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Biomarkers and Their Potential Use in Transplantation

Identifieur interne : 001260 ( Istex/Corpus ); précédent : 001259; suivant : 001261

Biomarkers and Their Potential Use in Transplantation

Auteurs : Rafails Rozentals ; J Nis Jušinskis ; Diana Amerika

Source :

RBID : ISTEX:EDDC93F043E56F2BB2B96F216853F5EE0A643220

Abstract

The article presents an overview of literature related to two topical issues in modern medicine: transplantation and biomarkers. There have been advances made in the use of immunoenzymometric and immunoadsorption assays in organ transplantation clinics for evaluating different situations. However, these methods fail to solve more complex and ambiguous transplantation problems: tolerance, personification of treatment, etc. In this regard, the first results of prospective studies using OMICS methods of genomics and proteinomics, in relation to the notion of transplantomics, are presented

Url:
DOI: 10.2478/v10046-012-0013-0

Links to Exploration step

ISTEX:EDDC93F043E56F2BB2B96F216853F5EE0A643220

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<abstract lang="lv">Ir zināmi divi galvenie pēcoperācijas stresa sistēmiskie efekti: neiroendokrīnais un hematoimunoloģiskais efekts. Neiroendokrīnu atbildes reakciju inducē hipotalāma-hipofīzes-adrenālās sistēmas un simpato-adrenālās-medulārās sistēmas neironu aktivizācija. Hematoimunoloģisko atbildi raksturo citoklnu produkcija, akūtas fāzes reakcija, limfocltu un neitrofīlu leikocītu proliferācija. Visi sistēmiski efekti ir cieši saistīti un cits citu ietekmē. Pārāk izteikta stresa atbildes reakcija var novest pie palielinātas pēcoperācijas morbiditātes un pasliktināt operācijas iznākumu. Ķirurģisku stresu var ietekmēt preoperatīvi, perioperatīvi un postoperatīvi faktori. Rakstā apkopota literatūra par izmaiņām organismā, kuras notiek kā atbildes reakcija uz ķirurģisku stresu un apspriestas iespējamās stratēģijas, kā samazināt stresa atbildes reakciju un tās ietekmi uz organismu.</abstract>
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<genre>Keywords</genre>
<topic>organ transplantation</topic>
<topic>biomarkers</topic>
<topic>clinical and biochemical studies</topic>
<topic>immunoenzymometric and immunoabsorption methods</topic>
<topic>transplantomics</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences</title>
</titleInfo>
<genre type="journal">journal</genre>
<identifier type="ISSN">1407-009X</identifier>
<identifier type="PublisherID">prolas</identifier>
<part>
<date>2012</date>
<detail type="volume">
<caption>vol.</caption>
<number>66</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>6</number>
</detail>
<extent unit="pages">
<start>219</start>
<end>268</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">EDDC93F043E56F2BB2B96F216853F5EE0A643220</identifier>
<identifier type="DOI">10.2478/v10046-012-0013-0</identifier>
<identifier type="ArticleID">v10046-012-0013-0</identifier>
<identifier type="pdf">v10046-012-0013-0.pdf</identifier>
<accessCondition type="use and reproduction" contentType="open-access">This content is open access.</accessCondition>
<recordInfo>
<recordContentSource>De Gruyter</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>

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