Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus).
Identifieur interne : 000904 ( Main/Merge ); précédent : 000903; suivant : 000905Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus).
Auteurs : Amanda J. Palumbo [États-Unis] ; Michael S. Denison ; Serge I. Doroshov ; Ronald S. TjeerdemaSource :
- Environmental toxicology and chemistry [ 0730-7268 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , agonists : Receptors, Aryl Hydrocarbon.
- chemical , biosynthesis : Vitellogenins.
- chemical , metabolism : Cytochrome P-450 CYP1A1.
- chemical , pharmacology : Estradiol, Phenols.
- metabolism : Fishes, Microsomes, Liver.
- Animals, Down-Regulation.
Abstract
Migrating white sturgeon (Acipenser transmontamus) may be subject to agricultural, municipal, and industrial wastewater effluents that likely contain different classes of endocrine-disrupting contaminants. Concern is mounting about the negative effects of environmental estrogens on fish reproduction; however, in environmental mixtures, the affects from estrogenic compounds may be suppressed by aryl hydrocarbon receptor (AhR) ligands. Indeed, reductions in 17beta-estradiol-induced (0.01 and 1 mg/kg) vitellogenin (VTG) levels were observed in white sturgeon coinjected with beta-naphthoflavone (BNF; 50 mg/kg), a model for contaminants that activate the AhR. Variation in the time of injection was used to attempt to correlate VTG inhibition to ethoxyresorufin-O-deethylase activity. No evidence was found to suggest that the inhibition of VTG is a direct result of enhanced estrogen metabolism by BNF-induced enzymes. Results of the present study are relevant for monitoring programs that measure VTG, because these results show that AhR-active environmental contaminants can repress VTG synthesis, which commonly is used as an indicator of estrogen-mimicking contaminants. Furthermore, suppression of natural estrogen signaling by AhR agonists may have significant effects on fish reproduction.
DOI: 10.1897/08-481.1
PubMed: 19292566
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus).</title><author><name sortKey="Palumbo, Amanda J" sort="Palumbo, Amanda J" uniqKey="Palumbo A" first="Amanda J" last="Palumbo">Amanda J. Palumbo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California 95616, USA. ajpalumbo@ucdavis.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California 95616</wicri:regionArea><wicri:noRegion>California 95616</wicri:noRegion></affiliation></author><author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name></author><author><name sortKey="Doroshov, Serge I" sort="Doroshov, Serge I" uniqKey="Doroshov S" first="Serge I" last="Doroshov">Serge I. Doroshov</name></author><author><name sortKey="Tjeerdema, Ronald S" sort="Tjeerdema, Ronald S" uniqKey="Tjeerdema R" first="Ronald S" last="Tjeerdema">Ronald S. 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Palumbo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California 95616, USA. ajpalumbo@ucdavis.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California 95616</wicri:regionArea><wicri:noRegion>California 95616</wicri:noRegion></affiliation></author><author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name></author><author><name sortKey="Doroshov, Serge I" sort="Doroshov, Serge I" uniqKey="Doroshov S" first="Serge I" last="Doroshov">Serge I. Doroshov</name></author><author><name sortKey="Tjeerdema, Ronald S" sort="Tjeerdema, Ronald S" uniqKey="Tjeerdema R" first="Ronald S" last="Tjeerdema">Ronald S. Tjeerdema</name></author></analytic><series><title level="j">Environmental toxicology and chemistry</title><idno type="ISSN">0730-7268</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cytochrome P-450 CYP1A1 (metabolism)</term><term>Down-Regulation</term><term>Estradiol (pharmacology)</term><term>Fishes (metabolism)</term><term>Microsomes, Liver (metabolism)</term><term>Phenols (pharmacology)</term><term>Receptors, Aryl Hydrocarbon (agonists)</term><term>Vitellogenins (biosynthesis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Receptors, Aryl Hydrocarbon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Vitellogenins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytochrome P-450 CYP1A1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estradiol</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fishes</term><term>Microsomes, Liver</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Down-Regulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Migrating white sturgeon (Acipenser transmontamus) may be subject to agricultural, municipal, and industrial wastewater effluents that likely contain different classes of endocrine-disrupting contaminants. Concern is mounting about the negative effects of environmental estrogens on fish reproduction; however, in environmental mixtures, the affects from estrogenic compounds may be suppressed by aryl hydrocarbon receptor (AhR) ligands. Indeed, reductions in 17beta-estradiol-induced (0.01 and 1 mg/kg) vitellogenin (VTG) levels were observed in white sturgeon coinjected with beta-naphthoflavone (BNF; 50 mg/kg), a model for contaminants that activate the AhR. Variation in the time of injection was used to attempt to correlate VTG inhibition to ethoxyresorufin-O-deethylase activity. No evidence was found to suggest that the inhibition of VTG is a direct result of enhanced estrogen metabolism by BNF-induced enzymes. Results of the present study are relevant for monitoring programs that measure VTG, because these results show that AhR-active environmental contaminants can repress VTG synthesis, which commonly is used as an indicator of estrogen-mimicking contaminants. Furthermore, suppression of natural estrogen signaling by AhR agonists may have significant effects on fish reproduction.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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