Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function
Identifieur interne : 000F32 ( Istex/Corpus ); précédent : 000F31; suivant : 000F33Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function
Auteurs : E. Jirillo ; L. Passantino ; M. R. Ribaud ; G. F. PassantinoSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.
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DOI: 10.1111/j.1439-0264.2005.00669_51.x
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Jirillo</name><affiliation><mods:affiliation>Department of Internal Medicine, Immunology and Infectious Disease, Section of Microbiology and Immunology, Faculty of Medicine, University of Bari, Policlinico ‐Piazza G. Cesare‐ 70124 – Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Passantino, L" sort="Passantino, L" uniqKey="Passantino L" first="L." last="Passantino">L. Passantino</name><affiliation><mods:affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</mods:affiliation></affiliation></author><author><name sortKey="Ribaud, M R" sort="Ribaud, M R" uniqKey="Ribaud M" first="M. R." last="Ribaud">M. R. Ribaud</name><affiliation><mods:affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. 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Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Anatomia, Histologia, Embryologia</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="24">24</biblScope></imprint><idno type="ISSN">0340-2096</idno></series><idno type="istex">028F96085D75B34D3D8465B67D272BA7F9DBF4F7</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_51.x</idno><idno type="ArticleID">AHE669_51_51</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>E. 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Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function</title><author xml:id="author-1"><persName><forename type="first">E.</forename><surname>Jirillo</surname></persName><affiliation>Department of Internal Medicine, Immunology and Infectious Disease, Section of Microbiology and Immunology, Faculty of Medicine, University of Bari, Policlinico ‐Piazza G. Cesare‐ 70124 – Bari, Italy</affiliation></author><author xml:id="author-2"><persName><forename type="first">L.</forename><surname>Passantino</surname></persName><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation></author><author xml:id="author-3"><persName><forename type="first">M. R.</forename><surname>Ribaud</surname></persName><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation></author><author xml:id="author-4"><persName><forename type="first">G. F.</forename><surname>Passantino</surname></persName><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation></author></analytic><monogr><title level="j">Anatomia, Histologia, Embryologia</title><idno type="pISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><idno type="DOI">10.1111/(ISSN)1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12"></date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="24">24</biblScope></imprint></monogr><idno type="istex">028F96085D75B34D3D8465B67D272BA7F9DBF4F7</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_51.x</idno><idno type="ArticleID">AHE669_51_51</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.</p></abstract><abstract><p>References Passantino, L., M. Altamura, A. Cianciotta, R. Patruno, A. Tafaro, E. Jirillo, and Passantino G.F., 2002a: Fish immunology. I. Binding and engulfment of Candida albicans by erythrocytes of rainbow trout (Salmo gairdneri Richardson). Immunopharmacol. Immunotoxicol. 24: 665–678</p></abstract><abstract><p>Passantino, L., A. Tafaro, M. Altamura, R. Arena, G.F. Passantino, E. Jirillo, 2002b: Fish immunology. II. Morphological and cytochemical characterization and phagocytic activities of head kidney macrophages from rainbow trout (Salmo gairdneri Richardson). Immunopharmacol. Immunotoxicol.24: 679–691</p></abstract><abstract><p>Passantino, L., M. Altamura, A. Cianciotta, F. Jirillo, M.R. Ribaud, E. Jirillo, and G.F. Passantino, 2004: Maturation of fish erythrocytes coincides with changes in their morphology, enhanced ability to interact with Candida albicans and release of cytokine‐like factors active upon autologous macrophages. Immunopharmacol. Immunotoxicol. 26 (in press).</p></abstract></profileDesc><revisionDesc><change when="2005-12">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-13">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-02-8">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/028F96085D75B34D3D8465B67D272BA7F9DBF4F7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Verlag GmbH</publisherName><publisherLoc>Berlin, Germany</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0264</doi><issn type="print">0340-2096</issn><issn type="electronic">1439-0264</issn><idGroup><id type="product" value="AHE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANATOMIA HISTOLOGIA EMBRYOLOGIA">Anatomia, Histologia, Embryologia</title></titleGroup></publicationMeta><publicationMeta level="part" position="12000"><doi origin="wiley">10.1111/ahe.2005.34.issue-s1</doi><numberingGroup><numbering type="journalVolume" number="34">34</numbering><numbering type="supplement">s1</numbering></numberingGroup><coverDate startDate="2005-12">December 2005</coverDate></publicationMeta><publicationMeta level="unit" type="abstract" position="1" status="forIssue"><doi origin="wiley">10.1111/j.1439-0264.2005.00669_51.x</doi><idGroup><id type="unit" value="AHE669_51_51"></id></idGroup><titleGroup><title type="tocHeading1">Abstracts of the XXVth Congress of the European Association of Veterinary Anatomists (EAVA), Oslo, 28–31 July 2004</title></titleGroup><eventGroup><event type="firstOnline" date="2005-11-22"></event><event type="publishedOnlineFinalForm" date="2005-11-22"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:Header result:Header" date="2010-04-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="23">23</numbering><numbering type="pageLast" number="24">24</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:AHE.AHE669_51_51.