Length variation, heteroplasmy and sequence divergence in the mitochondrial DNA of four species of sturgeon (Acipenser).
Identifieur interne : 000878 ( Ncbi/Checkpoint ); précédent : 000877; suivant : 000879Length variation, heteroplasmy and sequence divergence in the mitochondrial DNA of four species of sturgeon (Acipenser).
Auteurs : J R Brown [Canada] ; K. Beckenbach ; A T Beckenbach ; M J SmithSource :
- Genetics [ 0016-6731 ] ; 1996.
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Abstract
The extent of mtDNA length variation and heteroplasmy as well as DNA sequences of the control region and two tRNA genes were determined for four North American sturgeon species: Acipenser transmontanus, A. medirostris, A. fulvescens and A. oxyrhnychus. Across the Continental Divide, a division in the occurrence of length variation and heteroplasmy was observed that was concordant with species biogeography as well as with phylogenies inferred from restriction fragment length polymorphisms (RFLP) of whole mtDNA and pairwise comparisons of unique sequences of the control region. In all species, mtDNA length variation was due to repeated arrays of 78-82-bp sequences each containing a D-loop strand synthesis termination associated sequence (TAS). Individual repeats showed greater sequence conservation within individuals and species rather than between species, which is suggestive of concerted evolution. Differences in the frequencies of multiple copy genomes and heteroplasmy among the four species may be ascribed to differences in the rates of recurrent mutation. A mechanism that may offset the high rate of mutation for increased copy number is suggested on the basis that an increase in the number of functional TAS motifs might reduce the frequency of successfully initiated H-strand replications.
PubMed: 8852850
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Beckenbach</name></author><author><name sortKey="Beckenbach, A T" sort="Beckenbach, A T" uniqKey="Beckenbach A" first="A T" last="Beckenbach">A T Beckenbach</name></author><author><name sortKey="Smith, M J" sort="Smith, M J" uniqKey="Smith M" first="M J" last="Smith">M J Smith</name></author></analytic><series><title level="j">Genetics</title><idno type="ISSN">0016-6731</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>DNA Primers</term><term>DNA, Mitochondrial</term><term>Fishes (genetics)</term><term>Genetic Variation</term><term>Molecular Sequence Data</term><term>Nucleic Acid Conformation</term><term>Phylogeny</term><term>RNA, Transfer</term><term>Repetitive Sequences, Nucleic Acid</term><term>Restriction Mapping</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Primers</term><term>DNA, Mitochondrial</term><term>RNA, Transfer</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Fishes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Genetic Variation</term><term>Molecular Sequence Data</term><term>Nucleic Acid Conformation</term><term>Phylogeny</term><term>Repetitive Sequences, Nucleic Acid</term><term>Restriction Mapping</term><term>Sequence Homology, Nucleic Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The extent of mtDNA length variation and heteroplasmy as well as DNA sequences of the control region and two tRNA genes were determined for four North American sturgeon species: Acipenser transmontanus, A. medirostris, A. fulvescens and A. oxyrhnychus. Across the Continental Divide, a division in the occurrence of length variation and heteroplasmy was observed that was concordant with species biogeography as well as with phylogenies inferred from restriction fragment length polymorphisms (RFLP) of whole mtDNA and pairwise comparisons of unique sequences of the control region. In all species, mtDNA length variation was due to repeated arrays of 78-82-bp sequences each containing a D-loop strand synthesis termination associated sequence (TAS). Individual repeats showed greater sequence conservation within individuals and species rather than between species, which is suggestive of concerted evolution. Differences in the frequencies of multiple copy genomes and heteroplasmy among the four species may be ascribed to differences in the rates of recurrent mutation. A mechanism that may offset the high rate of mutation for increased copy number is suggested on the basis that an increase in the number of functional TAS motifs might reduce the frequency of successfully initiated H-strand replications.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Beckenbach, A T" sort="Beckenbach, A T" uniqKey="Beckenbach A" first="A T" last="Beckenbach">A T Beckenbach</name><name sortKey="Beckenbach, K" sort="Beckenbach, K" uniqKey="Beckenbach K" first="K" last="Beckenbach">K. Beckenbach</name><name sortKey="Smith, M J" sort="Smith, M J" uniqKey="Smith M" first="M J" last="Smith">M J Smith</name></noCountry><country name="Canada"><noRegion><name sortKey="Brown, J R" sort="Brown, J R" uniqKey="Brown J" first="J R" last="Brown">J R Brown</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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