WillowV1, Main, Corpus, bibRecord, 000C58

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Identifieur interne : 000C58 ( Main/Corpus ); précédent : 000C57; suivant : 000C59

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Auteurs : Tao P. Wu ; Tao Wang ; Matthew G. Seetin ; Yongquan Lai ; Shijia Zhu ; Kaixuan Lin ; Yifei Liu ; Stephanie D. Byrum ; Samuel G. Mackintosh ; Mei Zhong ; Alan Tackett ; Guilin Wang ; Lawrence S. Hon ; Gang Fang ; James A. Swenberg ; Andrew Z. Xiao

Source :

Nature [ 1476-4687 ] ; 2016.

RBID : pubmed:27027282

English descriptors

KwdEn :
- Adenine (analogs & derivatives), Adenine (metabolism), AlkB Homolog 1, Histone H2a Dioxygenase (MeSH), Animals (MeSH), Cell Differentiation (genetics), DNA Methylation (MeSH), DNA Transposable Elements (genetics), DNA-(Apurinic or Apyrimidinic Site) Lyase (deficiency), DNA-(Apurinic or Apyrimidinic Site) Lyase (genetics), DNA-(Apurinic or Apyrimidinic Site) Lyase (metabolism), Enhancer Elements, Genetic (genetics), Epigenesis, Genetic (genetics), Evolution, Molecular (MeSH), Gene Silencing (MeSH), Long Interspersed Nucleotide Elements (genetics), Mammals (genetics), Mice (MeSH), Mouse Embryonic Stem Cells (cytology), Mouse Embryonic Stem Cells (metabolism), Up-Regulation (genetics), X Chromosome (genetics), X Chromosome (metabolism).
MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , deficiency : DNA-(Apurinic or Apyrimidinic Site) Lyase.
- chemical , genetics : DNA Transposable Elements, DNA-(Apurinic or Apyrimidinic Site) Lyase.
- chemical , metabolism : Adenine, DNA-(Apurinic or Apyrimidinic Site) Lyase.
- chemical : AlkB Homolog 1, Histone H2a Dioxygenase.
- cytology : Mouse Embryonic Stem Cells.
- genetics : Cell Differentiation, Enhancer Elements, Genetic, Epigenesis, Genetic, Long Interspersed Nucleotide Elements, Mammals, Up-Regulation, X Chromosome.
- metabolism : Mouse Embryonic Stem Cells, X Chromosome.
- Animals, DNA Methylation, Evolution, Molecular, Gene Silencing, Mice.

Abstract

It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N(6)-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N(6)-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched at young (<1.5 million years old) but not old (>6 million years old) L1 elements. The deposition of N(6)-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell differentiation. As young full-length LINE-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also silenced. Thus, N(6)-methyladenine developed a new role in epigenetic silencing in mammalian evolution distinct from its role in gene activation in other organisms. Our results demonstrate that N(6)-methyladenine constitutes a crucial component of the epigenetic regulation repertoire in mammalian genomes.

