Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys.
Identifieur interne : 000F02 ( Main/Exploration ); précédent : 000F01; suivant : 000F03Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys.
Auteurs : Cynthia G. Fowler [États-Unis] ; Kirstin Beach Chiasson [États-Unis] ; Ricki J. Colman [États-Unis] ; Joseph W. Kemnitz [États-Unis] ; T Mark Beasley [États-Unis] ; Richard H. Weindruch [États-Unis]Source :
- Hearing research [ 1878-5891 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cochlée (physiologie), Complications du diabète (MeSH), Diabète de type 2 (complications), Diabète de type 2 (physiopathologie), Facteurs de risque (MeSH), Femelle (MeSH), Glycémie (analyse), Hyperinsulinisme (complications), Hyperinsulinisme (physiopathologie), Indice de masse corporelle (MeSH), Macaca mulatta (MeSH), Mode de vie (MeSH), Modèles animaux (MeSH), Mâle (MeSH), Ouïe (MeSH), Perte d'audition (complications), Potentiels évoqués auditifs du tronc cérébral (physiologie), Rapport signal-bruit (MeSH), Reproductibilité des résultats (MeSH), Restriction calorique (MeSH), Seuil auditif (physiologie), Vieillissement (MeSH), Émissions otoacoustiques spontanées (physiologie), État prédiabétique (complications), Études rétrospectives (MeSH).
- MESH :
- analyse : Glycémie.
- physiologie : Cochlée, Potentiels évoqués auditifs du tronc cérébral, Seuil auditif, Émissions otoacoustiques spontanées.
- physiopathologie : Diabète de type 2, Hyperinsulinisme.
- complications : Animaux, Complications du diabète, Diabète de type 2, Facteurs de risque, Femelle, Hyperinsulinisme, Indice de masse corporelle, Macaca mulatta, Mode de vie, Modèles animaux, Mâle, Ouïe, Perte d'audition, Rapport signal-bruit, Reproductibilité des résultats, Restriction calorique, Vieillissement, État prédiabétique, Études rétrospectives.
English descriptors
- KwdEn :
- Aging (MeSH), Animals (MeSH), Auditory Threshold (physiology), Blood Glucose (analysis), Body Mass Index (MeSH), Caloric Restriction (MeSH), Cochlea (physiology), Diabetes Complications (MeSH), Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (physiopathology), Evoked Potentials, Auditory, Brain Stem (physiology), Female (MeSH), Hearing (MeSH), Hearing Loss (complications), Hyperinsulinism (complications), Hyperinsulinism (physiopathology), Life Style (MeSH), Macaca mulatta (MeSH), Male (MeSH), Models, Animal (MeSH), Otoacoustic Emissions, Spontaneous (physiology), Prediabetic State (complications), Reproducibility of Results (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Signal-To-Noise Ratio (MeSH).
- MESH :
- chemical , analysis : Blood Glucose.
- complications : Diabetes Mellitus, Type 2, Hearing Loss, Hyperinsulinism, Prediabetic State.
- physiology : Auditory Threshold, Cochlea, Evoked Potentials, Auditory, Brain Stem, Otoacoustic Emissions, Spontaneous.
- physiopathology : Diabetes Mellitus, Type 2, Hyperinsulinism.
- Aging, Animals, Body Mass Index, Caloric Restriction, Diabetes Complications, Female, Hearing, Life Style, Macaca mulatta, Male, Models, Animal, Reproducibility of Results, Retrospective Studies, Risk Factors, Signal-To-Noise Ratio.
