Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost
Identifieur interne : 001339 ( Istex/Corpus ); précédent : 001338; suivant : 001340Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost
Auteurs : Mercedes Arochena ; Ram N Anad N ; Sofía M. Díaz-RegueiraSource :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2004-02-09.
English descriptors
Abstract
Previous studies in teleosts have revealed the presence of the intermediate filaments vimentin (Vim) and glial fibrillary acidic protein (GFAP) in glial cells of the spinal cord and/or some brain regions, but there is no comprehensive study of their distribution and developmental changes in fishes. Here, the distribution of Vim and GFAP immunoreactivities was studied in the brain of larvae, juveniles, and adults of an advanced teleost, the gray mullet (Chelon labrosus). A different sequence of appearance was observed for expression of these proteins: Vim levels decreased with age, whereas GFAP increased. In general, both immunoreactivities were expressed early in perikarya and endfeet of ependymocytes (tanycytes), whereas expression in radial processes appeared later. In large larvae, the similar expression patterns of Vim and GFAP suggest that some of these glial cells contain both proteins. Subependymal radial glia cells were observed mainly in the optic tectum, exhibiting Vim and GFAP immunoreactivity. The only immunoreactive cells with astrocyte‐like morphology were observed in the optic chiasm of the adult, and they were positive for both GFAP and Vim. The perivascular processes of glial cells showed a different distribution of Vim and GFAP during development and had a caudorostral sequence of appearance of immunoreactivities similar to that observed for ependymal and radial glia cells. Several circumventricular organs (the organon vasculosum hypothalami, saccus vasculosus, and area postrema) exhibited highly specialized Vim‐ and/or GFAP‐expressing glial cells. The glial cells of the midline septa of several brain regions were also Vim and/or GFAP immunoreactive. In the adult brain, tanycytes retain Vim expression in several brain regions. As in other vertebrates, the regions with Vim‐immunoreactive ventricular and midline glia may represent areas with the capability of plasticity and regeneration in adult brain. J. Comp. Neurol. 469:413–436, 2004. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/cne.11021
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<keyword xml:id="kwd3">immunocytochemistry</keyword>
<keyword xml:id="kwd4">radial glia</keyword>
<keyword xml:id="kwd5">tanycytes</keyword>
<keyword xml:id="kwd6">teleosts</keyword>
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<fundingInfo><fundingAgency>Spanish Science and Technology Ministry</fundingAgency>
<fundingNumber>BXX2000‐0453‐C02‐01</fundingNumber>
<fundingNumber>BXX2000‐0453‐C02‐01</fundingNumber>
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<fundingInfo><fundingAgency>Xunta de Galicia</fundingAgency>
<fundingNumber>PGIDT99BIO20002</fundingNumber>
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<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Previous studies in teleosts have revealed the presence of the intermediate filaments vimentin (Vim) and glial fibrillary acidic protein (GFAP) in glial cells of the spinal cord and/or some brain regions, but there is no comprehensive study of their distribution and developmental changes in fishes. Here, the distribution of Vim and GFAP immunoreactivities was studied in the brain of larvae, juveniles, and adults of an advanced teleost, the gray mullet (<i>Chelon labrosus</i>
). A different sequence of appearance was observed for expression of these proteins: Vim levels decreased with age, whereas GFAP increased. In general, both immunoreactivities were expressed early in perikarya and endfeet of ependymocytes (tanycytes), whereas expression in radial processes appeared later. In large larvae, the similar expression patterns of Vim and GFAP suggest that some of these glial cells contain both proteins. Subependymal radial glia cells were observed mainly in the optic tectum, exhibiting Vim and GFAP immunoreactivity. The only immunoreactive cells with astrocyte‐like morphology were observed in the optic chiasm of the adult, and they were positive for both GFAP and Vim. The perivascular processes of glial cells showed a different distribution of Vim and GFAP during development and had a caudorostral sequence of appearance of immunoreactivities similar to that observed for ependymal and radial glia cells. Several circumventricular organs (the organon vasculosum hypothalami, saccus vasculosus, and area postrema) exhibited highly specialized Vim‐ and/or GFAP‐expressing glial cells. The glial cells of the midline septa of several brain regions were also Vim and/or GFAP immunoreactive. In the adult brain, tanycytes retain Vim expression in several brain regions. As in other vertebrates, the regions with Vim‐immunoreactive ventricular and midline glia may represent areas with the capability of plasticity and regeneration in adult brain. J. Comp. Neurol. 469:413–436, 2004. © 2004 Wiley‐Liss, Inc.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost</title>
