WillowV1, Main, Corpus, bibRecord, 001174

Kynurenic acid content in anti-rheumatic herbs.

Identifieur interne : 001174 ( Main/Corpus ); précédent : 001173; suivant : 001175

Kynurenic acid content in anti-rheumatic herbs.

Auteurs : Wojciech Zgrajka ; Monika Turska ; Gra Yna Rajtar ; Maria Majdan ; Jolanta Parada-Turska

Source :

Annals of agricultural and environmental medicine : AAEM [ 1898-2263 ] ; 2013.

RBID : pubmed:24364456

English descriptors

KwdEn :
- Humans (MeSH), Kynurenic Acid (chemistry), Plant Preparations (analysis), Plant Preparations (therapeutic use), Plants, Medicinal (chemistry), Rheumatic Diseases (drug therapy).
MESH :
- chemical , analysis : Plant Preparations.
- chemical , chemistry : Kynurenic Acid.
- chemical , therapeutic use : Plant Preparations.
- chemistry : Plants, Medicinal.
- drug therapy : Rheumatic Diseases.
- Humans.

Abstract

INTRODUCTION

The use of herbal medicines is common among people living in rural areas and increasingly popular in urbanized countries. Kynurenic acid (KYNA) is a metabolite of kynurenine possessing anti-inflammatory, anti-oxidative and pain reliving properties. Previous data indicated that the content of KYNA in the synovial fluid of patients with rheumatoid arthritis is lower than in patients with osteoarthritis. Rheumatoid arthritis is a chronic, systemic inflammatory disorder affecting about 1% of the world's population.

AIM

The aim of the presented study was to investigate the content of KYNA in 11 herbal preparations used in rheumatic diseases.

MATERIALS AND METHODS

The following herbs were studied: bean pericarp, birch leaf, dandelion root, elder flower, horsetail herb, nettle leaf, peppermint leaf and willow bark. An anti-rheumatic mixture of the herbs Reumatefix and Reumaflos tea were also investigated. The herbs were prepared according to producers' directions. In addition, the herbal supplement Devil's Claw containing root of Harpagophytum was used. KYNA content was measured using the high-performance liquid chromatography method, and KYNA was detected fluorometrically.

RESULTS

KYNA was found in all studied herbal preparations. The highest content of KYNA was found in peppermint, nettle, birch leaf and the horsetail herb. The lowest content of KYNA was found in willow bark, dandelion root and in the extract from the root of Harpagophytum.

CONCLUSION

These findings indicate that the use of herbal preparations containing a high level of KYNA can be considered as a supplementary measure in rheumatoid arthritis therapy, as well as in rheumatic diseases prevention.

