Comparison between skin testing and in vitro testing for diagnosis of allergen in asthmatic children.
Identifieur interne : 002304 ( Main/Corpus ); précédent : 002303; suivant : 002305Comparison between skin testing and in vitro testing for diagnosis of allergen in asthmatic children.
Auteurs : R B Tang ; K G Wu ; B. HwangSource :
- Zhonghua yi xue za zhi = Chinese medical journal; Free China ed [ 0578-1337 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Allergens.
- diagnosis : Asthma.
- immunology : Asthma.
- Adolescent, Child, Child, Preschool, Humans, Luminescent Measurements, Predictive Value of Tests, Radioallergosorbent Test, Sensitivity and Specificity, Skin Tests.
Abstract
BACKGROUND
This study was designed to compare the skin testing and in vitro testing for the diagnosis of most common inhalant allergens in asthmatic children.
METHODS
Sixty-two asthmatic children positive to most common allergens in the area of skin tests and multiple allergosorbent chemiluminescent assay (MAST-CLA) were subjected to another Pharmacia CAP test (CAP).
RESULTS
The agreement between the results of MAST-CLA and CAP was variable. The correlation coefficient for CAP with MAST-CLA was significant for five allergens except candida, dog dander and Willow pollen when the diagnostic levels of MAST-CLA and CAP were compared with skin test reactions. For all the allergens tested, MAST-CLA showed a sensitivity of 51%, a specificity of 84% and an efficiency of 73%, compared with 57%, 80% and 74%, respectively, in the CAP analysis.
CONCLUSIONS
MAST-CLA and CAP can be used as a screening test to measure allergen IgE level. Both MAST-CLA and CAP were comparable in their ability to diagnose of allergy to tested allergens.
PubMed: 7982135
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Hwang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7982135</idno><idno type="pmid">7982135</idno><idno type="wicri:Area/Main/Corpus">002304</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002304</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison between skin testing and in vitro testing for diagnosis of allergen in asthmatic children.</title><author><name sortKey="Tang, R B" sort="Tang, R B" uniqKey="Tang R" first="R B" last="Tang">R B Tang</name><affiliation><nlm:affiliation>Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan, R.O.C.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, K G" sort="Wu, K G" uniqKey="Wu K" first="K G" last="Wu">K G Wu</name></author><author><name sortKey="Hwang, B" sort="Hwang, B" uniqKey="Hwang B" first="B" last="Hwang">B. Hwang</name></author></analytic><series><title level="j">Zhonghua yi xue za zhi = Chinese medical journal; Free China ed</title><idno type="ISSN">0578-1337</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Allergens (immunology)</term><term>Asthma (diagnosis)</term><term>Asthma (immunology)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Humans (MeSH)</term><term>Luminescent Measurements (MeSH)</term><term>Predictive Value of Tests (MeSH)</term><term>Radioallergosorbent Test (MeSH)</term><term>Sensitivity and Specificity (MeSH)</term><term>Skin Tests (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Allergens</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Luminescent Measurements</term><term>Predictive Value of Tests</term><term>Radioallergosorbent Test</term><term>Sensitivity and Specificity</term><term>Skin Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>This study was designed to compare the skin testing and in vitro testing for the diagnosis of most common inhalant allergens in asthmatic children.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Sixty-two asthmatic children positive to most common allergens in the area of skin tests and multiple allergosorbent chemiluminescent assay (MAST-CLA) were subjected to another Pharmacia CAP test (CAP).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The agreement between the results of MAST-CLA and CAP was variable. The correlation coefficient for CAP with MAST-CLA was significant for five allergens except candida, dog dander and Willow pollen when the diagnostic levels of MAST-CLA and CAP were compared with skin test reactions. For all the allergens tested, MAST-CLA showed a sensitivity of 51%, a specificity of 84% and an efficiency of 73%, compared with 57%, 80% and 74%, respectively, in the CAP analysis.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>MAST-CLA and CAP can be used as a screening test to measure allergen IgE level. Both MAST-CLA and CAP were comparable in their ability to diagnose of allergy to tested allergens.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7982135</PMID><DateCompleted><Year>1995</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0578-1337</ISSN><JournalIssue CitedMedium="Print"><Volume>54</Volume><Issue>4</Issue><PubDate><Year>1994</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Zhonghua yi xue za zhi = Chinese medical journal; Free China ed</Title><ISOAbbreviation>Zhonghua Yi Xue Za Zhi (Taipei)</ISOAbbreviation></Journal><ArticleTitle>Comparison between skin testing and in vitro testing for diagnosis of allergen in asthmatic children.</ArticleTitle><Pagination><MedlinePgn>246-50</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study was designed to compare the skin testing and in vitro testing for the diagnosis of most common inhalant allergens in asthmatic children.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Sixty-two asthmatic children positive to most common allergens in the area of skin tests and multiple allergosorbent chemiluminescent assay (MAST-CLA) were subjected to another Pharmacia CAP test (CAP).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The agreement between the results of MAST-CLA and CAP was variable. The correlation coefficient for CAP with MAST-CLA was significant for five allergens except candida, dog dander and Willow pollen when the diagnostic levels of MAST-CLA and CAP were compared with skin test reactions. For all the allergens tested, MAST-CLA showed a sensitivity of 51%, a specificity of 84% and an efficiency of 73%, compared with 57%, 80% and 74%, respectively, in the CAP analysis.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MAST-CLA and CAP can be used as a screening test to measure allergen IgE level. Both MAST-CLA and CAP were comparable in their ability to diagnose of allergy to tested allergens.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>R B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan, R.O.C.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>K G</ForeName><Initials>KG</Initials></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China (Republic : 1949- )</Country><MedlineTA>Zhonghua Yi Xue Za Zhi (Taipei)</MedlineTA><NlmUniqueID>0005327</NlmUniqueID><ISSNLinking>0578-1337</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000485">Allergens</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000485" MajorTopicYN="N">Allergens</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008163" MajorTopicYN="N">Luminescent Measurements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011852" MajorTopicYN="N">Radioallergosorbent Test</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012882" MajorTopicYN="N">Skin Tests</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7982135</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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