Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function
Identifieur interne : 000E99 ( Main/Exploration ); précédent : 000E98; suivant : 000F00Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function
Auteurs : E. Jirillo [Italie] ; L. Passantino [Italie] ; M. R. Ribaud [Italie] ; G. F. Passantino [Italie]Source :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.
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DOI: 10.1111/j.1439-0264.2005.00669_51.x
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Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function</title><author><name sortKey="Jirillo, E" sort="Jirillo, E" uniqKey="Jirillo E" first="E." last="Jirillo">E. Jirillo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, Immunology and Infectious Disease, Section of Microbiology and Immunology, Faculty of Medicine, University of Bari, Policlinico ‐Piazza G. Cesare‐ 70124 – Bari</wicri:regionArea><wicri:noRegion>Policlinico ‐Piazza G. Cesare‐ 70124 – Bari</wicri:noRegion></affiliation></author><author><name sortKey="Passantino, L" sort="Passantino, L" uniqKey="Passantino L" first="L." last="Passantino">L. Passantino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. 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Prov.le per Casamassima Km 3, 70010, Valenzano (BA)</wicri:regionArea><wicri:noRegion>Valenzano (BA)</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Anatomia, Histologia, Embryologia</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="24">24</biblScope></imprint><idno type="ISSN">0340-2096</idno></series><idno type="istex">028F96085D75B34D3D8465B67D272BA7F9DBF4F7</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_51.x</idno><idno type="ArticleID">AHE669_51_51</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Jirillo, E" sort="Jirillo, E" uniqKey="Jirillo E" first="E." last="Jirillo">E. Jirillo</name></noRegion><name sortKey="Passantino, G F" sort="Passantino, G F" uniqKey="Passantino G" first="G. F." last="Passantino">G. F. Passantino</name><name sortKey="Passantino, L" sort="Passantino, L" uniqKey="Passantino L" first="L." last="Passantino">L. Passantino</name><name sortKey="Ribaud, M R" sort="Ribaud, M R" uniqKey="Ribaud M" first="M. R." last="Ribaud">M. R. Ribaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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