Abstract
The purpose of this study was to determine the effects of hyperinsulinemia/Type 2 diabetes mellitus (HI-T2DM) on hearing impairment using rhesus monkeys to obtain control over diet and lifestyle factors that confound human studies. The study is a retrospective evaluation of rhesus monkeys from the Wisconsin National Primate Research Center (WNPRC) study on caloric restriction and aging. The research questions were the following: 1. Is HI-T2DM related to hearing impairment? 2. If so, what is the site of lesion in the auditory system? and 3. What physiological factors affect the risk of hearing loss in HI-T2DM? Three groups of eight monkeys each were matched by sex and age; the caloric restricted (CR) monkeys had a reduced risk of diabetes, the normal control (NL) group had a normal risk, and the hyperinsulinemia/diabetes (HI-D) group had already developed HI-T2DM. Auditory testing included distortion product otoacoustic emissions (DPOAEs) with f2 frequencies from 2211 to 8837 Hz and auditory brainstem responses (ABRs) obtained with clicks and tone bursts (8, 16, and 32 kHz). DPOAEs had signal-to-noise ratios 8-17 dB larger in the NL group than in the HI-D and CR groups, signifying that cochlear function was best in the NL group. ABR thresholds were 5-8 dB better in the NL group than in the HI-D group, although no significant differences across the groups were evident for the thresholds, latencies, interwave intervals, or amplitudes. Correlations were significant for quadratic relations between body mass index (BMI) and DPOAE, with largest DPOAEs for animals in the middle of the BMI range. ABR thresholds elicited with 16 and 32 kHz signals were significantly correlated, positively with BMI and HbA1c, and negatively with KG (glucose tolerance), SI (insulin sensitivity index) and DI (disposition index). These findings suggest that the hearing loss associated with HI-T2DM is predominantly cochlear, and auditory structures underlying the higher frequencies are at risk with HI-T2DM. Loss of auditory function begins in the hyperinsulinemia, pre-diabetic state.
DOI: 10.1016/j.heares.2015.07.001
PubMed: 26163094
PubMed Central: PMC4581975
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Fowler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Communication Sciences and Disorders, University of Wisconsin-Madison, 1975 Willow Drive Madison, Madison, WI 53706, USA. Electronic address: cgfowler@wisc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Communication Sciences and Disorders, University of Wisconsin-Madison, 1975 Willow Drive Madison, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Chiasson, Kirstin Beach" sort="Chiasson, Kirstin Beach" uniqKey="Chiasson K" first="Kirstin Beach" last="Chiasson">Kirstin Beach Chiasson</name><affiliation wicri:level="2"><nlm:affiliation>Cascade Ear, Nose, Throat, and Facial Plastic Surgery, Klamath Falls, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cascade Ear, Nose, Throat, and Facial Plastic Surgery, Klamath Falls, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Colman, Ricki J" sort="Colman, Ricki J" uniqKey="Colman R" first="Ricki J" last="Colman">Ricki J. Colman</name><affiliation wicri:level="2"><nlm:affiliation>Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA. Electronic address: rcolman@primate.wisc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Kemnitz, Joseph W" sort="Kemnitz, Joseph W" uniqKey="Kemnitz J" first="Joseph W" last="Kemnitz">Joseph W. Kemnitz</name><affiliation wicri:level="2"><nlm:affiliation>Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA. 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Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705-2286</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">Hearing research</title><idno type="eISSN">1878-5891</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (MeSH)</term><term>Animals (MeSH)</term><term>Auditory Threshold (physiology)</term><term>Blood Glucose (analysis)</term><term>Body Mass Index (MeSH)</term><term>Caloric Restriction (MeSH)</term><term>Cochlea (physiology)</term><term>Diabetes Complications (MeSH)</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (physiopathology)</term><term>Evoked Potentials, Auditory, Brain Stem (physiology)</term><term>Female (MeSH)</term><term>Hearing (MeSH)</term><term>Hearing Loss (complications)</term><term>Hyperinsulinism (complications)</term><term>Hyperinsulinism (physiopathology)</term><term>Life Style (MeSH)</term><term>Macaca mulatta (MeSH)</term><term>Male (MeSH)</term><term>Models, Animal (MeSH)</term><term>Otoacoustic Emissions, Spontaneous (physiology)</term><term>Prediabetic State (complications)</term><term>Reproducibility of Results (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Signal-To-Noise Ratio (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Cochlée (physiologie)</term><term>Complications du diabète (MeSH)</term><term>Diabète de type 2 (complications)</term><term>Diabète de type 2 (physiopathologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Glycémie (analyse)</term><term>Hyperinsulinisme (complications)</term><term>Hyperinsulinisme (physiopathologie)</term><term>Indice de masse corporelle (MeSH)</term><term>Macaca mulatta (MeSH)</term><term>Mode de vie (MeSH)</term><term>Modèles animaux (MeSH)</term><term>Mâle (MeSH)</term><term>Ouïe (MeSH)</term><term>Perte d'audition (complications)</term><term>Potentiels évoqués auditifs du tronc cérébral (physiologie)</term><term>Rapport signal-bruit (MeSH)</term><term>Reproductibilité des résultats (MeSH)</term><term>Restriction calorique (MeSH)</term><term>Seuil