Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic
Identifieur interne : 000338 ( Istex/Corpus ); précédent : 000337; suivant : 000339Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic
Auteurs : José María Navas ; Eduardo González-Mazo ; Andrea Wenzel ; Abelardo G Mez-Parra ; Helmut SegnerSource :
- Marine Pollution Bulletin [ 0025-326X ] ; 1999.
Abstract
A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two in vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.
Url:
DOI: 10.1016/S0025-326X(99)00036-3
Links to Exploration step
ISTEX:254A9D2BED39378A38B70D8F7E9633D222E86552Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title><author><name sortKey="Navas, Jose Maria" sort="Navas, Jose Maria" uniqKey="Navas J" first="José María" last="Navas">José María Navas</name><affiliation><mods:affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jn@theo.uoe.ufz.de</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez Mazo, Eduardo" sort="Gonzalez Mazo, Eduardo" uniqKey="Gonzalez Mazo E" first="Eduardo" last="González-Mazo">Eduardo González-Mazo</name><affiliation><mods:affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</mods:affiliation></affiliation></author><author><name sortKey="Wenzel, Andrea" sort="Wenzel, Andrea" uniqKey="Wenzel A" first="Andrea" last="Wenzel">Andrea Wenzel</name><affiliation><mods:affiliation>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="G Mez Parra, Abelardo" sort="G Mez Parra, Abelardo" uniqKey="G Mez Parra A" first="Abelardo" last="G Mez-Parra">Abelardo G Mez-Parra</name><affiliation><mods:affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</mods:affiliation></affiliation></author><author><name sortKey="Segner, Helmut" sort="Segner, Helmut" uniqKey="Segner H" first="Helmut" last="Segner">Helmut Segner</name><affiliation><mods:affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:254A9D2BED39378A38B70D8F7E9633D222E86552</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0025-326X(99)00036-3</idno><idno type="url">https://api.istex.fr/document/254A9D2BED39378A38B70D8F7E9633D222E86552/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000338</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000338</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title><author><name sortKey="Navas, Jose Maria" sort="Navas, Jose Maria" uniqKey="Navas J" first="José María" last="Navas">José María Navas</name><affiliation><mods:affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jn@theo.uoe.ufz.de</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez Mazo, Eduardo" sort="Gonzalez Mazo, Eduardo" uniqKey="Gonzalez Mazo E" first="Eduardo" last="González-Mazo">Eduardo González-Mazo</name><affiliation><mods:affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</mods:affiliation></affiliation></author><author><name sortKey="Wenzel, Andrea" sort="Wenzel, Andrea" uniqKey="Wenzel A" first="Andrea" last="Wenzel">Andrea Wenzel</name><affiliation><mods:affiliation>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="G Mez Parra, Abelardo" sort="G Mez Parra, Abelardo" uniqKey="G Mez Parra A" first="Abelardo" last="G Mez-Parra">Abelardo G Mez-Parra</name><affiliation><mods:affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</mods:affiliation></affiliation></author><author><name sortKey="Segner, Helmut" sort="Segner, Helmut" uniqKey="Segner H" first="Helmut" last="Segner">Helmut Segner</name><affiliation><mods:affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Marine Pollution Bulletin</title><title level="j" type="abbrev">MPB</title><idno type="ISSN">0025-326X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="880">880</biblScope><biblScope unit="page" to="884">884</biblScope></imprint><idno type="ISSN">0025-326X</idno></series><idno type="istex">254A9D2BED39378A38B70D8F7E9633D222E86552</idno><idno type="DOI">10.1016/S0025-326X(99)00036-3</idno><idno type="PII">S0025-326X(99)00036-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0025-326X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two in vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>JosÉ MarÍa Navas</name><affiliations><json:string>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</json:string><json:string>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</json:string><json:string>E-mail: jn@theo.uoe.ufz.de</json:string></affiliations></json:item><json:item><name>Eduardo GonzÁlez-Mazo</name><affiliations><json:string>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</json:string></affiliations></json:item><json:item><name>Andrea Wenzel</name><affiliations><json:string>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</json:string></affiliations></json:item><json:item><name>Abelardo GÓmez-Parra</name><affiliations><json:string>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</json:string></affiliations></json:item><json:item><name>Helmut Segner</name><affiliations><json:string>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Linear alkylbenzene sulfonates</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sulfophenyl carboxylates</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Xenoestrogens</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rainbow trout hepatocytes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Estrogen receptor</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two in vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.