Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: An immunohistochemical study
Identifieur interne : 000C15 ( Main/Merge ); précédent : 000C14; suivant : 000C16Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: An immunohistochemical study
Auteurs : Henry J. Waldvogel [Nouvelle-Zélande] ; Kristin Baer [Royaume-Uni] ; Kathryn L. Allen [Nouvelle-Zélande] ; Mark I. Rees [Royaume-Uni] ; Richard L. M. Faull [Nouvelle-Zélande]Source :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2007-06-20.
English descriptors
Abstract
Glycine receptors (GlyRs) are heteropentameric chloride ion channels that facilitate fast‐response, inhibitory neurotransmission in the mammalian spinal cord and brain. GlyRs have four functional subunits, α1–3 and β, which likely exist in heteromeric αβ combinations. Mutations in GlyR α1 and β subunits are well known for their involvement in hyperekplexia, a paroxysmal motor disorder. In this study we present the first detailed immunohistochemical investigation at the regional, cellular, and subcellular levels of GlyRs in the human basal ganglia. The results show that GlyRs are present at the regional level in low concentrations in the striatum and globus pallidus and are present in the highest concentrations in the substantia nigra. At the cellular level, GlyRs are present only in discrete populations of neurons immunoreactive for choline acetyltransferase (ChAT), parvalbumin, and calretinin in the human striatum, on a subpopulation of parvalbumin‐ and calretinin‐positive neurons in the globus pallidus, and in the substantia nigra GlyRs are present on approximately three‐fourths of all pars compacta and one‐third of all pars reticulata neurons. They also form a distinct band of immunoreactive neurons in the intermedullary layers of the globus pallidus. At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of γ‐aminobutyric acid (GABA)A receptors. Our results demonstrate the precise cellular and subcellular localization of GlyRs in the human basal ganglia and suggest that glycinergic receptors may play an important complementary role to other inhibitory receptors in modulating cholinergic, dopaminergic, and GABAergic neuronal pathways in the basal ganglia. J. Comp. Neurol. 502:1012–1029, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/cne.21349
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001398
- to stream Istex, to step Curation: 001396
- to stream Istex, to step Checkpoint: 000580
Links to Exploration step
ISTEX:CCC95D9F2341D48A533DEF3501D6EC46E11B9C24Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: An immunohistochemical study</title><author><name sortKey="Waldvogel, Henry J" sort="Waldvogel, Henry J" uniqKey="Waldvogel H" first="Henry J." last="Waldvogel">Henry J. Waldvogel</name></author><author><name sortKey="Baer, Kristin" sort="Baer, Kristin" uniqKey="Baer K" first="Kristin" last="Baer">Kristin Baer</name></author><author><name sortKey="Allen, Kathryn L" sort="Allen, Kathryn L" uniqKey="Allen K" first="Kathryn L." last="Allen">Kathryn L. Allen</name></author><author><name sortKey="Rees, Mark I" sort="Rees, Mark I" uniqKey="Rees M" first="Mark I." last="Rees">Mark I. Rees</name></author><author><name sortKey="Faull, Richard L M" sort="Faull, Richard L M" uniqKey="Faull R" first="Richard L. M." last="Faull">Richard L. M. Faull</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CCC95D9F2341D48A533DEF3501D6EC46E11B9C24</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/cne.21349</idno><idno type="url">https://api.istex.fr/document/CCC95D9F2341D48A533DEF3501D6EC46E11B9C24/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001398</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001398</idno><idno type="wicri:Area/Istex/Curation">001396</idno><idno type="wicri:Area/Istex/Checkpoint">000580</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000580</idno><idno type="wicri:doubleKey">0021-9967:2007:Waldvogel H:glycine:receptors:in</idno><idno type="wicri:Area/Main/Merge">000C15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: An immunohistochemical study</title><author><name sortKey="Waldvogel, Henry J" sort="Waldvogel, Henry J" uniqKey="Waldvogel H" first="Henry J." last="Waldvogel">Henry J. Waldvogel</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Anatomy with Radiology, Faculty of Medical and Health Science, University of Auckland, Auckland 1148</wicri:regionArea><wicri:noRegion>Auckland 1148</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Anatomy with Radiology, Faculty of Medical and Health Science, University of