Esquisse de l'evolution des hormones gonadotropes et thyreotropes des vertébrés
Identifieur interne : 002142 ( Main/Exploration ); précédent : 002141; suivant : 002143Esquisse de l'evolution des hormones gonadotropes et thyreotropes des vertébrés
Auteurs : Yves-Alain Fontaine [France] ; Elisabeth Burzawa-Gerard [France]Source :
- General and Comparative Endocrinology [ 0016-6480 ] ; 1977.
Abstract
Abstract: Results from comparative endocrinology, from structural studies on mammalian hormones, and classical data of vertebrate phylogeny have been used to outline the evolution of thyrotropic (TSH) and gonadotropic (GTH) hormones. The main hypotheses are as follows. A common ancestral molecule gave rise, by genic duplication, to two subunits α and β. The first hormone (α-β) was gonadotropic but later had both functions (TSH and GTH). Duplication of β then gave rise to β1 (with gonadotropic, LH-type, potentialities) and β2 (with thyrotropic potentialities). Finally the FSH β-type subunit originated later from a duplication of β2. Along these lines, hormonal specializations and diversifications occurred, due to genic modifications and associated structural changes in both α and β subunits.
Url:
DOI: 10.1016/0016-6480(77)90213-1
Affiliations:
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The main hypotheses are as follows. A common ancestral molecule gave rise, by genic duplication, to two subunits α and β. The first hormone (α-β) was gonadotropic but later had both functions (TSH and GTH). Duplication of β then gave rise to β1 (with gonadotropic, LH-type, potentialities) and β2 (with thyrotropic potentialities). Finally the FSH β-type subunit originated later from a duplication of β2. Along these lines, hormonal specializations and diversifications occurred, due to genic modifications and associated structural changes in both α and β subunits.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Fontaine, Yves Alain" sort="Fontaine, Yves Alain" uniqKey="Fontaine Y" first="Yves-Alain" last="Fontaine">Yves-Alain Fontaine</name></region><name sortKey="Burzawa Gerard, Elisabeth" sort="Burzawa Gerard, Elisabeth" uniqKey="Burzawa Gerard E" first="Elisabeth" last="Burzawa-Gerard">Elisabeth Burzawa-Gerard</name><name sortKey="Burzawa Gerard, Elisabeth" sort="Burzawa Gerard, Elisabeth" uniqKey="Burzawa Gerard E" first="Elisabeth" last="Burzawa-Gerard">Elisabeth Burzawa-Gerard</name><name sortKey="Fontaine, Yves Alain" sort="Fontaine, Yves Alain" uniqKey="Fontaine Y" first="Yves-Alain" last="Fontaine">Yves-Alain Fontaine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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