</abstract><qualityIndicators><score>4.234</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>828</abstractCharCount><pdfWordCount>2854</pdfWordCount><pdfCharCount>17779</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>115</abstractWordCount></qualityIndicators><title>Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title><pii><json:string>S0025-326X(99)00036-3</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>38</volume><pii><json:string>S0025-326X(00)X0064-1</json:string></pii><pages><last>884</last><first>880</first></pages><issn><json:string>0025-326X</json:string></issn><issue>10</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Marine Pollution Bulletin</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>science</json:string><json:string>marine & freshwater biology</json:string><json:string>environmental sciences</json:string></wos><scienceMetrix><json:string>natural sciences</json:string><json:string>biology</json:string><json:string>marine biology & hydrobiology</json:string></scienceMetrix></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0025-326X(99)00036-3</json:string></doi><id>254A9D2BED39378A38B70D8F7E9633D222E86552</id><score>0.039099935</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/254A9D2BED39378A38B70D8F7E9633D222E86552/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/254A9D2BED39378A38B70D8F7E9633D222E86552/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/254A9D2BED39378A38B70D8F7E9633D222E86552/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1999 Elsevier Science Ltd</p></availability><date>1999</date></publicationStmt><notesStmt><note type="content">Fig. 1: Vitellogenin levels (μg−1/g protein) observed in controls, and in the cells treated with 1 μM E2 and with the different concentrations (μM values indicated in the x-axis) of LAS (Linear Alkylbenzene Sulfonate), SPC5, and SPC11 (Sulfophenyl Carboxylate C5 and C11). Data are expressed as mean±SEM (n=4 fishes).</note><note type="content">Fig. 2: Percent of LDH leakage from the control cells and from the cells treated with 1 μM E2 and with the different concentrations (μM values indicated in the x-axis) of LAS (Linear Alkylbenzene Sulfonate), SPC5, and SPC11 (Sulfophenyl Carboxylate C5 and C11). Data are expressed as mean±SEM (n=3 fishes).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title><author xml:id="author-1"><persName><forename type="first">JosÉ MarÍa</forename><surname>Navas</surname></persName><email>jn@theo.uoe.ufz.de</email><affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</affiliation><affiliation>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</affiliation></author><author xml:id="author-2"><persName><forename type="first">Eduardo</forename><surname>GonzÁlez-Mazo</surname></persName><affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</affiliation></author><author xml:id="author-3"><persName><forename type="first">Andrea</forename><surname>Wenzel</surname></persName><affiliation>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">Abelardo</forename><surname>GÓmez-Parra</surname></persName><affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</affiliation></author><author xml:id="author-5"><persName><forename type="first">Helmut</forename><surname>Segner</surname></persName><affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</affiliation></author></analytic><monogr><title level="j">Marine Pollution Bulletin</title><title level="j" type="abbrev">MPB</title><idno type="pISSN">0025-326X</idno><idno type="PII">S0025-326X(00)X0064-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">38</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="880">880</biblScope><biblScope unit="page" to="884">884</biblScope></imprint></monogr><idno type="istex">254A9D2BED39378A38B70D8F7E9633D222E86552</idno><idno type="DOI">10.1016/S0025-326X(99)00036-3</idno><idno type="PII">S0025-326X(99)00036-3</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two in vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Linear alkylbenzene sulfonates</term></item><item><term>Sulfophenyl carboxylates</term></item><item><term>Xenoestrogens</term></item><item><term>Rainbow trout hepatocytes</term></item><item><term>Estrogen