Phylogenetic analysis of the vertebrate glycoprotein hormone family including new sequences of sturgeon (Acipenser baeri) beta subunits of the two gonadotropins and the thyroid-stimulating hormone.
Identifieur interne : 000020 ( Ncbi/Curation ); précédent : 000019; suivant : 000021Phylogenetic analysis of the vertebrate glycoprotein hormone family including new sequences of sturgeon (Acipenser baeri) beta subunits of the two gonadotropins and the thyroid-stimulating hormone.
Auteurs : B. Quérat [France] ; A. Sellouk ; C. SalmonSource :
- Biology of reproduction [ 0006-3363 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Follicle Stimulating Hormone, Gonadotropins, Pituitary, Luteinizing Hormone, Thyrotropin.
- physiology : Fishes, Vertebrates.
- Amino Acid Sequence, Animals, Female, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid.
Abstract
The beta subunits of the two gonadotropins (GTH1 and GTH2) and of the thyroid-stimulating hormone (TSH) of a chondrostean fish, Acipenser baeri, were cloned. These new sequences and selected representative members of beta subunits of vertebrate glycoprotein hormones, including tetrapod follicle-stimulating hormones (FSH) and luteinizing hormones (LH), allowed us to infer the phylogenetic relationships within this family. Both distance matrix and maximum parsimony methods were used on both nucleotide and amino acid sequences, with bootstrapping evaluation over 1000 replicates. The four trees obtained had highly similar topologies. In each case, three monophylogenetic lineages, TSH, GTH1-FSH, and GTH2-LH were clearly identified. The three monophylogenetic lineages were supported by 21-23 specific characters at the amino acid level, out of a total of 121 characters. The resolved topologies within each monophyletic hormone cluster were congruent with the known phylogenetic relationships between the related species. The inferred parental relationships within gonadotropins are in agreement with data concerning their biological functions. The present study demonstrates that GTH1 and GTH2 are the actinopterygian homologues of tetrapod FSH and LH, respectively.
PubMed: 10859263
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pubmed:10859263Le document en format XML
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Quérat</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Physiologie Générale et Comparée, UMR 8572 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05, France. querat@mnhn.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Physiologie Générale et Comparée, UMR 8572 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sellouk, A" sort="Sellouk, A" uniqKey="Sellouk A" first="A" last="Sellouk">A. Sellouk</name></author><author><name sortKey="Salmon, C" sort="Salmon, C" uniqKey="Salmon C" first="C" last="Salmon">C. 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Quérat</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Physiologie Générale et Comparée, UMR 8572 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05, France. querat@mnhn.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Physiologie Générale et Comparée, UMR 8572 CNRS, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sellouk, A" sort="Sellouk, A" uniqKey="Sellouk A" first="A" last="Sellouk">A. Sellouk</name></author><author><name sortKey="Salmon, C" sort="Salmon, C" uniqKey="Salmon C" first="C" last="Salmon">C. Salmon</name></author></analytic><series><title level="j">Biology of reproduction</title><idno type="ISSN">0006-3363</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Female</term><term>Fishes (physiology)</term><term>Follicle Stimulating Hormone (genetics)</term><term>Gonadotropins, Pituitary (genetics)</term><term>Luteinizing Hormone (genetics)</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Homology, Amino Acid</term><term>Thyrotropin (genetics)</term><term>Vertebrates (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Follicle Stimulating Hormone</term><term>Gonadotropins, Pituitary</term><term>Luteinizing Hormone</term><term>Thyrotropin</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fishes</term><term>Vertebrates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Female</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Homology, Amino Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The beta subunits of the two gonadotropins (GTH1 and GTH2) and of the thyroid-stimulating hormone (TSH) of a chondrostean fish, Acipenser baeri, were cloned. These new sequences and selected representative members of beta subunits of vertebrate glycoprotein hormones, including tetrapod follicle-stimulating hormones (FSH) and luteinizing hormones (LH), allowed us to infer the phylogenetic relationships within this family. Both distance matrix and maximum parsimony methods were used on both nucleotide and amino acid sequences, with bootstrapping evaluation over 1000 replicates. The four trees obtained had highly similar topologies. In each case, three monophylogenetic lineages, TSH, GTH1-FSH, and GTH2-LH were clearly identified. The three monophylogenetic lineages were supported by 21-23 specific characters at the amino acid level, out of a total of 121 characters. The resolved topologies within each monophyletic hormone cluster were congruent with the known phylogenetic relationships between the related species. The inferred parental relationships within gonadotropins are in agreement with data concerning their biological functions. The present study demonstrates that GTH1 and GTH2 are the actinopterygian homologues of tetrapod FSH and LH, respectively.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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