PubMed: 24364456

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pubmed:24364456

Le document en format XML

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<author><name sortKey="Zgrajka, Wojciech" sort="Zgrajka, Wojciech" uniqKey="Zgrajka W" first="Wojciech" last="Zgrajka">Wojciech Zgrajka</name>
<affiliation><nlm:affiliation>Department of Toxicology, Institute of Rural Health, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Turska, Monika" sort="Turska, Monika" uniqKey="Turska M" first="Monika" last="Turska">Monika Turska</name>
<affiliation><nlm:affiliation>Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rajtar, Gra Yna" sort="Rajtar, Gra Yna" uniqKey="Rajtar G" first="Gra Yna" last="Rajtar">Gra Yna Rajtar</name>
<affiliation><nlm:affiliation>Department of Pharmacology, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Majdan, Maria" sort="Majdan, Maria" uniqKey="Majdan M" first="Maria" last="Majdan">Maria Majdan</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Parada Turska, Jolanta" sort="Parada Turska, Jolanta" uniqKey="Parada Turska J" first="Jolanta" last="Parada-Turska">Jolanta Parada-Turska</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Kynurenic acid content in anti-rheumatic herbs.</title>
<author><name sortKey="Zgrajka, Wojciech" sort="Zgrajka, Wojciech" uniqKey="Zgrajka W" first="Wojciech" last="Zgrajka">Wojciech Zgrajka</name>
<affiliation><nlm:affiliation>Department of Toxicology, Institute of Rural Health, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Turska, Monika" sort="Turska, Monika" uniqKey="Turska M" first="Monika" last="Turska">Monika Turska</name>
<affiliation><nlm:affiliation>Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rajtar, Gra Yna" sort="Rajtar, Gra Yna" uniqKey="Rajtar G" first="Gra Yna" last="Rajtar">Gra Yna Rajtar</name>
<affiliation><nlm:affiliation>Department of Pharmacology, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Majdan, Maria" sort="Majdan, Maria" uniqKey="Majdan M" first="Maria" last="Majdan">Maria Majdan</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Parada Turska, Jolanta" sort="Parada Turska, Jolanta" uniqKey="Parada Turska J" first="Jolanta" last="Parada-Turska">Jolanta Parada-Turska</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.</nlm:affiliation>
</affiliation>
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<series><title level="j">Annals of agricultural and environmental medicine : AAEM</title>
<idno type="eISSN">1898-2263</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans (MeSH)</term>
<term>Kynurenic Acid (chemistry)</term>
<term>Plant Preparations (analysis)</term>
<term>Plant Preparations (therapeutic use)</term>
<term>Plants, Medicinal (chemistry)</term>
<term>Rheumatic Diseases (drug therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Plant Preparations</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Kynurenic Acid</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Preparations</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants, Medicinal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Rheumatic Diseases</term>
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<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>The use of herbal medicines is common among people living in rural areas and increasingly popular in urbanized countries. Kynurenic acid (KYNA) is a metabolite of kynurenine possessing anti-inflammatory, anti-oxidative and pain reliving properties. Previous data indicated that the content of KYNA in the synovial fluid of patients with rheumatoid arthritis is lower than in patients with osteoarthritis. Rheumatoid arthritis is a chronic, systemic inflammatory disorder affecting about 1% of the world's population.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>AIM</b>
</p>
<p>The aim of the presented study was to investigate the content of KYNA in 11 herbal preparations used in rheumatic diseases.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b>
</p>
<p>The following herbs were studied: bean pericarp, birch leaf, dandelion root, elder flower, horsetail herb, nettle leaf, peppermint leaf and willow bark. An anti-rheumatic mixture of the herbs Reumatefix and Reumaflos tea were also investigated. The herbs were prepared according to producers' directions. In addition, the herbal supplement Devil's Claw containing root of Harpagophytum was used. KYNA content was measured using the high-performance liquid chromatography method, and KYNA was detected fluorometrically.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>KYNA was found in all studied herbal preparations. The highest content of KYNA was found in peppermint, nettle, birch leaf and the horsetail herb. The lowest content of KYNA was found in willow bark, dandelion root and in the extract from the root of Harpagophytum.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>These findings indicate that the use of herbal preparations containing a high level of KYNA can be considered as a supplementary measure in rheumatoid arthritis therapy, as well as in rheumatic diseases prevention.</p>
</div>
</front>
</TEI>
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<DateRevised><Year>2013</Year>
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<Title>Annals of agricultural and environmental medicine : AAEM</Title>
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<ArticleTitle>Kynurenic acid content in anti-rheumatic herbs.</ArticleTitle>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The use of herbal medicines is common among people living in rural areas and increasingly popular in urbanized countries. Kynurenic acid (KYNA) is a metabolite of kynurenine possessing anti-inflammatory, anti-oxidative and pain reliving properties. Previous data indicated that the content of KYNA in the synovial fluid of patients with rheumatoid arthritis is lower than in patients with osteoarthritis. Rheumatoid arthritis is a chronic, systemic inflammatory disorder affecting about 1% of the world's population.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">The aim of the presented study was to investigate the content of KYNA in 11 herbal preparations used in rheumatic diseases.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The following herbs were studied: bean pericarp, birch leaf, dandelion root, elder flower, horsetail herb, nettle leaf, peppermint leaf and willow bark. An anti-rheumatic mixture of the herbs Reumatefix and Reumaflos tea were also investigated. The herbs were prepared according to producers' directions. In addition, the herbal supplement Devil's Claw containing root of Harpagophytum was used. KYNA content was measured using the high-performance liquid chromatography method, and KYNA was detected fluorometrically.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">KYNA was found in all studied herbal preparations. The highest content of KYNA was found in peppermint, nettle, birch leaf and the horsetail herb. The lowest content of KYNA was found in willow bark, dandelion root and in the extract from the root of Harpagophytum.</AbstractText>
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Kynurenic acid content in anti-rheumatic herbs.

Kynurenic acid content in anti-rheumatic herbs.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki