Regulation of calcium balance in the sturgeon Acipenser naccarii: a role for PTHrP.
Identifieur interne : 000222 ( Ncbi/Merge ); précédent : 000221; suivant : 000223Regulation of calcium balance in the sturgeon Acipenser naccarii: a role for PTHrP.
Auteurs : Juan Fuentes [Portugal] ; Christophe Haond ; Pedro M. Guerreiro ; Nádia Silva ; Deborah M. Power ; Adelino V M. CanárioSource :
- American journal of physiology. Regulatory, integrative and comparative physiology [ 0363-6119 ] ; 2007.
English descriptors
- KwdEn :
- Animal Feed, Animals, Calcium Radioisotopes, Calcium, Dietary (blood), Calcium, Dietary (pharmacokinetics), Cartilage (metabolism), Endocrine System (metabolism), Fishes (metabolism), Gills (cytology), Gills (enzymology), Homeostasis (drug effects), Homeostasis (physiology), Parathyroid Hormone-Related Protein (metabolism), Parathyroid Hormone-Related Protein (pharmacology), Peptide Fragments (metabolism), Peptide Fragments (pharmacology), Sodium-Potassium-Exchanging ATPase (metabolism).
- MESH :
- chemical , blood : Calcium, Dietary.
- chemical , metabolism : Parathyroid Hormone-Related Protein, Peptide Fragments, Sodium-Potassium-Exchanging ATPase.
- chemical , pharmacokinetics : Calcium, Dietary.
- chemical , pharmacology : Parathyroid Hormone-Related Protein, Peptide Fragments.
- chemical : Calcium Radioisotopes.
- cytology : Gills.
- drug effects : Homeostasis.
- enzymology : Gills.
- metabolism : Cartilage, Endocrine System, Fishes.
- physiology : Homeostasis.
- Animal Feed, Animals.
Abstract
Calcium regulation in sturgeon is of special interest because they are a representative of the ancient fishes possessing mainly cartilaginous skeletons and a supposedly low calcium demand. The present study aimed to characterize the effect of a chronic absence of dietary calcium and the effect of parathyroid hormone-related protein (PTHrPA) (1-34) (7) on calcium balance in juvenile sturgeon (Acipenser naccarii). At rest, sturgeon juveniles are in net positive calcium balance, since whole body calcium uptake is significantly higher than efflux and calcium accumulates in the body. To study the importance of dietary calcium, the sturgeon were kept on a calcium-free diet for 8 wk. This manipulation impaired growth as measured by failure to gain weight or increase in length and indicates that dietary calcium is important for growth in sturgeon. An increased whole body calcium uptake partially compensated dietary calcium deficiency and was associated with increased gill chloride cell number in lamellae and filaments in parallel with increased gill Na(+)K(+)-ATPase activity. In addition, a single injection of piscine PTHrP(1-34) significantly increased whole body calcium uptake and decreased whole body calcium efflux. Administration of PTHrP significantly increased circulating plasma calcium 4-24 h postinjection. The increase in net calcium transport and increased plasma levels of calcium is consistent with the actions of a hypercalcemic factor. It would appear that the sturgeon rely on calcium for growth and tightly regulate calcium transport. The action in calcium balance is consistent with PTHrP acting as a hypercalcemic factor in sturgeon.
DOI: 10.1152/ajpregu.00203.2007
PubMed: 17491110
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Guerreiro</name></author><author><name sortKey="Silva, Nadia" sort="Silva, Nadia" uniqKey="Silva N" first="Nádia" last="Silva">Nádia Silva</name></author><author><name sortKey="Power, Deborah M" sort="Power, Deborah M" uniqKey="Power D" first="Deborah M" last="Power">Deborah M. Power</name></author><author><name sortKey="Canario, Adelino V M" sort="Canario, Adelino V M" uniqKey="Canario A" first="Adelino V M" last="Canário">Adelino V M. Canário</name></author></analytic><series><title level="j">American journal of physiology. Regulatory, integrative and comparative physiology</title><idno type="ISSN">0363-6119</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal Feed</term><term>Animals</term><term>Calcium Radioisotopes</term><term>Calcium, Dietary (blood)</term><term>Calcium, Dietary (pharmacokinetics)</term><term>Cartilage (metabolism)</term><term>Endocrine System (metabolism)</term><term>Fishes (metabolism)</term><term>Gills (cytology)</term><term>Gills (enzymology)</term><term>Homeostasis (drug effects)</term><term>Homeostasis (physiology)</term><term>Parathyroid Hormone-Related Protein (metabolism)</term><term>Parathyroid Hormone-Related Protein (pharmacology)</term><term>Peptide Fragments (metabolism)</term><term>Peptide Fragments (pharmacology)</term><term>Sodium-Potassium-Exchanging ATPase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Calcium, Dietary</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Parathyroid Hormone-Related Protein</term><term>Peptide Fragments</term><term>Sodium-Potassium-Exchanging ATPase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Calcium, Dietary</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Parathyroid Hormone-Related Protein</term><term>Peptide Fragments</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Gills</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Homeostasis</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Gills</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cartilage</term><term>Endocrine System</term><term>Fishes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Homeostasis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animal Feed</term><term>Animals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Calcium regulation in sturgeon is of special interest because they are a representative of the ancient fishes possessing