Auckland, Private Bag 92019, Auckland 1148</wicri:regionArea><wicri:noRegion>Auckland 1148</wicri:noRegion></affiliation></author><author><name sortKey="Baer, Kristin" sort="Baer, Kristin" uniqKey="Baer K" first="Kristin" last="Baer">Kristin Baer</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Neuroscience, School of Medicine, Swansea University, Swansea SA2 8PP, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Allen, Kathryn L" sort="Allen, Kathryn L" uniqKey="Allen K" first="Kathryn L." last="Allen">Kathryn L. Allen</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Anatomy with Radiology, Faculty of Medical and Health Science, University of Auckland, Auckland 1148</wicri:regionArea><wicri:noRegion>Auckland 1148</wicri:noRegion></affiliation></author><author><name sortKey="Rees, Mark I" sort="Rees, Mark I" uniqKey="Rees M" first="Mark I." last="Rees">Mark I. Rees</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular Neuroscience, School of Medicine, Swansea University, Swansea SA2 8PP, Wales</wicri:regionArea><wicri:noRegion>Wales</wicri:noRegion></affiliation></author><author><name sortKey="Faull, Richard L M" sort="Faull, Richard L M" uniqKey="Faull R" first="Richard L. M." last="Faull">Richard L. M. Faull</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Anatomy with Radiology, Faculty of Medical and Health Science, University of Auckland, Auckland 1148</wicri:regionArea><wicri:noRegion>Auckland 1148</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Comparative Neurology</title><title level="j" type="abbrev">J. Comp. Neurol.</title><idno type="ISSN">0021-9967</idno><idno type="eISSN">1096-9861</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-20">2007-06-20</date><biblScope unit="volume">502</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1012">1012</biblScope><biblScope unit="page" to="1029">1029</biblScope></imprint><idno type="ISSN">0021-9967</idno></series><idno type="istex">CCC95D9F2341D48A533DEF3501D6EC46E11B9C24</idno><idno type="DOI">10.1002/cne.21349</idno><idno type="ArticleID">CNE21349</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal ganglia</term><term>glycine receptor</term><term>human brain</term><term>immunohistochemistry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glycine receptors (GlyRs) are heteropentameric chloride ion channels that facilitate fast‐response, inhibitory neurotransmission in the mammalian spinal cord and brain. GlyRs have four functional subunits, α1–3 and β, which likely exist in heteromeric αβ combinations. Mutations in GlyR α1 and β subunits are well known for their involvement in hyperekplexia, a paroxysmal motor disorder. In this study we present the first detailed immunohistochemical investigation at the regional, cellular, and subcellular levels of GlyRs in the human basal ganglia. The results show that GlyRs are present at the regional level in low concentrations in the striatum and globus pallidus and are present in the highest concentrations in the substantia nigra. At the cellular level, GlyRs are present only in discrete populations of neurons immunoreactive for choline acetyltransferase (ChAT), parvalbumin, and calretinin in the human striatum, on a subpopulation of parvalbumin‐ and calretinin‐positive neurons in the globus pallidus, and in the substantia nigra GlyRs are present on approximately three‐fourths of all pars compacta and one‐third of all pars reticulata neurons. They also form a distinct band of immunoreactive neurons in the intermedullary layers of the globus pallidus. At the subcellular level in the substantia nigra pars reticulata (SNr), GlyRs show a localized distribution on the soma and dendrites that partially complements but does not overlap with the distribution of γ‐aminobutyric acid (GABA)A receptors. Our results demonstrate the precise cellular and subcellular localization of GlyRs in the human basal ganglia and suggest that glycinergic receptors may play an important complementary role to other inhibitory receptors in modulating cholinergic, dopaminergic, and GABAergic neuronal pathways in the basal ganglia. J. Comp. Neurol. 502:1012–1029, 2007. © 2007 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C15 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000C15 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Eau
|area= EsturgeonV1
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:CCC95D9F2341D48A533DEF3501D6EC46E11B9C24
|texte= Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: An immunohistochemical study
}}
| This area was generated with Dilib version V0.6.27. |  |