Investigation of Senescence in Canine Fibroblasts
Identifieur interne : 000998 ( Istex/Corpus ); précédent : 000997; suivant : 000999Investigation of Senescence in Canine Fibroblasts
Auteurs : S. Streit ; F. Salomon ; T. StahlSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
Introduction and Aims: Primary and secondary cell cultures of canine dermal fibroblasts were used to test the suitability of several senescence‐linked cellular markers to characterize the chronological age of dogs. In further studies these markers will be used to test the hypothesis that senescence‐linked changes at the cellular level are representative for the observed inverse relationship of body mass and life expectancy in different dog breeds.
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DOI: 10.1111/j.1439-0264.2005.00669_115.x
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Stahl</name><affiliation><mods:affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4D4F2BA87C60605EEE1F64C4029E6913CE255BB</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1439-0264.2005.00669_115.x</idno><idno type="url">https://api.istex.fr/document/E4D4F2BA87C60605EEE1F64C4029E6913CE255BB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000998</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000998</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Investigation of Senescence in Canine Fibroblasts</title><author><name sortKey="Streit, S" sort="Streit, S" uniqKey="Streit S" first="S." last="Streit">S. Streit</name><affiliation><mods:affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Salomon, F" sort="Salomon, F" uniqKey="Salomon F" first="F." last="Salomon">F. Salomon</name><affiliation><mods:affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stahl, T" sort="Stahl, T" uniqKey="Stahl T" first="T." last="Stahl">T. Stahl</name><affiliation><mods:affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Anatomia, Histologia, Embryologia</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="51">51</biblScope></imprint><idno type="ISSN">0340-2096</idno></series><idno type="istex">E4D4F2BA87C60605EEE1F64C4029E6913CE255BB</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_115.x</idno><idno type="ArticleID">AHE669_115_115</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Introduction and Aims: Primary and secondary cell cultures of canine dermal fibroblasts were used to test the suitability of several senescence‐linked cellular markers to characterize the chronological age of dogs. In further studies these markers will be used to test the hypothesis that senescence‐linked changes at the cellular level are representative for the observed inverse relationship of body mass and life expectancy in different dog breeds.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. Streit</name><affiliations><json:string>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</json:string></affiliations></json:item><json:item><name>F. ‐V. Salomon</name><affiliations><json:string>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</json:string></affiliations></json:item><json:item><name>T. Stahl</name><affiliations><json:string>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</json:string></affiliations></json:item></author><articleId><json:string>AHE669_115_115</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><qualityIndicators><score>6.292</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>452</abstractCharCount><pdfWordCount>39539</pdfWordCount><pdfCharCount>256516</pdfCharCount><pdfPageCount>59</pdfPageCount><abstractWordCount>66</abstractWordCount></qualityIndicators><title>Investigation of Senescence in Canine Fibroblasts</title><genre><json:string>abstract</json:string></genre><host><volume>34</volume><publisherId><json:string>AHE</json:string></publisherId><pages><last>51</last><first>50</first></pages><issn><json:string>0340-2096</json:string></issn><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1439-0264</json:string></eissn><title>Anatomia, Histologia, Embryologia</title><doi><json:string>10.1111/(ISSN)1439-0264</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>veterinary sciences</json:string><json:string>anatomy & morphology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>developmental biology</json:string></scienceMetrix></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1111/j.1439-0264.2005.00669_115.x</json:string></doi><id>E4D4F2BA87C60605EEE1F64C4029E6913CE255BB</id><score>0.02464886</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/E4D4F2BA87C60605EEE1F64C4029E6913CE255BB/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/E4D4F2BA87C60605EEE1F64C4029E6913CE255BB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E4D4F2BA87C60605EEE1F64C4029E6913CE255BB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Investigation of Senescence in Canine Fibroblasts</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><availability><p>WILEY</p></availability><date>2005</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Investigation of Senescence in Canine Fibroblasts</title><author xml:id="author-1"><persName><forename type="first">S.</forename><surname>Streit</surname></persName><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">F. ‐V.</forename><surname>Salomon</surname></persName><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">T.</forename><surname>Stahl</surname></persName><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation></author></analytic><monogr><title level="j">Anatomia, Histologia, Embryologia</title><idno type="pISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><idno type="DOI">10.1111/(ISSN)1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12"></date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="51">51</biblScope></imprint></monogr><idno type="istex">E4D4F2BA87C60605EEE1F64C4029E6913CE255BB</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_115.x</idno><idno type="ArticleID">AHE669_115_115</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Introduction and Aims: Primary and secondary cell cultures of canine dermal fibroblasts were used to test the suitability of several senescence‐linked cellular markers to characterize the chronological age of dogs. In further studies these markers will be used to test the hypothesis that senescence‐linked changes at the cellular level are representative for the observed inverse relationship of body mass and life expectancy in different dog breeds.