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function</title><title type="short">Abstracts</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a51-1"><personName><givenNames>E.</givenNames><familyName>Jirillo</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a51-2"><personName><givenNames>L.</givenNames><familyName>Passantino</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a51-2"><personName><givenNames>M. R.</givenNames><familyName>Ribaud</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a51-2"><personName><givenNames>G. F.</givenNames><familyName>Passantino</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a51-1" countryCode="IT"><unparsedAffiliation>Department of Internal Medicine, Immunology and Infectious Disease, Section of Microbiology and Immunology, Faculty of Medicine, University of Bari, Policlinico ‐Piazza G. Cesare‐ 70124 – Bari, Italy</unparsedAffiliation></affiliation><affiliation xml:id="a51-2" countryCode="IT"><unparsedAffiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf <i>Candida albicans </i>(CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.</p><p><b>References </b> Passantino, L., M. Altamura, A. Cianciotta, R. Patruno, A. Tafaro, E. Jirillo, and Passantino G.F., 2002a: Fish immunology. I. Binding and engulfment of <i>Candida albicans </i>by erythrocytes of rainbow trout (<i>Salmo gairdneri </i>Richardson). Immunopharmacol. <i>Immunotoxicol.</i> 24: 665–678</p><p>Passantino, L., A. Tafaro, M. Altamura, R. Arena, G.F. Passantino, E. Jirillo, 2002b: Fish immunology. II. Morphological and cytochemical characterization and phagocytic activities of head kidney macrophages from rainbow trout (<i>Salmo gairdneri </i>Richardson). Immunopharmacol. <i>Immunotoxicol.</i>24: 679–691</p><p>Passantino, L., M. Altamura, A. Cianciotta, F. Jirillo, M.R. Ribaud, E. Jirillo, and G.F. Passantino, 2004: Maturation of fish erythrocytes coincides with changes in their morphology, enhanced ability to interact with <i>Candida albicans</i> and release of cytokine‐like factors active upon autologous macrophages. Immunopharmacol. Immunotoxicol. 26 (in press).</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Fish immunology. Fish Erythrocytes Release Cytokine‐like Factors that Modulate Autologous Macrophage Function</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Jirillo</namePart><affiliation>Department of Internal Medicine, Immunology and Infectious Disease, Section of Microbiology and Immunology, Faculty of Medicine, University of Bari, Policlinico ‐Piazza G. Cesare‐ 70124 – Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Passantino</namePart><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Ribaud</namePart><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. F.</namePart><namePart type="family">Passantino</namePart><affiliation>Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str. Prov.le per Casamassima Km 3, 70010, Valenzano (BA), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Verlag GmbH</publisher><place><placeTerm type="text">Berlin, Germany</placeTerm></place><dateIssued encoding="w3cdtf">2005-12</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>According to our previous findings (Passantino et al. 2002a,b; 2004) we discovered that fish erythrocytes (FE) act as immune cells in that they bind and engulf Candida albicans (CA). Then, these activated FE interact with macrophages (MØ) so that a so‐called rosette results from such an interplay. A rosette consists of one or more MØ containing ingested CA, centrally located and surrounded by CA activated FE. Quite interestingly, we found that supernatants of CA‐activated FE contain cytokine‐like factors able to modulate MØ function. In particular, active supernatants are able to inhibit MØ migration under agarose and this activity was identified as macrophage inhibiting factor (MIF) – like function, by analogy to human MIF. On the other hand, same supernatants could enhance MØ phagocytosis of CA, thus contributing to fungus killing. Taken together, these results suggest that FE act as immune cells by secreting cytokine‐like factors, which contribute to the rosette formation through modulation of MØ.</abstract><abstract>References Passantino, L., M. Altamura, A. Cianciotta, R. Patruno, A. Tafaro, E. Jirillo, and Passantino G.F., 2002a: Fish immunology. I. Binding and engulfment of Candida albicans by erythrocytes of rainbow trout (Salmo gairdneri Richardson). Immunopharmacol. Immunotoxicol. 24: 665–678</abstract><abstract>Passantino, L., A. Tafaro, M. Altamura, R. Arena, G.F. Passantino, E. Jirillo, 2002b: Fish immunology. II. Morphological and cytochemical characterization and phagocytic activities of head kidney macrophages from rainbow trout (Salmo gairdneri Richardson). Immunopharmacol. Immunotoxicol.24: 679–691</abstract><abstract>Passantino, L., M. Altamura, A. Cianciotta, F. Jirillo, M.R. Ribaud, E. Jirillo, and G.F. Passantino, 2004: Maturation of fish erythrocytes coincides with changes in their morphology, enhanced ability to interact with Candida albicans and release of cytokine‐like factors active upon autologous macrophages. Immunopharmacol. Immunotoxicol. 26 (in press).</abstract><relatedItem type="host"><titleInfo><title>Anatomia, Histologia, Embryologia</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0340-2096</identifier><identifier type="eISSN">1439-0264</identifier><identifier type="DOI">10.1111/(ISSN)1439-0264</identifier><identifier type="PublisherID">AHE</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>23</start><end>24</end></extent></part></relatedItem><identifier type="istex">028F96085D75B34D3D8465B67D272BA7F9DBF4F7</identifier><identifier type="DOI">10.1111/j.1439-0264.2005.00669_51.x</identifier><identifier type="ArticleID">AHE669_51_51</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Verlag GmbH</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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