receptor</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/254A9D2BED39378A38B70D8F7E9633D222E86552/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>MPB</jid><aid>1190</aid><ce:pii>S0025-326X(99)00036-3</ce:pii><ce:doi>10.1016/S0025-326X(99)00036-3</ce:doi><ce:copyright type="full-transfer" year="1999">Elsevier Science Ltd</ce:copyright></item-info><head><ce:title>Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</ce:title><ce:author-group><ce:author><ce:given-name>JosÉ MarÍa</ce:given-name><ce:surname>Navas</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>jn@theo.uoe.ufz.de</ce:e-address></ce:author><ce:author><ce:given-name>Eduardo</ce:given-name><ce:surname>GonzÁlez-Mazo</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Andrea</ce:given-name><ce:surname>Wenzel</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Abelardo</ce:given-name><ce:surname>GÓmez-Parra</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Helmut</ce:given-name><ce:surname>Segner</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two <ce:italic>in vitro</ce:italic> assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Linear alkylbenzene sulfonates</ce:text></ce:keyword><ce:keyword><ce:text>Sulfophenyl carboxylates</ce:text></ce:keyword><ce:keyword><ce:text>Xenoestrogens</ce:text></ce:keyword><ce:keyword><ce:text>Rainbow trout hepatocytes</ce:text></ce:keyword><ce:keyword><ce:text>Estrogen receptor</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic</title></titleInfo><name type="personal"><namePart type="given">JosÉ MarÍa</namePart><namePart type="family">Navas</namePart><affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</affiliation><affiliation>Corresponding author. Tel.: +49-341-235-2272; fax: +49-341-235-2401</affiliation><affiliation>E-mail: jn@theo.uoe.ufz.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">GonzÁlez-Mazo</namePart><affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrea</namePart><namePart type="family">Wenzel</namePart><affiliation>Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Auf dem Aberg 1, D-57392 Schmallenberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Abelardo</namePart><namePart type="family">GÓmez-Parra</namePart><affiliation>Departamento de Quı́mica Fı́sica, Facultad de Ciencias del Mar, Universidad de Cádiz, Campus Rı́o San Pedro s/n, 11510 Puerto Real, Cádiz, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helmut</namePart><namePart type="family">Segner</namePart><affiliation>Umweltforschungszentrum Leipzig-Halle GmbH, Chemische Ökotoxikologie, Permoserstr 15, D-04318 Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates. Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cádiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects. The present work addresses the question upon the possible estrogenicity of LAS and LAS metabolites by two in vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes. With both bioassays no estrogenic effects were observed for any of the compounds tested.</abstract><note type="content">Fig. 1: Vitellogenin levels (μg−1/g protein) observed in controls, and in the cells treated with 1 μM E2 and with the different concentrations (μM values indicated in the x-axis) of LAS (Linear Alkylbenzene Sulfonate), SPC5, and SPC11 (Sulfophenyl Carboxylate C5 and C11). Data are expressed as mean±SEM (n=4 fishes).</note><note type="content">Fig. 2: Percent of LDH leakage from the control cells and from the cells treated with 1 μM E2 and with the different concentrations (μM values indicated in the x-axis) of LAS (Linear Alkylbenzene Sulfonate), SPC5, and SPC11 (Sulfophenyl Carboxylate C5 and C11). Data are expressed as mean±SEM (n=3 fishes).</note><subject><genre>Keywords</genre><topic>Linear alkylbenzene sulfonates</topic><topic>Sulfophenyl carboxylates</topic><topic>Xenoestrogens</topic><topic>Rainbow trout hepatocytes</topic><topic>Estrogen receptor</topic></subject><relatedItem type="host"><titleInfo><title>Marine Pollution Bulletin</title></titleInfo><titleInfo type="abbreviated"><title>MPB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199910</dateIssued></originInfo><identifier type="ISSN">0025-326X</identifier><identifier type="PII">S0025-326X(00)X0064-1</identifier><part><date>199910</date><detail type="volume"><number>38</number><caption>vol.</caption></detail><detail type="issue"><number>10</number><caption>no.</caption></detail><extent unit="issue pages"><start>845</start><end>947</end></extent><extent unit="pages"><start>880</start><end>884</end></extent></part></relatedItem><identifier type="istex">254A9D2BED39378A38B70D8F7E9633D222E86552</identifier><identifier type="DOI">10.1016/S0025-326X(99)00036-3</identifier><identifier type="PII">S0025-326X(99)00036-3</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 Elsevier Science Ltd</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Ltd, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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