Quantitative determination of phenelzine in human fluids by gas chromatography with nitrogen specific detection.
Identifieur interne : 002442 ( Main/Corpus ); précédent : 002441; suivant : 002443Quantitative determination of phenelzine in human fluids by gas chromatography with nitrogen specific detection.
Auteurs : M. Lichtenwalner ; M. Mcmullin ; D. Hardy ; F. RiedersSource :
- Journal of analytical toxicology [ 0146-4760 ]
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Nitrogen, Phenelzine.
- analysis : Body Fluids.
- chemical , blood : Phenelzine.
- Chromatography, Gas, Cyclization, Gas Chromatography-Mass Spectrometry, Humans, Pentanones, Solvents.
Abstract
A quantitative gas chromatographic assay for the determination of phenelzine in plasma or other fluids is presented. A stable derivative is formed by cyclization with acetylacetone, and the derivative is separated, purified, and concentrated by liquid-liquid solvent extraction. Analysis of the extracts is by capillary gas chromatography with nitrogen specific detection. Detection limits of less than 1 ng/mL and CVs of 5% at the 10-ng/mL level are attainable with a 2-mL sample and benzylhydrazine as the internal standard.
DOI: 10.1093/jat/12.2.98
PubMed: 3379930
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pubmed:3379930Le document en format XML
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Rieders</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1988">1988 Mar-Apr</date><idno type="RBID">pubmed:3379930</idno><idno type="pmid">3379930</idno><idno type="doi">10.1093/jat/12.2.98</idno><idno type="wicri:Area/Main/Corpus">002442</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002442</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative determination of phenelzine in human fluids by gas chromatography with nitrogen specific detection.</title><author><name sortKey="Lichtenwalner, M" sort="Lichtenwalner, M" uniqKey="Lichtenwalner M" first="M" last="Lichtenwalner">M. Lichtenwalner</name><affiliation><nlm:affiliation>National Medical Services, Willow Grove, Pennsylvania 19090.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmullin, M" sort="Mcmullin, M" uniqKey="Mcmullin M" first="M" last="Mcmullin">M. Mcmullin</name></author><author><name sortKey="Hardy, D" sort="Hardy, D" uniqKey="Hardy D" first="D" last="Hardy">D. Hardy</name></author><author><name sortKey="Rieders, F" sort="Rieders, F" uniqKey="Rieders F" first="F" last="Rieders">F. Rieders</name></author></analytic><series><title level="j">Journal of analytical toxicology</title><idno type="ISSN">0146-4760</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Fluids (analysis)</term><term>Chromatography, Gas (MeSH)</term><term>Cyclization (MeSH)</term><term>Gas Chromatography-Mass Spectrometry (MeSH)</term><term>Humans (MeSH)</term><term>Nitrogen (analysis)</term><term>Pentanones (MeSH)</term><term>Phenelzine (analysis)</term><term>Phenelzine (blood)</term><term>Solvents (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nitrogen</term><term>Phenelzine</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Body Fluids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Phenelzine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, Gas</term><term>Cyclization</term><term>Gas Chromatography-Mass Spectrometry</term><term>Humans</term><term>Pentanones</term><term>Solvents</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A quantitative gas chromatographic assay for the determination of phenelzine in plasma or other fluids is presented. A stable derivative is formed by cyclization with acetylacetone, and the derivative is separated, purified, and concentrated by liquid-liquid solvent extraction. Analysis of the extracts is by capillary gas chromatography with nitrogen specific detection. Detection limits of less than 1 ng/mL and CVs of 5% at the 10-ng/mL level are attainable with a 2-mL sample and benzylhydrazine as the internal standard.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3379930</PMID><DateCompleted><Year>1988</Year><Month>07</Month><Day>19</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0146-4760</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><Issue>2</Issue><PubDate><MedlineDate>1988 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Journal of analytical toxicology</Title><ISOAbbreviation>J Anal Toxicol</ISOAbbreviation></Journal><ArticleTitle>Quantitative determination of phenelzine in human fluids by gas chromatography with nitrogen specific detection.</ArticleTitle><Pagination><MedlinePgn>98-101</MedlinePgn></Pagination><Abstract><AbstractText>A quantitative gas chromatographic assay for the determination of phenelzine in plasma or other fluids is presented. A stable derivative is formed by cyclization with acetylacetone, and the derivative is separated, purified, and concentrated by liquid-liquid solvent extraction. Analysis of the extracts is by capillary gas chromatography with nitrogen specific detection. Detection limits of less than 1 ng/mL and CVs of 5% at the 10-ng/mL level are attainable with a 2-mL sample and benzylhydrazine as the internal standard.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lichtenwalner</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Medical Services, Willow Grove, Pennsylvania 19090.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMullin</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Rieders</LastName><ForeName>F</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Anal Toxicol</MedlineTA><NlmUniqueID>7705085</NlmUniqueID><ISSNLinking>0146-4760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010422">Pentanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012997">Solvents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46R950BP4J</RegistryNumber><NameOfSubstance UI="C008790">acetylacetone</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>O408N561GF</RegistryNumber><NameOfSubstance UI="D010624">Phenelzine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>J Anal Toxicol 1988 Sep-Oct;12(5):15</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001826" MajorTopicYN="N">Body Fluids</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002849" MajorTopicYN="N">Chromatography, Gas</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003500" MajorTopicYN="N">Cyclization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010422" MajorTopicYN="N">Pentanones</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010624" MajorTopicYN="N">Phenelzine</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012997" MajorTopicYN="N">Solvents</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1988</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3379930</ArticleId><ArticleId IdType="doi">10.1093/jat/12.2.98</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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