auditif (physiologie)</term><term>Vieillissement (MeSH)</term><term>Émissions otoacoustiques spontanées (physiologie)</term><term>État prédiabétique (complications)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Glycémie</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Hearing Loss</term><term>Hyperinsulinism</term><term>Prediabetic State</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cochlée</term><term>Potentiels évoqués auditifs du tronc cérébral</term><term>Seuil auditif</term><term>Émissions otoacoustiques spontanées</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Auditory Threshold</term><term>Cochlea</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Otoacoustic Emissions, Spontaneous</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Diabète de type 2</term><term>Hyperinsulinisme</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Hyperinsulinism</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aging</term><term>Animals</term><term>Body Mass Index</term><term>Caloric Restriction</term><term>Diabetes Complications</term><term>Female</term><term>Hearing</term><term>Life Style</term><term>Macaca mulatta</term><term>Male</term><term>Models, Animal</term><term>Reproducibility of Results</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Signal-To-Noise Ratio</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Animaux</term><term>Complications du diabète</term><term>Diabète de type 2</term><term>Facteurs de risque</term><term>Femelle</term><term>Hyperinsulinisme</term><term>Indice de masse corporelle</term><term>Macaca mulatta</term><term>Mode de vie</term><term>Modèles animaux</term><term>Mâle</term><term>Ouïe</term><term>Perte d'audition</term><term>Rapport signal-bruit</term><term>Reproductibilité des résultats</term><term>Restriction calorique</term><term>Vieillissement</term><term>État prédiabétique</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to determine the effects of hyperinsulinemia/Type 2 diabetes mellitus (HI-T2DM) on hearing impairment using rhesus monkeys to obtain control over diet and lifestyle factors that confound human studies. The study is a retrospective evaluation of rhesus monkeys from the Wisconsin National Primate Research Center (WNPRC) study on caloric restriction and aging. The research questions were the following: 1. Is HI-T2DM related to hearing impairment? 2. If so, what is the site of lesion in the auditory system? and 3. What physiological factors affect the risk of hearing loss in HI-T2DM? Three groups of eight monkeys each were matched by sex and age; the caloric restricted (CR) monkeys had a reduced risk of diabetes, the normal control (NL) group had a normal risk, and the hyperinsulinemia/diabetes (HI-D) group had already developed HI-T2DM. Auditory testing included distortion product otoacoustic emissions (DPOAEs) with f2 frequencies from 2211 to 8837 Hz and auditory brainstem responses (ABRs) obtained with clicks and tone bursts (8, 16, and 32 kHz). DPOAEs had signal-to-noise ratios 8-17 dB larger in the NL group than in the HI-D and CR groups, signifying that cochlear function was best in the NL group. ABR thresholds were 5-8 dB better in the NL group than in the HI-D group, although no significant differences across the groups were evident for the thresholds, latencies, interwave intervals, or amplitudes. Correlations were significant for quadratic relations between body mass index (BMI) and DPOAE, with largest DPOAEs for animals in the middle of the BMI range. ABR thresholds elicited with 16 and 32 kHz signals were significantly correlated, positively with BMI and HbA1c, and negatively with KG (glucose tolerance), SI (insulin sensitivity index) and DI (disposition index). These findings suggest that the hearing loss associated with HI-T2DM is predominantly cochlear, and auditory structures underlying the higher frequencies are at risk with HI-T2DM. Loss of auditory function begins in the hyperinsulinemia, pre-diabetic state. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26163094</PMID><DateCompleted><Year>2016</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5891</ISSN><JournalIssue CitedMedium="Internet"><Volume>328</Volume><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Hearing research</Title><ISOAbbreviation>Hear Res</ISOAbbreviation></Journal><ArticleTitle>Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys.</ArticleTitle><Pagination><MedlinePgn>78-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.heares.2015.07.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-5955(15)00141-0</ELocationID><Abstract><AbstractText>The purpose of this study was to determine the effects of hyperinsulinemia/Type 2 diabetes mellitus (HI-T2DM) on hearing impairment using rhesus monkeys to obtain control over diet and lifestyle factors that confound human studies. The study is a retrospective evaluation of rhesus monkeys from the Wisconsin National Primate Research Center (WNPRC) study on caloric restriction and aging. The research questions were the following: 1. Is HI-T2DM related to hearing impairment? 