Alpha-tocopherol downregulates gulonolactone oxidase activity in sturgeon.
Identifieur interne : 000089 ( Ncbi/Checkpoint ); précédent : 000088; suivant : 000090Alpha-tocopherol downregulates gulonolactone oxidase activity in sturgeon.
Auteurs : Régis Moreau [États-Unis] ; Konrad DabrowskiSource :
- Free radical biology & medicine [ 0891-5849 ] ; 2003.
English descriptors
- KwdEn :
- Animals, Antioxidants (metabolism), Antioxidants (pharmacology), Ascorbic Acid (pharmacology), Ascorbic Acid Deficiency, Diet, Down-Regulation, Fishes (physiology), Kidney (drug effects), Kidney (enzymology), L-Gulonolactone Oxidase, Liver (drug effects), Liver (enzymology), Sugar Alcohol Dehydrogenases (metabolism), Survival Rate, alpha-Tocopherol (metabolism), alpha-Tocopherol (pharmacology).
- MESH :
- chemical , metabolism : Antioxidants, Sugar Alcohol Dehydrogenases, alpha-Tocopherol.
- chemical , pharmacology : Antioxidants, Ascorbic Acid, alpha-Tocopherol.
- drug effects : Kidney, Liver.
- enzymology : Kidney, Liver.
- physiology : Fishes.
- Animals, Ascorbic Acid Deficiency, Diet, Down-Regulation, L-Gulonolactone Oxidase, Survival Rate.
Abstract
Gulonolactone oxidase (GLO) is the enzyme responsible for the last step of ascorbic acid biosynthesis. The aim of this study was to investigate the effect of dietary alpha-tocopherol and ascorbic acid on GLO activity in a lower vertebrate, the white sturgeon (Acipenser transmontanus). Both alpha-tocopherol and ascorbic acid modulated renal GLO activity. The increase of dietary levels of alpha-tocopherol and/or ascorbic acid significantly raised the liver concentrations of these two antioxidants and concomitantly lowered kidney's GLO activity. The results suggest that the enzyme of ascorbic acid synthetic pathway responded to the animal's antioxidant status and that its activity was downregulated by alpha-tocopherol. This is the first record of alpha-tocopherol being involved in the regulation of ascorbic acid synthesis. This new observation may provide a hypothesis for the evolutionary loss of GLO expression in teleost fishes.
PubMed: 12726920
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000585
- to stream PubMed, to step Curation: 000585
- to stream PubMed, to step Checkpoint: 000585
- to stream Ncbi, to step Merge: 000089
- to stream Ncbi, to step Curation: 000089
Links to Exploration step
pubmed:12726920Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alpha-tocopherol downregulates gulonolactone oxidase activity in sturgeon.</title>
<author><name sortKey="Moreau, Regis" sort="Moreau, Regis" uniqKey="Moreau R" first="Régis" last="Moreau">Régis Moreau</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Natural Resources, The Ohio State University, Columbus OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Natural Resources, The Ohio State University, Columbus OH</wicri:regionArea>
<wicri:noRegion>Columbus OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dabrowski, Konrad" sort="Dabrowski, Konrad" uniqKey="Dabrowski K" first="Konrad" last="Dabrowski">Konrad Dabrowski</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:12726920</idno>
<idno type="pmid">12726920</idno>
<idno type="wicri:Area/PubMed/Corpus">000585</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000585</idno>
<idno type="wicri:Area/PubMed/Curation">000585</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000585</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000585</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000585</idno>
<idno type="wicri:Area/Ncbi/Merge">000089</idno>
<idno type="wicri:Area/Ncbi/Curation">000089</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000089</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Alpha-tocopherol downregulates gulonolactone oxidase activity in sturgeon.</title>
<author><name sortKey="Moreau, Regis" sort="Moreau, Regis" uniqKey="Moreau R" first="Régis" last="Moreau">Régis Moreau</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Natural Resources, The Ohio State University, Columbus OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Natural Resources, The Ohio State University, Columbus OH</wicri:regionArea>
<wicri:noRegion>Columbus OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dabrowski, Konrad" sort="Dabrowski, Konrad" uniqKey="Dabrowski K" first="Konrad" last="Dabrowski">Konrad Dabrowski</name>
</author>
</analytic>
<series><title level="j">Free radical biology & medicine</title>
<idno type="ISSN">0891-5849</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antioxidants (metabolism)</term>
<term>Antioxidants (pharmacology)</term>
<term>Ascorbic Acid (pharmacology)</term>
<term>Ascorbic Acid Deficiency</term>
<term>Diet</term>
<term>Down-Regulation</term>
<term>Fishes (physiology)</term>
<term>Kidney (drug effects)</term>
<term>Kidney (enzymology)</term>
<term>L-Gulonolactone Oxidase</term>
<term>Liver (drug effects)</term>
<term>Liver (enzymology)</term>
<term>Sugar Alcohol Dehydrogenases (metabolism)</term>
<term>Survival Rate</term>
<term>alpha-Tocopherol (metabolism)</term>
<term>alpha-Tocopherol (pharmacology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term>
<term>Sugar Alcohol Dehydrogenases</term>
<term>alpha-Tocopherol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term>
<term>Ascorbic Acid</term>
<term>alpha-Tocopherol</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Kidney</term>
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fishes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Ascorbic Acid Deficiency</term>
<term>Diet</term>
<term>Down-Regulation</term>
<term>L-Gulonolactone Oxidase</term>
<term>Survival Rate</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Gulonolactone oxidase (GLO) is the enzyme responsible for the last step of ascorbic acid biosynthesis. The aim of this study was to investigate the effect of dietary alpha-tocopherol and ascorbic acid on GLO activity in a lower vertebrate, the white sturgeon (Acipenser transmontanus). Both alpha-tocopherol and ascorbic acid modulated renal GLO activity. The increase of dietary levels of alpha-tocopherol and/or ascorbic acid significantly raised the liver concentrations of these two antioxidants and concomitantly lowered kidney's GLO activity. The results suggest that the enzyme of ascorbic acid synthetic pathway responded to the animal's antioxidant status and that its activity was downregulated by alpha-tocopherol. This is the first record of alpha-tocopherol being involved in the regulation of ascorbic acid synthesis. This new observation may provide a hypothesis for the evolutionary loss of GLO expression in teleost fishes.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Dabrowski, Konrad" sort="Dabrowski, Konrad" uniqKey="Dabrowski K" first="Konrad" last="Dabrowski">Konrad Dabrowski</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Moreau, Regis" sort="Moreau, Regis" uniqKey="Moreau R" first="Régis" last="Moreau">Régis Moreau</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000089 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000089 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Eau |area= EsturgeonV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:12726920 |texte= Alpha-tocopherol downregulates gulonolactone oxidase activity in sturgeon. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:12726920" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a EsturgeonV1
This area was generated with Dilib version V0.6.27. |