DOI: 10.1038/nature17640
PubMed: 27027282
PubMed Central: PMC4977844

Links to Exploration step

pubmed:27027282

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DNA methylation on N(6)-adenine in mammalian embryonic stem cells.</title>
<author><name sortKey="Wu, Tao P" sort="Wu, Tao P" uniqKey="Wu T" first="Tao P" last="Wu">Tao P. Wu</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Seetin, Matthew G" sort="Seetin, Matthew G" uniqKey="Seetin M" first="Matthew G" last="Seetin">Matthew G. Seetin</name>
<affiliation><nlm:affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lai, Yongquan" sort="Lai, Yongquan" uniqKey="Lai Y" first="Yongquan" last="Lai">Yongquan Lai</name>
<affiliation><nlm:affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhu, Shijia" sort="Zhu, Shijia" uniqKey="Zhu S" first="Shijia" last="Zhu">Shijia Zhu</name>
<affiliation><nlm:affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lin, Kaixuan" sort="Lin, Kaixuan" uniqKey="Lin K" first="Kaixuan" last="Lin">Kaixuan Lin</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yifei" sort="Liu, Yifei" uniqKey="Liu Y" first="Yifei" last="Liu">Yifei Liu</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Byrum, Stephanie D" sort="Byrum, Stephanie D" uniqKey="Byrum S" first="Stephanie D" last="Byrum">Stephanie D. Byrum</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mackintosh, Samuel G" sort="Mackintosh, Samuel G" uniqKey="Mackintosh S" first="Samuel G" last="Mackintosh">Samuel G. Mackintosh</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhong, Mei" sort="Zhong, Mei" uniqKey="Zhong M" first="Mei" last="Zhong">Mei Zhong</name>
<affiliation><nlm:affiliation>Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tackett, Alan" sort="Tackett, Alan" uniqKey="Tackett A" first="Alan" last="Tackett">Alan Tackett</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Guilin" sort="Wang, Guilin" uniqKey="Wang G" first="Guilin" last="Wang">Guilin Wang</name>
<affiliation><nlm:affiliation>Department of Molecular Biophysics &Biochemistry, Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hon, Lawrence S" sort="Hon, Lawrence S" uniqKey="Hon L" first="Lawrence S" last="Hon">Lawrence S. Hon</name>
<affiliation><nlm:affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fang, Gang" sort="Fang, Gang" uniqKey="Fang G" first="Gang" last="Fang">Gang Fang</name>
<affiliation><nlm:affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Swenberg, James A" sort="Swenberg, James A" uniqKey="Swenberg J" first="James A" last="Swenberg">James A. Swenberg</name>
<affiliation><nlm:affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xiao, Andrew Z" sort="Xiao, Andrew Z" uniqKey="Xiao A" first="Andrew Z" last="Xiao">Andrew Z. Xiao</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27027282</idno>
<idno type="pmid">27027282</idno>
<idno type="doi">10.1038/nature17640</idno>
<idno type="pmc">PMC4977844</idno>
<idno type="wicri:Area/Main/Corpus">000C58</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C58</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">DNA methylation on N(6)-adenine in mammalian embryonic stem cells.</title>
<author><name sortKey="Wu, Tao P" sort="Wu, Tao P" uniqKey="Wu T" first="Tao P" last="Wu">Tao P. Wu</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Seetin, Matthew G" sort="Seetin, Matthew G" uniqKey="Seetin M" first="Matthew G" last="Seetin">Matthew G. Seetin</name>
<affiliation><nlm:affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lai, Yongquan" sort="Lai, Yongquan" uniqKey="Lai Y" first="Yongquan" last="Lai">Yongquan Lai</name>
<affiliation><nlm:affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhu, Shijia" sort="Zhu, Shijia" uniqKey="Zhu S" first="Shijia" last="Zhu">Shijia Zhu</name>
<affiliation><nlm:affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lin, Kaixuan" sort="Lin, Kaixuan" uniqKey="Lin K" first="Kaixuan" last="Lin">Kaixuan Lin</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yifei" sort="Liu, Yifei" uniqKey="Liu Y" first="Yifei" last="Liu">Yifei Liu</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Byrum, Stephanie D" sort="Byrum, Stephanie D" uniqKey="Byrum S" first="Stephanie D" last="Byrum">Stephanie D. Byrum</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mackintosh, Samuel G" sort="Mackintosh, Samuel G" uniqKey="Mackintosh S" first="Samuel G" last="Mackintosh">Samuel G. Mackintosh</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhong, Mei" sort="Zhong, Mei" uniqKey="Zhong M" first="Mei" last="Zhong">Mei Zhong</name>
<affiliation><nlm:affiliation>Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tackett, Alan" sort="Tackett, Alan" uniqKey="Tackett A" first="Alan" last="Tackett">Alan Tackett</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Guilin" sort="Wang, Guilin" uniqKey="Wang G" first="Guilin" last="Wang">Guilin Wang</name>
<affiliation><nlm:affiliation>Department of Molecular Biophysics &Biochemistry, Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hon, Lawrence S" sort="Hon, Lawrence S" uniqKey="Hon L" first="Lawrence S" last="Hon">Lawrence S. Hon</name>
<affiliation><nlm:affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fang, Gang" sort="Fang, Gang" uniqKey="Fang G" first="Gang" last="Fang">Gang Fang</name>
<affiliation><nlm:affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Swenberg, James A" sort="Swenberg, James A" uniqKey="Swenberg J" first="James A" last="Swenberg">James A. Swenberg</name>
<affiliation><nlm:affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xiao, Andrew Z" sort="Xiao, Andrew Z" uniqKey="Xiao A" first="Andrew Z" last="Xiao">Andrew Z. Xiao</name>
<affiliation><nlm:affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenine (analogs & derivatives)</term>
<term>Adenine (metabolism)</term>
<term>AlkB Homolog 1, Histone H2a Dioxygenase (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Cell Differentiation (genetics)</term>
<term>DNA Methylation (MeSH)</term>
<term>DNA Transposable Elements (genetics)</term>
<term>DNA-(Apurinic or Apyrimidinic Site) Lyase (deficiency)</term>
<term>DNA-(Apurinic or Apyrimidinic Site) Lyase (genetics)</term>
<term>DNA-(Apurinic or Apyrimidinic Site) Lyase (metabolism)</term>
<term>Enhancer Elements, Genetic (genetics)</term>
<term>Epigenesis, Genetic (genetics)</term>
<term>Evolution, Molecular (MeSH)</term>
<term>Gene Silencing (MeSH)</term>
<term>Long Interspersed Nucleotide Elements (genetics)</term>
<term>Mammals (genetics)</term>
<term>Mice (MeSH)</term>
<term>Mouse Embryonic Stem Cells (cytology)</term>
<term>Mouse Embryonic Stem Cells (metabolism)</term>
<term>Up-Regulation (genetics)</term>
<term>X Chromosome (genetics)</term>
<term>X Chromosome (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>DNA-(Apurinic or Apyrimidinic Site) Lyase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Transposable Elements</term>
<term>DNA-(Apurinic or Apyrimidinic Site) Lyase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenine</term>
<term>DNA-(Apurinic or Apyrimidinic Site) Lyase</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>AlkB Homolog 1, Histone H2a Dioxygenase</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mouse Embryonic Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Differentiation</term>