2. If so, what is the site of lesion in the auditory system? and 3. What physiological factors affect the risk of hearing loss in HI-T2DM? Three groups of eight monkeys each were matched by sex and age; the caloric restricted (CR) monkeys had a reduced risk of diabetes, the normal control (NL) group had a normal risk, and the hyperinsulinemia/diabetes (HI-D) group had already developed HI-T2DM. Auditory testing included distortion product otoacoustic emissions (DPOAEs) with f2 frequencies from 2211 to 8837 Hz and auditory brainstem responses (ABRs) obtained with clicks and tone bursts (8, 16, and 32 kHz). DPOAEs had signal-to-noise ratios 8-17 dB larger in the NL group than in the HI-D and CR groups, signifying that cochlear function was best in the NL group. ABR thresholds were 5-8 dB better in the NL group than in the HI-D group, although no significant differences across the groups were evident for the thresholds, latencies, interwave intervals, or amplitudes. Correlations were significant for quadratic relations between body mass index (BMI) and DPOAE, with largest DPOAEs for animals in the middle of the BMI range. ABR thresholds elicited with 16 and 32 kHz signals were significantly correlated, positively with BMI and HbA1c, and negatively with KG (glucose tolerance), SI (insulin sensitivity index) and DI (disposition index). These findings suggest that the hearing loss associated with HI-T2DM is predominantly cochlear, and auditory structures underlying the higher frequencies are at risk with HI-T2DM. Loss of auditory function begins in the hyperinsulinemia, pre-diabetic state. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fowler</LastName><ForeName>Cynthia G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Communication Sciences and Disorders, University of Wisconsin-Madison, 1975 Willow Drive Madison, Madison, WI 53706, USA. Electronic address: cgfowler@wisc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiasson</LastName><ForeName>Kirstin Beach</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>Cascade Ear, Nose, Throat, and Facial Plastic Surgery, Klamath Falls, OR, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colman</LastName><ForeName>Ricki J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA. Electronic address: rcolman@primate.wisc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kemnitz</LastName><ForeName>Joseph W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715-1299, USA. Electronic address: kemnitz@primate.wisc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beasley</LastName><ForeName>T Mark</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, School of Public Health, Ryals Public Health Bldg., University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: mbeasley@ms.soph.uab.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weindruch</LastName><ForeName>Richard H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Wisconsin-Madison, Room B72 Veterans Admin Hospital, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705-2286, USA. Electronic address: rhweindr@wisc.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>C06 RR020141</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>C06 RR015459</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P51 RR000167</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR15459-01</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR020141-01</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK079626</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG040178</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG040178</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AG011915</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P51 OD011106</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AG 11915</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Hear Res</MedlineTA><NlmUniqueID>7900445</NlmUniqueID><ISSNLinking>0378-5955</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="Y">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001309" MajorTopicYN="N">Auditory Threshold</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031204" 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MajorTopicYN="N">Hearing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034381" MajorTopicYN="N">Hearing Loss</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006946" MajorTopicYN="N">Hyperinsulinism</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008019" MajorTopicYN="N">Life Style</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017084" MajorTopicYN="N">Otoacoustic Emissions, Spontaneous</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011236" MajorTopicYN="N">Prediabetic State</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059629" MajorTopicYN="N">Signal-To-Noise Ratio</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Age-related hearing loss</Keyword><Keyword MajorTopicYN="N">Auditory evoked potentials</Keyword><Keyword MajorTopicYN="N">Caloric restriction</Keyword><Keyword MajorTopicYN="N">Distortion 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IdType="pubmed">21419069</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Oregon</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Fowler, Cynthia G" sort="Fowler, Cynthia G" uniqKey="Fowler C" first="Cynthia G" last="Fowler">Cynthia G. Fowler</name></region><name sortKey="Beasley, T Mark" sort="Beasley, T Mark" uniqKey="Beasley T" first="T Mark" last="Beasley">T Mark Beasley</name><name sortKey="Chiasson, Kirstin Beach" sort="Chiasson, Kirstin Beach" uniqKey="Chiasson K" first="Kirstin Beach" last="Chiasson">Kirstin Beach Chiasson</name><name sortKey="Colman, Ricki J" sort="Colman, Ricki J" uniqKey="Colman R" first="Ricki J" last="Colman">Ricki J. Colman</name><name sortKey="Kemnitz, Joseph W" sort="Kemnitz, Joseph W" uniqKey="Kemnitz J" first="Joseph W" last="Kemnitz">Joseph W. Kemnitz</name><name sortKey="Weindruch, Richard H" sort="Weindruch, Richard H" uniqKey="Weindruch R" first="Richard H" last="Weindruch">Richard H. Weindruch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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