</p></abstract><abstract><p>Methods: In this study standardized skin samples of Beagles were used to analyse the cell morphology and several senescence‐linked parameters as Cumulative Population Doubling Level, Highest Population Doubling Level, Culture Doubling Time and Life Span Completed to determine the replicative potential of fibroblasts. The samples were divided by the age of the donors into three groups (‘young’, ‘middle’ and ‘old’).</p></abstract><abstract><p>Results: There are notable differences between the replicative potential of young and old Beagles at the cellular level. Preliminary results show that in fibroblast cultures obtained from the young group the highest population doubling level is higher and the culture doubling time is shorter then in cultures of the old group. Cultures from the young and middle‐aged group cannot be distinguished by the measured parameters. For final results the complete statistical analysis of sampled data has to be carried out.</p></abstract><abstract><p>Conclusions: Our results demonstrate a relationship between the chronological age of the skin donor and the replicative potential of the dermal fibroblasts. 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In further studies these markers will be used to test the hypothesis that senescence‐linked changes at the cellular level are representative for the observed inverse relationship of body mass and life expectancy in different dog breeds.</p><p><b>Methods: </b> In this study standardized skin samples of Beagles were used to analyse the cell morphology and several senescence‐linked parameters as Cumulative Population Doubling Level, Highest Population Doubling Level, Culture Doubling Time and Life Span Completed to determine the replicative potential of fibroblasts. The samples were divided by the age of the donors into three groups (‘young’, ‘middle’ and ‘old’).</p><p><b>Results: </b> There are notable differences between the replicative potential of young and old Beagles at the cellular level. Preliminary results show that in fibroblast cultures obtained from the young group the highest population doubling level is higher and the culture doubling time is shorter then in cultures of the old group. Cultures from the young and middle‐aged group cannot be distinguished by the measured parameters. For final results the complete statistical analysis of sampled data has to be carried out.</p><p><b>Conclusions: </b> Our results demonstrate a relationship between the chronological age of the skin donor and the replicative potential of the dermal fibroblasts. Therefore cellular senescence‐linked markers could serve as suitable tools to compare the age of individual dogs of different breeds.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Investigation of Senescence in Canine Fibroblasts</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Investigation of Senescence in Canine Fibroblasts</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Streit</namePart><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. ‐V.</namePart><namePart type="family">Salomon</namePart><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Stahl</namePart><affiliation>Veterinär‐Anatomisches Institut der Universität Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Verlag GmbH</publisher><place><placeTerm type="text">Berlin, Germany</placeTerm></place><dateIssued encoding="w3cdtf">2005-12</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Introduction and Aims: Primary and secondary cell cultures of canine dermal fibroblasts were used to test the suitability of several senescence‐linked cellular markers to characterize the chronological age of dogs. In further studies these markers will be used to test the hypothesis that senescence‐linked changes at the cellular level are representative for the observed inverse relationship of body mass and life expectancy in different dog breeds.</abstract><abstract>Methods: In this study standardized skin samples of Beagles were used to analyse the cell morphology and several senescence‐linked parameters as Cumulative Population Doubling Level, Highest Population Doubling Level, Culture Doubling Time and Life Span Completed to determine the replicative potential of fibroblasts. The samples were divided by the age of the donors into three groups (‘young’, ‘middle’ and ‘old’).</abstract><abstract>Results: There are notable differences between the replicative potential of young and old Beagles at the cellular level. Preliminary results show that in fibroblast cultures obtained from the young group the highest population doubling level is higher and the culture doubling time is shorter then in cultures of the old group. Cultures from the young and middle‐aged group cannot be distinguished by the measured parameters. For final results the complete statistical analysis of sampled data has to be carried out.</abstract><abstract>Conclusions: Our results demonstrate a relationship between the chronological age of the skin donor and the replicative potential of the dermal fibroblasts. Therefore cellular senescence‐linked markers could serve as suitable tools to compare the age of individual dogs of different breeds.</abstract><relatedItem type="host"><titleInfo><title>Anatomia, Histologia, Embryologia</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0340-2096</identifier><identifier type="eISSN">1439-0264</identifier><identifier type="DOI">10.1111/(ISSN)1439-0264</identifier><identifier type="PublisherID">AHE</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>50</start><end>51</end></extent></part></relatedItem><identifier type="istex">E4D4F2BA87C60605EEE1F64C4029E6913CE255BB</identifier><identifier type="DOI">10.1111/j.1439-0264.2005.00669_115.x</identifier><identifier type="ArticleID">AHE669_115_115</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Verlag GmbH</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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