A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.
Identifieur interne : 001E27 ( Main/Corpus ); précédent : 001E26; suivant : 001E28A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.
Auteurs : Kap-Hoon Han ; Jeong-Ah Seo ; Jae-Hyuk YuSource :
- Molecular microbiology [ 0950-382X ] ; 2004.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Aspergillus nidulans (cytology), Aspergillus nidulans (genetics), Aspergillus nidulans (growth & development), Aspergillus nidulans (physiology), Cyclic AMP-Dependent Protein Kinases (metabolism), Fungal Proteins (genetics), Fungal Proteins (metabolism), Genes, Fungal (MeSH), Heterotrimeric GTP-Binding Proteins (metabolism), Molecular Sequence Data (MeSH), Mutation (MeSH), Phenotype (MeSH), Phylogeny (MeSH), Protein Kinase C (metabolism), Receptors, G-Protein-Coupled (classification), Receptors, G-Protein-Coupled (genetics), Receptors, G-Protein-Coupled (metabolism), Sequence Alignment (MeSH), Signal Transduction (physiology), Temperature (MeSH).
- MESH :
- chemical , classification : Receptors, G-Protein-Coupled.
- chemical , genetics : Fungal Proteins, Receptors, G-Protein-Coupled.
- chemical , metabolism : Cyclic AMP-Dependent Protein Kinases, Fungal Proteins, Heterotrimeric GTP-Binding Proteins, Protein Kinase C, Receptors, G-Protein-Coupled.
- cytology : Aspergillus nidulans.
- genetics : Aspergillus nidulans.
- growth & development : Aspergillus nidulans.
- physiology : Aspergillus nidulans, Signal Transduction.
- Amino Acid Sequence, Animals, Genes, Fungal, Molecular Sequence Data, Mutation, Phenotype, Phylogeny, Sequence Alignment, Temperature.
Abstract
G protein-coupled receptors (GPCRs) are key components of heterotrimeric G protein-mediated signalling pathways that detect environmental signals and confer rapid cellular responses. To broaden our understanding of signalling mechanisms in the filamentous fungus Aspergillus nidulans, intensive analyses of the Aspergillus nidulans genome have been carried out and nine genes (gprA approximately gprI) that are predicted to encode seven transmembrane spanning GPCRs have been identified. Six of nine putative GPCRs have been disrupted and the gprD gene was found to play a central role in coordinating hyphal growth and sexual development. Deletion of gprD (Delta gprD) causes extremely restricted hyphal growth, delayed conidial germination and uncontrolled activation of sexual development resulting in a small colony covered by sexual fruiting bodies. Genetic studies indicate that GprD may not signal through the FadA (G alpha)-protein kinase A (PKA) pathway. Elimination of sexual development rescues both growth and developmental abnormalities caused by Delta gprD, suggesting that the primary role of GprD is to negatively regulate sexual development. This is supported by the fact that environmental conditions inhibiting sexual development suppress growth defects of the Delta gprD mutant. We propose that the GprD-mediated signalling cascade negatively regulates sexual development, which is required for proper proliferation of A. nidulans.
DOI: 10.1111/j.1365-2958.2003.03940.x
PubMed: 14982628
Links to Exploration step
pubmed:14982628Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.</title><author><name sortKey="Han, Kap Hoon" sort="Han, Kap Hoon" uniqKey="Han K" first="Kap-Hoon" last="Han">Kap-Hoon Han</name><affiliation><nlm:affiliation>Department of Food Microbiology and Toxicology and Food Research Institute, Molecular and Environmental Toxicology Center, 1925 Willow Drive, University of Wisconsin, Madison, 53706, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seo, Jeong Ah" sort="Seo, Jeong Ah" uniqKey="Seo J" first="Jeong-Ah" last="Seo">Jeong-Ah Seo</name></author><author><name sortKey="Yu, Jae Hyuk" sort="Yu, Jae Hyuk" uniqKey="Yu J" first="Jae-Hyuk" last="Yu">Jae-Hyuk Yu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:14982628</idno><idno type="pmid">14982628</idno><idno type="doi">10.1111/j.1365-2958.2003.03940.x</idno><idno type="wicri:Area/Main/Corpus">001E27</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001E27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.</title><author><name sortKey="Han, Kap Hoon" sort="Han, Kap Hoon" uniqKey="Han K" first="Kap-Hoon" last="Han">Kap-Hoon Han</name><affiliation><nlm:affiliation>Department of Food Microbiology and Toxicology and Food Research Institute, Molecular and Environmental Toxicology Center, 1925 Willow Drive, University of Wisconsin, Madison, 53706, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seo, Jeong Ah" sort="Seo, Jeong Ah" uniqKey="Seo J" first="Jeong-Ah" last="Seo">Jeong-Ah Seo</name></author><author><name sortKey="Yu, Jae Hyuk" sort="Yu, Jae Hyuk" uniqKey="Yu J" first="Jae-Hyuk" last="Yu">Jae-Hyuk Yu</name></author></analytic><series><title level="j">Molecular microbiology</title><idno type="ISSN">0950-382X</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Aspergillus nidulans (cytology)</term><term>Aspergillus nidulans (genetics)</term><term>Aspergillus nidulans (growth & development)</term><term>Aspergillus nidulans (physiology)</term><term>Cyclic AMP-Dependent Protein Kinases (metabolism)</term><term>Fungal Proteins (genetics)</term><term>Fungal Proteins (metabolism)</term><term>Genes, Fungal (MeSH)</term><term>Heterotrimeric GTP-Binding Proteins (metabolism)</term><term>Molecular Sequence Data (MeSH)</term><term>Mutation (MeSH)</term><term>Phenotype (MeSH)</term><term>Phylogeny (MeSH)</term><term>Protein Kinase C (metabolism)</term><term>Receptors, G-Protein-Coupled (classification)</term><term>Receptors, G-Protein-Coupled (genetics)</term><term>Receptors, G-Protein-Coupled (metabolism)</term><term>Sequence Alignment (MeSH)</term><term>Signal Transduction (physiology)</term><term>Temperature (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclic AMP-Dependent Protein Kinases</term><term>Fungal Proteins</term><term>Heterotrimeric GTP-Binding Proteins</term><term>Protein Kinase C</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Aspergillus nidulans</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aspergillus nidulans</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Aspergillus nidulans</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aspergillus nidulans</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Genes, Fungal</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Phenotype</term><term>Phylogeny</term><term>Sequence Alignment</term><term>Temperature</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">G protein-coupled receptors (GPCRs) are key components of heterotrimeric G protein-mediated signalling pathways that detect environmental signals and confer rapid cellular responses. To broaden our understanding of signalling mechanisms in the filamentous fungus Aspergillus nidulans, intensive analyses of the Aspergillus nidulans genome have been carried out and nine genes (gprA approximately gprI) that are predicted to encode seven transmembrane spanning GPCRs have been identified. Six of nine putative GPCRs have been disrupted and the gprD gene was found to play a central role in coordinating hyphal growth and sexual development. Deletion of gprD (Delta gprD) causes extremely restricted hyphal growth, delayed conidial germination and uncontrolled activation of sexual development resulting in a small colony covered by sexual fruiting bodies. Genetic studies indicate that GprD may not signal through the FadA (G alpha)-protein kinase A (PKA) pathway. Elimination of sexual development rescues both growth and developmental abnormalities caused by Delta gprD, suggesting that the primary role of GprD is to negatively regulate sexual development. This is supported by the fact that environmental conditions inhibiting sexual development suppress growth defects of the Delta gprD mutant. We propose that the GprD-mediated signalling cascade negatively regulates sexual development, which is required for proper proliferation of A. nidulans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14982628</PMID><DateCompleted><Year>2004</Year><Month>08</Month><Day>09</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0950-382X</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>5</Issue><PubDate><Year>2004</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Molecular microbiology</Title><ISOAbbreviation>Mol Microbiol</ISOAbbreviation></Journal><ArticleTitle>A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.</ArticleTitle><Pagination><MedlinePgn>1333-45</MedlinePgn></Pagination><Abstract><AbstractText>G protein-coupled receptors (GPCRs) are key components of heterotrimeric G protein-mediated signalling pathways that detect environmental signals and confer rapid cellular responses. To broaden our understanding of signalling mechanisms in the filamentous fungus Aspergillus nidulans, intensive analyses of the Aspergillus nidulans genome have been carried out and nine genes (gprA approximately gprI) that are predicted to encode seven transmembrane spanning GPCRs have been identified. Six of nine putative GPCRs have been disrupted and the gprD gene was found to play a central role in coordinating hyphal growth and sexual development. Deletion of gprD (Delta gprD) causes extremely restricted hyphal growth, delayed conidial germination and uncontrolled activation of sexual development resulting in a small colony covered by sexual fruiting bodies. Genetic studies indicate that GprD may not signal through the FadA (G alpha)-protein kinase A (PKA) pathway. Elimination of sexual development rescues both growth and developmental abnormalities caused by Delta gprD, suggesting that the primary role of GprD is to negatively regulate sexual development. This is supported by the fact that environmental conditions inhibiting sexual development suppress growth defects of the Delta gprD mutant. We propose that the GprD-mediated signalling cascade negatively regulates sexual development, which is required for proper proliferation of A. nidulans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Kap-Hoon</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Department of Food Microbiology and Toxicology and Food Research Institute, Molecular and Environmental Toxicology Center, 1925 Willow Drive, University of Wisconsin, Madison, 53706, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seo</LastName><ForeName>Jeong-Ah</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Jae-Hyuk</ForeName><Initials>JH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol Microbiol</MedlineTA><NlmUniqueID>8712028</NlmUniqueID><ISSNLinking>0950-382X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D043562">Receptors, G-Protein-Coupled</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.11</RegistryNumber><NameOfSubstance UI="D017868">Cyclic AMP-Dependent Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.13</RegistryNumber><NameOfSubstance UI="D011493">Protein Kinase C</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.5.1</RegistryNumber><NameOfSubstance UI="D020962">Heterotrimeric GTP-Binding 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