The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758.
Identifieur interne : 000B69 ( Main/Merge ); précédent : 000B68; suivant : 000B70The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758.
Auteurs : S. Wuertz [Allemagne] ; A. Nitsche ; M. Jastroch ; J. Gessner ; M. Klingenspor ; F. Kirschbaum ; W. KloasSource :
- General and comparative endocrinology [ 0016-6480 ] ; 2007.
English descriptors
- KwdEn :
- Animals, Base Sequence, Female, Fishes (genetics), Fishes (physiology), Gene Expression Regulation, Insulin-Like Growth Factor I (genetics), Insulin-Like Growth Factor I (physiology), Molecular Sequence Data, Ovulation (physiology), RNA, Messenger (analysis), Receptor, IGF Type 1 (genetics), Receptor, IGF Type 1 (metabolism), Sequence Homology, Sexual Maturation (physiology), Species Specificity, Vitellogenesis (physiology).
- MESH :
- chemical , analysis : RNA, Messenger.
- chemical , genetics : Insulin-Like Growth Factor I, Receptor, IGF Type 1.
- genetics : Fishes.
- chemical , metabolism : Receptor, IGF Type 1.
- physiology : Fishes, Insulin-Like Growth Factor I, Ovulation, Sexual Maturation, Vitellogenesis.
- Animals, Base Sequence, Female, Gene Expression Regulation, Molecular Sequence Data, Sequence Homology, Species Specificity.
Abstract
Transition from previtellogeneic to vitellogenic oocyte growth is a critical phase for folliculogenesis in sturgeon and may often be postponed for several years. Recent findings on the involvement of insulin-like growth factor I (IGF-I) in cell differentiation processes of oocyte follicle and ovarian steroidogenesis of teleosts in vitro led to the hypothesis that paracrine IGF-I could function as a potential trigger in vivo. For the first time, IGF-I and its corresponding receptor (IGF-IR) were identified in a non-teleostean fish. Real-time PCR assays for IGF-I and IGF-IR mRNA were established, normalising mRNA expression of the target genes to beta-microglobulin (beta2m). We clearly show that expression of IGF-I in the gonad is a substantial source for IGF-I-mediated effects in follicles compared to liver, brain, muscle and adipose tissue. Among these tissues, IGF-IR mRNA was highest in the gonad. With regard to different cohorts of coexisting follicles, highest expression of IGF-I and IGF-IR were met in developing follicles, indicating that IGF-I functions as an intraovarian modulator of follicle faith. Comparing previtellogenic follicles in females that matured within two years with non-maturing females f the same age, revealed an increases of 2.3-fold for IGF-I and 2.8-fold for IGF-IR mRNA expression in maturing females. These findings implicate an important role of paracrine IGF-I in early vitellogenesis and identify it as candidate vitellogenesis inducing factor (VIF), determining the faith of the follicle.
DOI: 10.1016/j.ygcen.2006.07.005
PubMed: 16945369
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pubmed:16945369Le document en format XML
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Recent findings on the involvement of insulin-like growth factor I (IGF-I) in cell differentiation processes of oocyte follicle and ovarian steroidogenesis of teleosts in vitro led to the hypothesis that paracrine IGF-I could function as a potential trigger in vivo. For the first time, IGF-I and its corresponding receptor (IGF-IR) were identified in a non-teleostean fish. Real-time PCR assays for IGF-I and IGF-IR mRNA were established, normalising mRNA expression of the target genes to beta-microglobulin (beta2m). We clearly show that expression of IGF-I in the gonad is a substantial source for IGF-I-mediated effects in follicles compared to liver, brain, muscle and adipose tissue. Among these tissues, IGF-IR mRNA was highest in the gonad. With regard to different cohorts of coexisting follicles, highest expression of IGF-I and IGF-IR were met in developing follicles, indicating that IGF-I functions as an intraovarian modulator of follicle faith. Comparing previtellogenic follicles in females that matured within two years with non-maturing females f the same age, revealed an increases of 2.3-fold for IGF-I and 2.8-fold for IGF-IR mRNA expression in maturing females. These findings implicate an important role of paracrine IGF-I in early vitellogenesis and identify it as candidate vitellogenesis inducing factor (VIF), determining the faith of the follicle.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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