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<titleInfo type="abbreviated" lang="en"><title>Vimentin and GFAP in the Brain of a Teleost</title>
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<name type="personal"><namePart type="given">Mercedes</namePart>
<namePart type="family">Arochena</namePart>
<affiliation>Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruña, 15071‐A Coruña, Spain</affiliation>
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<name type="personal"><namePart type="given">Ramón</namePart>
<namePart type="family">Anadón</namePart>
<affiliation>Department of Fundamental Biology, University of Santiago de Compostela, 15706‐Santiago de Compostela, Spain</affiliation>
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<name type="personal"><namePart type="given">Sofía M.</namePart>
<namePart type="family">Díaz‐Regueira</namePart>
<affiliation>Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruña, 15071‐A Coruña, Spain</affiliation>
<affiliation>Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruña, 15071‐A Coruña, Spain</affiliation>
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<abstract lang="en">Previous studies in teleosts have revealed the presence of the intermediate filaments vimentin (Vim) and glial fibrillary acidic protein (GFAP) in glial cells of the spinal cord and/or some brain regions, but there is no comprehensive study of their distribution and developmental changes in fishes. Here, the distribution of Vim and GFAP immunoreactivities was studied in the brain of larvae, juveniles, and adults of an advanced teleost, the gray mullet (Chelon labrosus). A different sequence of appearance was observed for expression of these proteins: Vim levels decreased with age, whereas GFAP increased. In general, both immunoreactivities were expressed early in perikarya and endfeet of ependymocytes (tanycytes), whereas expression in radial processes appeared later. In large larvae, the similar expression patterns of Vim and GFAP suggest that some of these glial cells contain both proteins. Subependymal radial glia cells were observed mainly in the optic tectum, exhibiting Vim and GFAP immunoreactivity. The only immunoreactive cells with astrocyte‐like morphology were observed in the optic chiasm of the adult, and they were positive for both GFAP and Vim. The perivascular processes of glial cells showed a different distribution of Vim and GFAP during development and had a caudorostral sequence of appearance of immunoreactivities similar to that observed for ependymal and radial glia cells. Several circumventricular organs (the organon vasculosum hypothalami, saccus vasculosus, and area postrema) exhibited highly specialized Vim‐ and/or GFAP‐expressing glial cells. The glial cells of the midline septa of several brain regions were also Vim and/or GFAP immunoreactive. In the adult brain, tanycytes retain Vim expression in several brain regions. As in other vertebrates, the regions with Vim‐immunoreactive ventricular and midline glia may represent areas with the capability of plasticity and regeneration in adult brain. J. Comp. Neurol. 469:413–436, 2004. © 2004 Wiley‐Liss, Inc.</abstract>
<note type="funding">Spanish Science and Technology Ministry - No. BXX2000‐0453‐C02‐01; No. BXX2000‐0453‐C02‐01; </note>
<note type="funding">Xunta de Galicia - No. PGIDT99BIO20002; </note>
<subject lang="en"><genre>keywords</genre>
<topic>circumventricular organs</topic>
<topic>ependyma</topic>
<topic>immunocytochemistry</topic>
<topic>radial glia</topic>
<topic>tanycytes</topic>
<topic>teleosts</topic>
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<relatedItem type="host"><titleInfo><title>Journal of Comparative Neurology</title>
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<identifier type="ISSN">0021-9967</identifier>
<identifier type="eISSN">1096-9861</identifier>
<identifier type="DOI">10.1002/(ISSN)1096-9861</identifier>
<identifier type="PublisherID">CNE</identifier>
<part><date>2004</date>
<detail type="volume"><caption>vol.</caption>
<number>469</number>
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<detail type="issue"><caption>no.</caption>
<number>3</number>
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<extent unit="pages"><start>413</start>
<end>436</end>
<total>25</total>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 Wiley‐Liss, Inc.</accessCondition>
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