The Utility of Spot vs 24-Hour Urine Samples for Metal Determination in Veterans With Retained Fragments.
Identifieur interne : 000056 ( Main/Exploration ); précédent : 000055; suivant : 000057The Utility of Spot vs 24-Hour Urine Samples for Metal Determination in Veterans With Retained Fragments.
Auteurs : Joanna M. Gaitens [États-Unis] ; Clayton H. Brown [États-Unis] ; Frederick G. Strathmann [États-Unis] ; Hanna Xu [États-Unis] ; Michael R. Lewin-Smith [États-Unis] ; Maria A. Velez-Quinones [États-Unis] ; Melissa A. Mcdiarmid [États-Unis]Source :
- American journal of clinical pathology [ 1943-7722 ] ; 2020.
Abstract
OBJECTIVES
The objective of this investigation is to explore the utility of using a spot urine sample in lieu of a 24-hour collection in assessing fragment-related metal exposure in war-injured veterans.
METHODS
Twenty-four veterans collected each urine void over a 24-hour period in separate containers. Concentrations of 13 metals were measured in each void and in a pooled 24-hour sample using inductively coupled plasma mass spectrometry. To assess the reliability of spot sample measures over time, intraclass correlations (ICCs) were calculated across all spot samples. Lin's concordance correlation coefficient was used to assess agreement between a randomly selected spot urine sample and each corresponding 24-hour sample.
RESULTS
In total, 149 spot urine samples were collected. Ten of the 13 metals measured had ICCs more than 0.4, suggesting "fair to good" reliability. Concordance coefficients were more than 0.4 for all metals, suggesting "moderate" agreement between spot and 24-hour concentrations, and more than 0.6 for seven of the 13 metals, suggesting "good" agreement.
CONCLUSIONS
Our fair to good reliability findings, for most metals investigated, and moderate to good agreement findings for all metals, across the range of concentrations observed here, suggest the utility of spot urine samples to obtain valid estimates of exposure in the longitudinal surveillance of metal-exposed populations.
DOI: 10.1093/ajcp/aqaa144
PubMed: 33083816
Affiliations:
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Gaitens</name><affiliation wicri:level="2"><nlm:affiliation>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore</wicri:cityArea></affiliation><affiliation><nlm:affiliation>Department of Medicine, Division of Occupational and Environmental Medicine.</nlm:affiliation><wicri:noCountry code="subField">Division of Occupational and Environmental Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Brown, Clayton H" sort="Brown, Clayton H" uniqKey="Brown C" first="Clayton H" last="Brown">Clayton H. Brown</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Epidemiology & Public Health, University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Strathmann, Frederick G" sort="Strathmann, Frederick G" uniqKey="Strathmann F" first="Frederick G" last="Strathmann">Frederick G. Strathmann</name><affiliation wicri:level="2"><nlm:affiliation>NMS Labs, Willow Grove, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>NMS Labs, Willow Grove</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Hanna" sort="Xu, Hanna" uniqKey="Xu H" first="Hanna" last="Xu">Hanna Xu</name><affiliation wicri:level="2"><nlm:affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring</wicri:cityArea></affiliation></author><author><name sortKey="Lewin Smith, Michael R" sort="Lewin Smith, Michael R" uniqKey="Lewin Smith M" first="Michael R" last="Lewin-Smith">Michael R. Lewin-Smith</name><affiliation wicri:level="2"><nlm:affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring</wicri:cityArea></affiliation></author><author><name sortKey="Velez Quinones, Maria A" sort="Velez Quinones, Maria A" uniqKey="Velez Quinones M" first="Maria A" last="Velez-Quinones">Maria A. Velez-Quinones</name><affiliation wicri:level="2"><nlm:affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring</wicri:cityArea></affiliation></author><author><name sortKey="Mcdiarmid, Melissa A" sort="Mcdiarmid, Melissa A" uniqKey="Mcdiarmid M" first="Melissa A" last="Mcdiarmid">Melissa A. Mcdiarmid</name><affiliation wicri:level="2"><nlm:affiliation>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore</wicri:cityArea></affiliation><affiliation><nlm:affiliation>Department of Medicine, Division of Occupational and Environmental Medicine.</nlm:affiliation><wicri:noCountry code="subField">Division of Occupational and Environmental Medicine</wicri:noCountry></affiliation></author></analytic><series><title level="j">American journal of clinical pathology</title><idno type="eISSN">1943-7722</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>The objective of this investigation is to explore the utility of using a spot urine sample in lieu of a 24-hour collection in assessing fragment-related metal exposure in war-injured veterans.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Twenty-four veterans collected each urine void over a 24-hour period in separate containers. Concentrations of 13 metals were measured in each void and in a pooled 24-hour sample using inductively coupled plasma mass spectrometry. To assess the reliability of spot sample measures over time, intraclass correlations (ICCs) were calculated across all spot samples. Lin's concordance correlation coefficient was used to assess agreement between a randomly selected spot urine sample and each corresponding 24-hour sample.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In total, 149 spot urine samples were collected. Ten of the 13 metals measured had ICCs more than 0.4, suggesting "fair to good" reliability. Concordance coefficients were more than 0.4 for all metals, suggesting "moderate" agreement between spot and 24-hour concentrations, and more than 0.6 for seven of the 13 metals, suggesting "good" agreement.