Guppy Sexual Behavior as an Effect Biomarker of Estrogen Mimics
Identifieur interne : 000B42 ( Istex/Corpus ); précédent : 000B41; suivant : 000B43Guppy Sexual Behavior as an Effect Biomarker of Estrogen Mimics
Auteurs : Mark Bayley ; Jacob R. Nielsen ; Erik BaatrupSource :
- Ecotoxicology and Environmental Safety [ 0147-6513 ] ; 1999.
English descriptors
Abstract
There is widespread concern that some environmental chemicals can reduce the reproductive capability of humans and wildlife by mimicking natural estrogens and disrupting endocrine function. This potential threat to animal populations posed by xenoestrogens has, hardly surprisingly, been met by an intensive global effort to identify and develop biomarkers suitable for screening chemicals for estrogen mimicking capacity. Despite this effort, there are few biomarkers capable of linking exposure to xenoestrogens to impaired reproductive capability. The reproductive success of most animals depends strongly on the ability to perform the appropriate sexual behavior. The sexual display of the male guppy is strongly linked to reproductive success and is readily quantified under laboratory conditions. This preliminary study demonstrates that exposure of adult male guppies to water weakly contaminated with either natural estrogen (17β-estradiol) or the xenoestrogen (4-tert-octylphenol) causes a dramatic decrease in the rate and intensity of sexual display. It is concluded that quantitative analysis of the sexual display of male guppies holds great promise as a biomarker at the organismal level for the effects of estrogen mimicking xenobiotics.
Url:
DOI: 10.1006/eesa.1999.1766
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ISTEX:F6D95760B13CA8E0AA21EB7D442DFE59C173E314Le document en format XML
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R. KrebsT. Clutton-Brock</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Guppy Sexual Behavior as an Effect Biomarker of Estrogen Mimics</ce:title><ce:author-group><ce:author><ce:given-name>Mark</ce:given-name><ce:surname>Bayley</ce:surname></ce:author><ce:author><ce:given-name>Jacob R.</ce:given-name><ce:surname>Nielsen</ce:surname></ce:author><ce:author><ce:given-name>Erik</ce:given-name><ce:surname>Baatrup</ce:surname><ce:cross-ref refid="QFN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Institute of Biological Sciences, University of Aarhus, Building 135, DK-8000, Aarhus, Denmark</ce:textfn></ce:affiliation><ce:footnote id="QFN1"><ce:label>1</ce:label><ce:note-para>To whom correspondence should be addressed. Fax: +45 8612 5175.E-mail: Erik.Baatrup@biology.aau.dk.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="6" month="4" year="1998"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>There is widespread concern that some environmental chemicals can reduce the reproductive capability of humans and wildlife by mimicking natural estrogens and disrupting endocrine function. This potential threat to animal populations posed by xenoestrogens has, hardly surprisingly, been met by an intensive global effort to identify and develop biomarkers suitable for screening chemicals for estrogen mimicking capacity. Despite this effort, there are few biomarkers capable of linking exposure to xenoestrogens to impaired reproductive capability. The reproductive success of most animals depends strongly on the ability to perform the appropriate sexual behavior. 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Fax: +45 8612 5175.E-mail: Erik.Baatrup@biology.aau.dk.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">There is widespread concern that some environmental chemicals can reduce the reproductive capability of humans and wildlife by mimicking natural estrogens and disrupting endocrine function. This potential threat to animal populations posed by xenoestrogens has, hardly surprisingly, been met by an intensive global effort to identify and develop biomarkers suitable for screening chemicals for estrogen mimicking capacity. Despite this effort, there are few biomarkers capable of linking exposure to xenoestrogens to impaired reproductive capability. The reproductive success of most animals depends strongly on the ability to perform the appropriate sexual behavior. The sexual display of the male guppy is strongly linked to reproductive success and is readily quantified under laboratory conditions. This preliminary study demonstrates that exposure of adult male guppies to water weakly contaminated with either natural estrogen (17β-estradiol) or the xenoestrogen (4-tert-octylphenol) causes a dramatic decrease in the rate and intensity of sexual display. It is concluded that quantitative analysis of the sexual display of male guppies holds great promise as a biomarker at the organismal level for the effects of estrogen mimicking xenobiotics.</abstract><note>J. R. KrebsT. Clutton-Brock</note><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>xenoestrogen</topic><topic>guppy sexual behavior</topic><topic>biomarker</topic><topic>reproduction</topic><topic>Poecilia reticulata.</topic></subject><relatedItem type="host"><titleInfo><title>Ecotoxicology and Environmental Safety</title></titleInfo><titleInfo type="abbreviated"><title>YEESA</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199905</dateIssued></originInfo><identifier type="ISSN">0147-6513</identifier><identifier type="PII">S0147-6513(00)X0026-7</identifier><part><date>199905</date><detail type="volume"><number>43</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>116</end></extent><extent unit="pages"><start>68</start><end>73</end></extent></part></relatedItem><identifier type="istex">F6D95760B13CA8E0AA21EB7D442DFE59C173E314</identifier><identifier type="DOI">10.1006/eesa.1999.1766</identifier><identifier type="PII">S0147-6513(99)91766-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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