TGF-beta3 exists in bony fish.
Identifieur interne : 000011 ( Ncbi/Curation ); précédent : 000010; suivant : 000012TGF-beta3 exists in bony fish.
Auteurs : K J Laing [Royaume-Uni] ; L. Pilström ; C. Cunningham ; C J SecombesSource :
- Veterinary immunology and immunopathology [ 0165-2427 ] ; 1999.
English descriptors
- KwdEn :
- Amino Acid Sequence, Anguilla (classification), Anguilla (genetics), Animals, Base Sequence, Cloning, Molecular, DNA (chemistry), DNA (isolation & purification), DNA Primers (chemistry), DNA Probes (chemistry), Electrophoresis, Agar Gel (veterinary), Fishes (classification), Fishes (genetics), Molecular Sequence Data, Oncorhynchus mykiss (classification), Oncorhynchus mykiss (genetics), Phylogeny, Polymerase Chain Reaction (veterinary), Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Transforming Growth Factor beta (chemistry), Transforming Growth Factor beta (genetics).
- MESH :
- chemical , chemistry : DNA, DNA Primers, DNA Probes, Transforming Growth Factor beta.
- classification : Anguilla, Fishes, Oncorhynchus mykiss.
- genetics : Anguilla, Fishes, Oncorhynchus mykiss, Transforming Growth Factor beta.
- chemical , isolation & purification : DNA.
- veterinary : Electrophoresis, Agar Gel, Polymerase Chain Reaction.
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Molecular Sequence Data, Phylogeny, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid.
Abstract
A partial nucleotide sequence of transforming growth factor-beta3 (TGF-beta3) has been isolated from the Siberian sturgeon (Acipenser baeri), rainbow trout (Oncorhynchus mykiss) and European eel (Anguilla anguilla), confirming a ubiquitous presence in the ray-finned (Actinopterygian) bony fish. The bony fish TGF-beta3 is highly conserved, with some 83-84% nucleotide identity (coding region) and 90-95% predicted amino acid identity to known homeotherm TGF-beta3's. Far lower homologies are apparent with other known TGF-beta isoforms in fish (e.g. 64-66% and 81-82% amino acid identity to trout TGF-beta 1/5 and carp TGF-beta2 respectively). Phylogenetic tree analysis showed that the fish TGF-beta3's clustered with the known homeotherm TGF-beta3's. The relatively tight clustering of TGF-beta1, TGF-beta2 and TGF-beta3 was in contrast to the TGF-beta5's, which are clearly a more heterogenous group.
PubMed: 10614492
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pubmed:10614492Le document en format XML
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<author><name sortKey="Laing, K J" sort="Laing, K J" uniqKey="Laing K" first="K J" last="Laing">K J Laing</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, University of Aberdeen, Aberdeen, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Aberdeen, Aberdeen</wicri:regionArea>
<wicri:noRegion>Aberdeen</wicri:noRegion>
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<author><name sortKey="Pilstrom, L" sort="Pilstrom, L" uniqKey="Pilstrom L" first="L" last="Pilström">L. Pilström</name>
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<author><name sortKey="Cunningham, C" sort="Cunningham, C" uniqKey="Cunningham C" first="C" last="Cunningham">C. Cunningham</name>
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<author><name sortKey="Secombes, C J" sort="Secombes, C J" uniqKey="Secombes C" first="C J" last="Secombes">C J Secombes</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">TGF-beta3 exists in bony fish.</title>
<author><name sortKey="Laing, K J" sort="Laing, K J" uniqKey="Laing K" first="K J" last="Laing">K J Laing</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, University of Aberdeen, Aberdeen, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Aberdeen, Aberdeen</wicri:regionArea>
<wicri:noRegion>Aberdeen</wicri:noRegion>
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<author><name sortKey="Pilstrom, L" sort="Pilstrom, L" uniqKey="Pilstrom L" first="L" last="Pilström">L. Pilström</name>
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<author><name sortKey="Cunningham, C" sort="Cunningham, C" uniqKey="Cunningham C" first="C" last="Cunningham">C. Cunningham</name>
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<author><name sortKey="Secombes, C J" sort="Secombes, C J" uniqKey="Secombes C" first="C J" last="Secombes">C J Secombes</name>
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<series><title level="j">Veterinary immunology and immunopathology</title>
<idno type="ISSN">0165-2427</idno>
<imprint><date when="1999" type="published">1999</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Anguilla (classification)</term>
<term>Anguilla (genetics)</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cloning, Molecular</term>
<term>DNA (chemistry)</term>
<term>DNA (isolation & purification)</term>
<term>DNA Primers (chemistry)</term>
<term>DNA Probes (chemistry)</term>
<term>Electrophoresis, Agar Gel (veterinary)</term>
<term>Fishes (classification)</term>
<term>Fishes (genetics)</term>
<term>Molecular Sequence Data</term>
<term>Oncorhynchus mykiss (classification)</term>
<term>Oncorhynchus mykiss (genetics)</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction (veterinary)</term>
<term>Sequence Alignment</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Transforming Growth Factor beta (chemistry)</term>
<term>Transforming Growth Factor beta (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term>
<term>DNA Primers</term>
<term>DNA Probes</term>
<term>Transforming Growth Factor beta</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Anguilla</term>
<term>Fishes</term>
<term>Oncorhynchus mykiss</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anguilla</term>
<term>Fishes</term>
<term>Oncorhynchus mykiss</term>
<term>Transforming Growth Factor beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Electrophoresis, Agar Gel</term>
<term>Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cloning, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Sequence Alignment</term>
<term>Sequence Analysis, DNA</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sequence Homology, Nucleic Acid</term>
</keywords>
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<front><div type="abstract" xml:lang="en">A partial nucleotide sequence of transforming growth factor-beta3 (TGF-beta3) has been isolated from the Siberian sturgeon (Acipenser baeri), rainbow trout (Oncorhynchus mykiss) and European eel (Anguilla anguilla), confirming a ubiquitous presence in the ray-finned (Actinopterygian) bony fish. The bony fish TGF-beta3 is highly conserved, with some 83-84% nucleotide identity (coding region) and 90-95% predicted amino acid identity to known homeotherm TGF-beta3's. Far lower homologies are apparent with other known TGF-beta isoforms in fish (e.g. 64-66% and 81-82% amino acid identity to trout TGF-beta 1/5 and carp TGF-beta2 respectively). Phylogenetic tree analysis showed that the fish TGF-beta3's clustered with the known homeotherm TGF-beta3's. The relatively tight clustering of TGF-beta1, TGF-beta2 and TGF-beta3 was in contrast to the TGF-beta5's, which are clearly a more heterogenous group.</div>
</front>
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