Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Swiss Albino Mice. Proliferation and Expression of Pitx 2 and Calbindin D28K in Corticotropic and Somatotropic cell Differentiation
Identifieur interne : 000B68 ( Istex/Corpus ); précédent : 000B67; suivant : 000B69Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Swiss Albino Mice. Proliferation and Expression of Pitx 2 and Calbindin D28K in Corticotropic and Somatotropic cell Differentiation
Auteurs : R. Reyes ; S. Martínez ; M. González ; G. Tramu ; A. R. BelloSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2008-08.
Abstract
A developmental study of the adenohypophysis of the mouse was carried out in response to several as yet unanswered questions about its organogenesis and differentiation. The main objectives were to establish the origin of adenohypophysial lobes and cells from the Rathke’s pouch (RP) and elucidate the mechanisms of development and functional differentiation of the gland. Using diverse techniques, the morphological development, proliferation and differentiation were studied in order to delimit different proliferative regions in the RP, and provide a satisfactory explanation for the distribution of each cell type in the adult gland. Combining the proliferation and differentiation studies, corticotropic and somatotropic cells appear to mainly originate from undifferentiated precursors located within each of these proliferative regions. The involvement of transcription factor Pitx 2 and calcium‐binding protein Calbindin D 28K in the differentiation of corticotropic and somatotropic cells is further clarified.
Url:
DOI: 10.1111/j.1439-0264.2007.00839.x
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Martínez</name><affiliation><mods:affiliation>Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurosciences CSIC, University of Miguel Hernández, 03550 San Juan de Alicante, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez, M" sort="Gonzalez, M" uniqKey="Gonzalez M" first="M." last="González">M. González</name><affiliation><mods:affiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physiology, School of Medicine and Institute of Biomedical Technologies, University of La Laguna, Tenerife, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tramu, G" sort="Tramu, G" uniqKey="Tramu G" first="G." last="Tramu">G. Tramu</name><affiliation><mods:affiliation>Functional Neurocytochemistry Laboratory, EA 2972, Talence, France</mods:affiliation></affiliation></author><author><name sortKey="Bello, A R" sort="Bello, A R" uniqKey="Bello A" first="A. R." last="Bello">A. R. 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Martínez</name><affiliation><mods:affiliation>Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurosciences CSIC, University of Miguel Hernández, 03550 San Juan de Alicante, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez, M" sort="Gonzalez, M" uniqKey="Gonzalez M" first="M." last="González">M. González</name><affiliation><mods:affiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physiology, School of Medicine and Institute of Biomedical Technologies, University of La Laguna, Tenerife, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tramu, G" sort="Tramu, G" uniqKey="Tramu G" first="G." last="Tramu">G. 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Reyes</name><affiliations><json:string>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</json:string><json:string>*Corresponding author: Tel.: +34 22 31 84 17; fax: +34 22 31 83 11; e‐mail: rreyes7@hotmail.com</json:string></affiliations></json:item><json:item><name>S. Martínez</name><affiliations><json:string>Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</json:string><json:string>Institute of Neurosciences CSIC, University of Miguel Hernández, 03550 San Juan de Alicante, Spain</json:string></affiliations></json:item><json:item><name>M. 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The main objectives were to establish the origin of adenohypophysial lobes and cells from the Rathke’s pouch (RP) and elucidate the mechanisms of development and functional differentiation of the gland. Using diverse techniques, the morphological development, proliferation and differentiation were studied in order to delimit different proliferative regions in the RP, and provide a satisfactory explanation for the distribution of each cell type in the adult gland. Combining the proliferation and differentiation studies, corticotropic and somatotropic cells appear to mainly originate from undifferentiated precursors located within each of these proliferative regions. The involvement of transcription factor Pitx 2 and calcium‐binding protein Calbindin D 28K in the differentiation of corticotropic and somatotropic cells is further clarified.</p></abstract></profileDesc><revisionDesc><change when="2008-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9D7B02F8A4E0654E73C0FDAB8F55F79ED8C8D113/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0264</doi><issn type="print">0340-2096</issn><issn type="electronic">1439-0264</issn><idGroup><id type="product" value="AHE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANATOMIA HISTOLOGIA EMBRYOLOGIA">Anatomia, Histologia, Embryologia</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/ahe.2008.37.issue-4</doi><numberingGroup><numbering type="journalVolume" number="37">37</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2008-08">August 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1439-0264.2007.00839.x</doi><idGroup><id type="unit" value="AHE839"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><copyright>© 2008 The Authors. Journal compilation © 2008 Blackwell Verlag</copyright><eventGroup><event type="firstOnline" date="2008-01-23"></event><event type="publishedOnlineFinalForm" date="2008-07-15"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="263">263</numbering><numbering type="pageLast" number="271">271</numbering></numberingGroup><correspondenceTo>Cell Biology Section, School of Biology, University of La Laguna, Tenerife, Spain and Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AHE.AHE839.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received December 2006; accepted for publication July 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="7"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Swiss Albino Mice. Proliferation and Expression of <i>Pitx 2</i> and Calbindin D28K in Corticotropic and Somatotropic cell Differentiation</title><title type="shortAuthors">R. R<sc>eyes</sc> et al.