Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium.
Identifieur interne : 000729 ( Ncbi/Checkpoint ); précédent : 000728; suivant : 000730Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium.
Auteurs : Song Tang [Canada] ; Jon A. Doering [Canada] ; Jianxian Sun [Canada] ; Shawn C. Beitel [Canada] ; Kamran Shekh [Canada] ; Sarah Patterson [Canada] ; Sarah Crawford [Canada] ; John P. Giesy [Canada] ; Steve B. Wiseman [Canada] ; Markus Hecker [Canada]Source :
- Environmental science & technology [ 1520-5851 ] ; 2016.
Abstract
Sensitivity of white sturgeon (Acipenser transmontanus) to copper (Cu) or cadmium (Cd) has been shown to significantly differ as a function of life-stage. This study investigated oxidative stress, metal homeostasis, and associated compensatory responses as potential mechanisms of this sensitivity pattern in three early life-stages. Sturgeon were most sensitive to Cu at 15 days post hatch (dph), which was accompanied by a significant increase in lipid peroxidation (LPO). Genes involved with amelioration of oxidative stress were significantly less inducible at this stage than in older, less sensitive fry. At 48 dph, acute lethality of sturgeon exposed to Cd was greatest and body LPO was significantly induced by 3.5-fold at 5 μg Cd/L. Moreover, there was a small but significant increase in antioxidative responses. At 139 dph, sturgeon were most tolerant to Cu and Cd and accumulation of these metals was least. Also, expression of metallothionein (MT) and apoptotic genes were greatest while expression of metal transporters was reduced and concentration of LPO was not different from controls. Our results suggest that life-stage specific sensitivity of white sturgeon to metals is complex, encompassing differences in the ability to mount compensatory responses important for metal homeostasis and combating oxidative stress and concomitant damages.
DOI: 10.1021/acs.est.6b03301
PubMed: 27509013
Affiliations:
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Doering</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Jianxian" sort="Sun, Jianxian" uniqKey="Sun J" first="Jianxian" last="Sun">Jianxian Sun</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Beitel, Shawn C" sort="Beitel, Shawn C" uniqKey="Beitel S" first="Shawn C" last="Beitel">Shawn C. Beitel</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Shekh, Kamran" sort="Shekh, Kamran" uniqKey="Shekh K" first="Kamran" last="Shekh">Kamran Shekh</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Patterson, Sarah" sort="Patterson, Sarah" uniqKey="Patterson S" first="Sarah" last="Patterson">Sarah Patterson</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Crawford, Sarah" sort="Crawford, Sarah" uniqKey="Crawford S" first="Sarah" last="Crawford">Sarah Crawford</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Giesy, John P" sort="Giesy, John P" uniqKey="Giesy J" first="John P" last="Giesy">John P. Giesy</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Wiseman, Steve B" sort="Wiseman, Steve B" uniqKey="Wiseman S" first="Steve B" last="Wiseman">Steve B. Wiseman</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan , Saskatoon, SK S7N 5B3</wicri:regionArea><wicri:noRegion>SK S7N 5B3</wicri:noRegion></affiliation></author><author><name sortKey="Hecker, Markus" sort="Hecker, Markus" uniqKey="Hecker M" first="Markus" last="Hecker">Markus Hecker</name><affiliation wicri:level="1"><nlm:affiliation>School of Environment and Sustainability, University of Saskatchewan , Saskatoon, SK S7N 5C8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>School of Environment and Sustainability, University of Saskatchewan , Saskatoon, SK S7N 5C8</wicri:regionArea><wicri:noRegion>SK S7N 5C8</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental science & technology</title><idno type="eISSN">1520-5851</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sensitivity of white sturgeon (Acipenser transmontanus) to copper (Cu) or cadmium (Cd) has been shown to significantly differ as a function of life-stage. This study investigated oxidative stress, metal homeostasis, and associated compensatory responses as potential mechanisms of this sensitivity pattern in three early life-stages. Sturgeon were most sensitive to Cu at 15 days post hatch (dph), which was accompanied by a significant increase in lipid peroxidation (LPO). Genes involved with amelioration of oxidative stress were significantly less inducible at this stage than in older, less sensitive fry. At 48 dph, acute lethality of sturgeon exposed to Cd was greatest and body LPO was significantly induced by 3.5-fold at 5 μg Cd/L. Moreover, there was a small but significant increase in antioxidative responses. At 139 dph, sturgeon were most tolerant to Cu and Cd and accumulation of these metals was least. Also, expression of metallothionein (MT) and apoptotic genes were greatest while expression of metal transporters was reduced and concentration of LPO was not different from controls. Our results suggest that life-stage specific sensitivity of white sturgeon to metals is complex, encompassing differences in the ability to mount compensatory responses important for metal homeostasis and combating oxidative stress and concomitant damages.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Tang, Song" sort="Tang, Song" uniqKey="Tang S" first="Song" last="Tang">Song Tang</name></noRegion><name sortKey="Beitel, Shawn C" sort="Beitel, Shawn C" uniqKey="Beitel S" first="Shawn C" last="Beitel">Shawn C. Beitel</name><name sortKey="Crawford, Sarah" sort="Crawford, Sarah" uniqKey="Crawford S" first="Sarah" last="Crawford">Sarah Crawford</name><name sortKey="Doering, Jon A" sort="Doering, Jon A" uniqKey="Doering J" first="Jon A" last="Doering">Jon A. Doering</name><name sortKey="Giesy, John P" sort="Giesy, John P" uniqKey="Giesy J" first="John P" last="Giesy">John P. Giesy</name><name sortKey="Hecker, Markus" sort="Hecker, Markus" uniqKey="Hecker M" first="Markus" last="Hecker">Markus Hecker</name><name sortKey="Patterson, Sarah" sort="Patterson, Sarah" uniqKey="Patterson S" first="Sarah" last="Patterson">Sarah Patterson</name><name sortKey="Shekh, Kamran" sort="Shekh, Kamran" uniqKey="Shekh K" first="Kamran" last="Shekh">Kamran Shekh</name><name sortKey="Sun, Jianxian" sort="Sun, Jianxian" uniqKey="Sun J" first="Jianxian" last="Sun">Jianxian Sun</name><name sortKey="Wiseman, Steve B" sort="Wiseman, Steve B" uniqKey="Wiseman S" first="Steve B" last="Wiseman">Steve B. Wiseman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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