgun, Ahmet" sort="Duzgun, Ahmet" uniqKey="Duzgun A" first="Ahmet" last="Duzgun">Ahmet Duzgun</name><name sortKey="Gencoglu, Songul" sort="Gencoglu, Songul" uniqKey="Gencoglu S" first="Songul" last="Gencoglu">Songul Gencoglu</name><name sortKey="Gul, Mehmet Ali" sort="Gul, Mehmet Ali" uniqKey="Gul M" first="Mehmet Ali" last="Gul">Mehmet Ali Gul</name><name sortKey="Kiran, Altan" sort="Kiran, Altan" uniqKey="Kiran A" first="Altan" last="Kiran">Altan Kiran</name><name sortKey="Kurtoglu, Ilker Zeki" sort="Kurtoglu, Ilker Zeki" uniqKey="Kurtoglu I" first="Ilker Zeki" last="Kurtoglu">Ilker Zeki Kurtoglu</name><name sortKey="Kuyrukluyildiz, Ufuk" sort="Kuyrukluyildiz, Ufuk" uniqKey="Kuyrukluyildiz U" first="Ufuk" last="Kuyrukluyildiz">Ufuk Kuyrukluyildiz</name><name sortKey="Nalkiran, Hatice Sevim" sort="Nalkiran, Hatice Sevim" uniqKey="Nalkiran H" first="Hatice Sevim" last="Nalkiran">Hatice Sevim Nalkiran</name><name sortKey="Suleyman, Bahtiyar" sort="Suleyman, Bahtiyar" uniqKey="Suleyman B" first="Bahtiyar" last="Suleyman">Bahtiyar Suleyman</name><name sortKey="Suleyman, Halis" sort="Suleyman, Halis" uniqKey="Suleyman H" first="Halis" last="Suleyman">Halis Suleyman</name><name sortKey="Yarali, Oguzhan" sort="Yarali, Oguzhan" uniqKey="Yarali O" first="Oguzhan" last="Yarali">Oguzhan Yarali</name></noCountry><country name="Turquie"><noRegion><name sortKey="Cetin, Nihal" sort="Cetin, Nihal" uniqKey="Cetin N" first="Nihal" last="Cetin">Nihal Cetin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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