mainly cartilaginous skeletons and a supposedly low calcium demand. The present study aimed to characterize the effect of a chronic absence of dietary calcium and the effect of parathyroid hormone-related protein (PTHrPA) (1-34) (7) on calcium balance in juvenile sturgeon (Acipenser naccarii). At rest, sturgeon juveniles are in net positive calcium balance, since whole body calcium uptake is significantly higher than efflux and calcium accumulates in the body. To study the importance of dietary calcium, the sturgeon were kept on a calcium-free diet for 8 wk. This manipulation impaired growth as measured by failure to gain weight or increase in length and indicates that dietary calcium is important for growth in sturgeon. An increased whole body calcium uptake partially compensated dietary calcium deficiency and was associated with increased gill chloride cell number in lamellae and filaments in parallel with increased gill Na(+)K(+)-ATPase activity. In addition, a single injection of piscine PTHrP(1-34) significantly increased whole body calcium uptake and decreased whole body calcium efflux. Administration of PTHrP significantly increased circulating plasma calcium 4-24 h postinjection. The increase in net calcium transport and increased plasma levels of calcium is consistent with the actions of a hypercalcemic factor. It would appear that the sturgeon rely on calcium for growth and tightly regulate calcium transport. The action in calcium balance is consistent with PTHrP acting as a hypercalcemic factor in sturgeon.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17491110</PMID><DateCreated><Year>2007</Year><Month>08</Month><Day>01</Day></DateCreated><DateCompleted><Year>2007</Year><Month>10</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0363-6119</ISSN><JournalIssue CitedMedium="Print"><Volume>293</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Aug</Month></PubDate></JournalIssue><Title>American journal of physiology. Regulatory, integrative and comparative physiology</Title><ISOAbbreviation>Am. J. Physiol. Regul. Integr. Comp. 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This manipulation impaired growth as measured by failure to gain weight or increase in length and indicates that dietary calcium is important for growth in sturgeon. An increased whole body calcium uptake partially compensated dietary calcium deficiency and was associated with increased gill chloride cell number in lamellae and filaments in parallel with increased gill Na(+)K(+)-ATPase activity. In addition, a single injection of piscine PTHrP(1-34) significantly increased whole body calcium uptake and decreased whole body calcium efflux. Administration of PTHrP significantly increased circulating plasma calcium 4-24 h postinjection. The increase in net calcium transport and increased plasma levels of calcium is consistent with the actions of a hypercalcemic factor. It would appear that the sturgeon rely on calcium for growth and tightly regulate calcium transport. The action in calcium balance is consistent with PTHrP acting as a hypercalcemic factor in sturgeon.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fuentes</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centro de Ciências do Mar, CIMAR-Laboratório Associado, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. jfuentes@ualg.pt</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haond</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Guerreiro</LastName><ForeName>Pedro M</ForeName><Initials>PM</Initials></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>Nádia</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Power</LastName><ForeName>Deborah M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Canário</LastName><ForeName>Adelino V M</ForeName><Initials>AV</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>05</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Physiol Regul Integr Comp Physiol</MedlineTA><NlmUniqueID>100901230</NlmUniqueID><ISSNLinking>0363-6119</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002132">Calcium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002136">Calcium, Dietary</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044162">Parathyroid Hormone-Related 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PubStatus="pubmed"><Year>2007</Year><Month>5</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>10</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>5</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17491110</ArticleId><ArticleId IdType="pii">00203.2007</ArticleId><ArticleId IdType="doi">10.1152/ajpregu.00203.2007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Portugal</li></country></list><tree><noCountry><name sortKey="Canario, Adelino V M" sort="Canario, Adelino V M" uniqKey="Canario A" first="Adelino V M" last="Canário">Adelino V M. Canário</name><name sortKey="Guerreiro, Pedro M" sort="Guerreiro, Pedro M" uniqKey="Guerreiro P" first="Pedro M" last="Guerreiro">Pedro M. Guerreiro</name><name sortKey="Haond, Christophe" sort="Haond, Christophe" uniqKey="Haond C" first="Christophe" last="Haond">Christophe Haond</name><name sortKey="Power, Deborah M" sort="Power, Deborah M" uniqKey="Power D" first="Deborah M" last="Power">Deborah M. Power</name><name sortKey="Silva, Nadia" sort="Silva, Nadia" uniqKey="Silva N" first="Nádia" last="Silva">Nádia Silva</name></noCountry><country name="Portugal"><noRegion><name sortKey="Fuentes, Juan" sort="Fuentes, Juan" uniqKey="Fuentes J" first="Juan" last="Fuentes">Juan Fuentes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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