Exposure of Persian sturgeon (Acipenser persicus) to cadmium results in biochemical, histological and transcriptional alterations.
Identifieur interne : 000674 ( Ncbi/Checkpoint ); précédent : 000673; suivant : 000675Exposure of Persian sturgeon (Acipenser persicus) to cadmium results in biochemical, histological and transcriptional alterations.
Auteurs : Hamed Kolangi Miandare [Iran] ; Mahtab Niknejad [Iran] ; Ali Shabani [Iran] ; Roghieh Safari [Iran]Source :
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [ 1532-0456 ]
English descriptors
- KwdEn :
- Animals, Basic Helix-Loop-Helix Transcription Factors (genetics), Cadmium (toxicity), Ecotoxicology (methods), Endangered Species, Fish Proteins (genetics), Fishes, Gene Expression Regulation (drug effects), Gills (drug effects), Gills (pathology), Hydrocortisone (blood), Hypoxia-Inducible Factor 1, alpha Subunit (genetics), Vascular Endothelial Growth Factor A (genetics), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , blood : Hydrocortisone.
- chemical , genetics : Basic Helix-Loop-Helix Transcription Factors, Fish Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Vascular Endothelial Growth Factor A.
- chemical , toxicity : Cadmium, Water Pollutants, Chemical.
- drug effects : Gene Expression Regulation, Gills.
- methods : Ecotoxicology.
- pathology : Gills.
- Animals, Endangered Species, Fishes.
Abstract
Sturgeon is one of the endangered families of fish in the Caspian Sea region, where there is up to 80% of their global caching. Unfortunately, in recent years, increase of pollutants has been resulted in their total population reduction. Due to their benthic nature, sturgeons are at great risk of exposing to contaminants such as cadmium. Despite their endangered status in the Caspian Sea, there are only a few studies on characterizing the relative sensitivity of sturgeons to cadmium. Adverse effects associated with pollution on angiogenesis are mediated by hypoxia inducing factor-1 (HIF-1) and vascular endothelial growth factor (VEGF). In this investigation, gene expression of two distinct HIFs-1, HIF-1α and HIF-2α, and VEGF was investigated at the mRNA transcript levels after exposure of Persian sturgeon (Acipenser persicus) to cadmium. VEGF, HIF-1α and HIF-2α expressions in treated Persian sturgeon were greater than controls. Significant increases (P<0.05) were also observed in cortisol and glucose levels compared to the control group especially in the fish exposed to higher cadmium concentration (800 μg/L). Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid dehydrogenase (LDH) levels were increased in the cadmium-exposed fish, although the observed increases were not significant between the control and 200 μg/L cadmium treatment at some sampling time points. Gill tissues also showed histopathological changes in the cadmium treatments. Overall, results indicated that cadmium resulted in some alterations in biochemical parameters, mRNA transcript level expression of two important angiogenesis related genes as well as histological alterations in Persian sturgeon.