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our fair to good reliability findings, for most metals investigated, and moderate to good agreement findings for all metals, across the range of concentrations observed here, suggest the utility of spot urine samples to obtain valid estimates of exposure in the longitudinal surveillance of metal-exposed populations.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33083816</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1943-7722</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Oct</Month><Day>21</Day></PubDate></JournalIssue><Title>American journal of clinical pathology</Title><ISOAbbreviation>Am J Clin Pathol</ISOAbbreviation></Journal><ArticleTitle>The Utility of Spot vs 24-Hour Urine Samples for Metal Determination in Veterans With Retained Fragments.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">aqaa144</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/ajcp/aqaa144</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objective of this investigation is to explore the utility of using a spot urine sample in lieu of a 24-hour collection in assessing fragment-related metal exposure in war-injured veterans.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty-four veterans collected each urine void over a 24-hour period in separate containers. Concentrations of 13 metals were measured in each void and in a pooled 24-hour sample using inductively coupled plasma mass spectrometry. To assess the reliability of spot sample measures over time, intraclass correlations (ICCs) were calculated across all spot samples. Lin's concordance correlation coefficient was used to assess agreement between a randomly selected spot urine sample and each corresponding 24-hour sample.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 149 spot urine samples were collected. Ten of the 13 metals measured had ICCs more than 0.4, suggesting "fair to good" reliability. Concordance coefficients were more than 0.4 for all metals, suggesting "moderate" agreement between spot and 24-hour concentrations, and more than 0.6 for seven of the 13 metals, suggesting "good" agreement.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our fair to good reliability findings, for most metals investigated, and moderate to good agreement findings for all metals, across the range of concentrations observed here, suggest the utility of spot urine samples to obtain valid estimates of exposure in the longitudinal surveillance of metal-exposed populations.</AbstractText><CopyrightInformation>© American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaitens</LastName><ForeName>Joanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore, MD.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Division of Occupational and Environmental Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Clayton H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strathmann</LastName><ForeName>Frederick G</ForeName><Initials>FG</Initials><AffiliationInfo><Affiliation>NMS Labs, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Hanna</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewin-Smith</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velez-Quinones</LastName><ForeName>Maria A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>The Joint Pathology Center, Environmental Toxicology Laboratory, Silver Spring, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDiarmid</LastName><ForeName>Melissa A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Veterans Affairs, Baltimore VA Medical Center, Baltimore, MD.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Division of Occupational and Environmental Medicine.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Am J Clin Pathol</MedlineTA><NlmUniqueID>0370470</NlmUniqueID><ISSNLinking>0002-9173</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Embedded fragments</Keyword><Keyword MajorTopicYN="N">Medical surveillance</Keyword><Keyword MajorTopicYN="N">Urine metal concentrations</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>5</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33083816</ArticleId><ArticleId IdType="pii">5933874</ArticleId><ArticleId IdType="doi">10.1093/ajcp/aqaa144</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Pennsylvanie</li></region><settlement><li>Baltimore</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Gaitens, Joanna M" sort="Gaitens, Joanna M" uniqKey="Gaitens J" first="Joanna M" last="Gaitens">Joanna M. Gaitens</name></region><name sortKey="Brown, Clayton H" sort="Brown, Clayton H" uniqKey="Brown C" first="Clayton H" last="Brown">Clayton H. Brown</name><name sortKey="Lewin Smith, Michael R" sort="Lewin Smith, Michael R" uniqKey="Lewin Smith M" first="Michael R" last="Lewin-Smith">Michael R. Lewin-Smith</name><name sortKey="Mcdiarmid, Melissa A" sort="Mcdiarmid, Melissa A" uniqKey="Mcdiarmid M" first="Melissa A" last="Mcdiarmid">Melissa A. Mcdiarmid</name><name sortKey="Strathmann, Frederick G" sort="Strathmann, Frederick G" uniqKey="Strathmann F" first="Frederick G" last="Strathmann">Frederick G. Strathmann</name><name sortKey="Velez Quinones, Maria A" sort="Velez Quinones, Maria A" uniqKey="Velez Quinones M" first="Maria A" last="Velez-Quinones">Maria A. Velez-Quinones</name><name sortKey="Xu, Hanna" sort="Xu, Hanna" uniqKey="Xu H" first="Hanna" last="Xu">Hanna Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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