</title><title type="short">Origin of Adenohypophysial Lobes and Cells in Mice</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a6" noteRef="#fn1"><personName><givenNames>R.</givenNames><familyName>Reyes</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3"><personName><givenNames>S.</givenNames><familyName>Martínez</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a5"><personName><givenNames>M.</givenNames><familyName>González</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>G.</givenNames><familyName>Tramu</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>A. R.</givenNames><familyName>Bello</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="ES"><unparsedAffiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ES"><unparsedAffiliation>Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="ES"><unparsedAffiliation>Institute of Neurosciences CSIC, University of Miguel Hernández, 03550 San Juan de Alicante, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>Functional Neurocytochemistry Laboratory, EA 2972, Talence, France</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="ES"><unparsedAffiliation>Department of Physiology, School of Medicine and Institute of Biomedical Technologies, University of La Laguna, Tenerife, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a6"><unparsedAffiliation>*Corresponding author: Tel.: +34 22 31 84 17; fax: +34 22 31 83 11; e‐mail: <email>rreyes7@hotmail.com</email></unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>A developmental study of the adenohypophysis of the mouse was carried out in response to several as yet unanswered questions about its organogenesis and differentiation. The main objectives were to establish the origin of adenohypophysial lobes and cells from the Rathke’s pouch (RP) and elucidate the mechanisms of development and functional differentiation of the gland. Using diverse techniques, the morphological development, proliferation and differentiation were studied in order to delimit different proliferative regions in the RP, and provide a satisfactory explanation for the distribution of each cell type in the adult gland. Combining the proliferation and differentiation studies, corticotropic and somatotropic cells appear to mainly originate from undifferentiated precursors located within each of these proliferative regions. The involvement of transcription factor <i>Pitx</i> 2 and calcium‐binding protein Calbindin D 28K in the differentiation of corticotropic and somatotropic cells is further clarified.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>†</label><p> Present address: Cell Metabolism Institute, C/Manuel de Falla 15, La Laguna 38208, Tenerife, Canary Islands, Spain.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Swiss Albino Mice. Proliferation and Expression of Pitx 2 and Calbindin D28K in Corticotropic and Somatotropic cell Differentiation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Origin of Adenohypophysial Lobes and Cells in Mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Origin of Adenohypophysial Lobes and Cells from Rathke’s Pouch in Swiss Albino Mice. Proliferation and Expression of Pitx 2 and Calbindin D28K in Corticotropic and Somatotropic cell Differentiation</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Reyes</namePart><affiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</affiliation><affiliation>*Corresponding author: Tel.: +34 22 31 84 17; fax: +34 22 31 83 11; e‐mail: rreyes7@hotmail.com</affiliation><description>Present address: Cell Metabolism Institute, C/Manuel de Falla 15, La Laguna 38208, Tenerife, Canary Islands, Spain.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Martínez</namePart><affiliation>Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, Spain</affiliation><affiliation>Institute of Neurosciences CSIC, University of Miguel Hernández, 03550 San Juan de Alicante, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">González</namePart><affiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</affiliation><affiliation>Department of Physiology, School of Medicine and Institute of Biomedical Technologies, University of La Laguna, Tenerife, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Tramu</namePart><affiliation>Functional Neurocytochemistry Laboratory, EA 2972, Talence, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. R.</namePart><namePart type="family">Bello</namePart><affiliation>Addresses of authors: Cell Biology Section, School of Biology, University of La Laguna, 38206 Tenerife, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-08</dateIssued><edition>Received December 2006; accepted for publication July 2007</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">7</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">A developmental study of the adenohypophysis of the mouse was carried out in response to several as yet unanswered questions about its organogenesis and differentiation. The main objectives were to establish the origin of adenohypophysial lobes and cells from the Rathke’s pouch (RP) and elucidate the mechanisms of development and functional differentiation of the gland. Using diverse techniques, the morphological development, proliferation and differentiation were studied in order to delimit different proliferative regions in the RP, and provide a satisfactory explanation for the distribution of each cell type in the adult gland. Combining the proliferation and differentiation studies, corticotropic and somatotropic cells appear to mainly originate from undifferentiated precursors located within each of these proliferative regions. The involvement of transcription factor Pitx 2 and calcium‐binding protein Calbindin D 28K in the differentiation of corticotropic and somatotropic cells is further clarified.</abstract><relatedItem type="host"><titleInfo><title>Anatomia, Histologia, Embryologia</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0340-2096</identifier><identifier type="eISSN">1439-0264</identifier><identifier type="DOI">10.1111/(ISSN)1439-0264</identifier><identifier type="PublisherID">AHE</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>263</start><end>271</end><total>9</total></extent></part></relatedItem><identifier type="istex">9D7B02F8A4E0654E73C0FDAB8F55F79ED8C8D113</identifier><identifier type="DOI">10.1111/j.1439-0264.2007.00839.x</identifier><identifier type="ArticleID">AHE839</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Authors. 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