DOI: 10.1016/j.cbpc.2015.12.004
PubMed: 26687766
Affiliations:
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Electronic address: hkolangi@gau.ac.ir.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Niknejad, Mahtab" sort="Niknejad, Mahtab" uniqKey="Niknejad M" first="Mahtab" last="Niknejad">Mahtab Niknejad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Shabani, Ali" sort="Shabani, Ali" uniqKey="Shabani A" first="Ali" last="Shabani">Ali Shabani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Safari, Roghieh" sort="Safari, Roghieh" uniqKey="Safari R" first="Roghieh" last="Safari">Roghieh Safari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2016 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:26687766</idno><idno type="pmid">26687766</idno><idno type="doi">10.1016/j.cbpc.2015.12.004</idno><idno type="wicri:Area/PubMed/Corpus">000079</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000079</idno><idno type="wicri:Area/PubMed/Curation">000079</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000079</idno><idno type="wicri:Area/PubMed/Checkpoint">000079</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000079</idno><idno type="wicri:Area/Ncbi/Merge">000674</idno><idno type="wicri:Area/Ncbi/Curation">000674</idno><idno type="wicri:Area/Ncbi/Checkpoint">000674</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Exposure of Persian sturgeon (Acipenser persicus) to cadmium results in biochemical, histological and transcriptional alterations.</title><author><name sortKey="Miandare, Hamed Kolangi" sort="Miandare, Hamed Kolangi" uniqKey="Miandare H" first="Hamed Kolangi" last="Miandare">Hamed Kolangi Miandare</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address: hkolangi@gau.ac.ir.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Niknejad, Mahtab" sort="Niknejad, Mahtab" uniqKey="Niknejad M" first="Mahtab" last="Niknejad">Mahtab Niknejad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Shabani, Ali" sort="Shabani, Ali" uniqKey="Shabani A" first="Ali" last="Shabani">Ali Shabani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author><author><name sortKey="Safari, Roghieh" sort="Safari, Roghieh" uniqKey="Safari R" first="Roghieh" last="Safari">Roghieh Safari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan</wicri:regionArea><wicri:noRegion>Gorgan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Comparative biochemistry and physiology. Toxicology & pharmacology : CBP</title><idno type="ISSN">1532-0456</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Basic Helix-Loop-Helix Transcription Factors (genetics)</term><term>Cadmium (toxicity)</term><term>Ecotoxicology (methods)</term><term>Endangered Species</term><term>Fish Proteins (genetics)</term><term>Fishes</term><term>Gene Expression Regulation (drug effects)</term><term>Gills (drug effects)</term><term>Gills (pathology)</term><term>Hydrocortisone (blood)</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (genetics)</term><term>Vascular Endothelial Growth Factor A (genetics)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Basic Helix-Loop-Helix Transcription Factors</term><term>Fish Proteins</term><term>Hypoxia-Inducible Factor 1, alpha Subunit</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Gills</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ecotoxicology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gills</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Endangered Species</term><term>Fishes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sturgeon is one of the endangered families of fish in the Caspian Sea region, where there is up to 80% of their global caching. Unfortunately, in recent years, increase of pollutants has been resulted in their total population reduction. Due to their benthic nature, sturgeons are at great risk of exposing to contaminants such as cadmium. Despite their endangered status in the Caspian Sea, there are only a few studies on characterizing the relative sensitivity of sturgeons to cadmium. Adverse effects associated with pollution on angiogenesis are mediated by hypoxia inducing factor-1 (HIF-1) and vascular endothelial growth factor (VEGF). In this investigation, gene expression of two distinct HIFs-1, HIF-1α and HIF-2α, and VEGF was investigated at the mRNA transcript levels after exposure of Persian sturgeon (Acipenser persicus) to cadmium. VEGF, HIF-1α and HIF-2α expressions in treated Persian sturgeon were greater than controls. Significant increases (P<0.05) were also observed in cortisol and glucose levels compared to the control group especially in the fish exposed to higher cadmium concentration (800 μg/L). Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid dehydrogenase (LDH) levels were increased in the cadmium-exposed fish, although the observed increases were not significant between the control and 200 μg/L cadmium treatment at some sampling time points. Gill tissues also showed histopathological changes in the cadmium treatments. Overall, results indicated that cadmium resulted in some alterations in biochemical parameters, mRNA transcript level expression of two important angiogenesis related genes as well as histological alterations in Persian sturgeon.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Miandare, Hamed Kolangi" sort="Miandare, Hamed Kolangi" uniqKey="Miandare H" first="Hamed Kolangi" last="Miandare">Hamed Kolangi Miandare</name></noRegion><name sortKey="Niknejad, Mahtab" sort="Niknejad, Mahtab" uniqKey="Niknejad M" first="Mahtab" last="Niknejad">Mahtab Niknejad</name><name sortKey="Safari, Roghieh" sort="Safari, Roghieh" uniqKey="Safari R" first="Roghieh" last="Safari">Roghieh Safari</name><name sortKey="Shabani, Ali" sort="Shabani, Ali" uniqKey="Shabani A" first="Ali" last="Shabani">Ali Shabani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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