<term>Enhancer Elements, Genetic</term>
<term>Epigenesis, Genetic</term>
<term>Long Interspersed Nucleotide Elements</term>
<term>Mammals</term>
<term>Up-Regulation</term>
<term>X Chromosome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mouse Embryonic Stem Cells</term>
<term>X Chromosome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>DNA Methylation</term>
<term>Evolution, Molecular</term>
<term>Gene Silencing</term>
<term>Mice</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N(6)-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N(6)-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched at young (<1.5 million years old) but not old (>6 million years old) L1 elements. The deposition of N(6)-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell differentiation. As young full-length LINE-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also silenced. Thus, N(6)-methyladenine developed a new role in epigenetic silencing in mammalian evolution distinct from its role in gene activation in other organisms. Our results demonstrate that N(6)-methyladenine constitutes a crucial component of the epigenetic regulation repertoire in mammalian genomes. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27027282</PMID>
<DateCompleted><Year>2016</Year>
<Month>05</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>532</Volume>
<Issue>7599</Issue>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>DNA methylation on N(6)-adenine in mammalian embryonic stem cells.</ArticleTitle>
<Pagination><MedlinePgn>329-33</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/nature17640</ELocationID>
<Abstract><AbstractText>It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N(6)-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N(6)-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched at young (<1.5 million years old) but not old (>6 million years old) L1 elements. The deposition of N(6)-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell differentiation. As young full-length LINE-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also silenced. Thus, N(6)-methyladenine developed a new role in epigenetic silencing in mammalian evolution distinct from its role in gene activation in other organisms. Our results demonstrate that N(6)-methyladenine constitutes a crucial component of the epigenetic regulation repertoire in mammalian genomes. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Tao P</ForeName>
<Initials>TP</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seetin</LastName>
<ForeName>Matthew G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lai</LastName>
<ForeName>Yongquan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Shijia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Kaixuan</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yifei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Byrum</LastName>
<ForeName>Stephanie D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mackintosh</LastName>
<ForeName>Samuel G</ForeName>
<Initials>SG</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Mei</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tackett</LastName>
<ForeName>Alan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Guilin</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biophysics &Biochemistry, Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hon</LastName>
<ForeName>Lawrence S</ForeName>
<Initials>LS</Initials>
<AffiliationInfo><Affiliation>Pacific Biosciences, 1380 Willow Road, Menlo Park, California 94025, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fang</LastName>
<ForeName>Gang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Swenberg</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Environmental Sciences &Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Andrew Z</ForeName>
<Initials>AZ</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 ES010126</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01GM106024</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM106024</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM114472</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 TR001863</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM114205</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P20 GM103429</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM114472-01</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01GM114205-01</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10OD018445</GrantID>
<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P20GM103429</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 CA016359</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10 OD018445</GrantID>
<Acronym>OD</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P42 ES005948</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>03</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nature</MedlineTA>
<NlmUniqueID>0410462</NlmUniqueID>
<ISSNLinking>0028-0836</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004251">DNA Transposable Elements</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.11.33</RegistryNumber>
<NameOfSubstance UI="D000071498">AlkB Homolog 1, Histone H2a Dioxygenase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.11.33</RegistryNumber>
<NameOfSubstance UI="C529511">Alkbh1 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 4.2.99.18</RegistryNumber>
<NameOfSubstance UI="D043603">DNA-(Apurinic or Apyrimidinic Site) Lyase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>JAC85A2161</RegistryNumber>
<NameOfSubstance UI="D000225">Adenine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>W7IBY2BGAX</RegistryNumber>
<NameOfSubstance UI="C005955">6-methyladenine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nature. 2016 Apr 21;532(7599):319-20</RefSource>
<PMID Version="1">27027294</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000225" MajorTopicYN="N">Adenine</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071498" MajorTopicYN="N">AlkB Homolog 1, Histone H2a Dioxygenase</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019175" MajorTopicYN="Y">DNA Methylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004251" MajorTopicYN="N">DNA Transposable Elements</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D043603" MajorTopicYN="N">DNA-(Apurinic or Apyrimidinic Site) Lyase</DescriptorName>
<QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004742" MajorTopicYN="N">Enhancer Elements, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044127" MajorTopicYN="N">Epigenesis, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020868" MajorTopicYN="N">Gene Silencing</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020084" MajorTopicYN="N">Long Interspersed Nucleotide Elements</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008322" MajorTopicYN="N">Mammals</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000066450" MajorTopicYN="N">Mouse Embryonic Stem Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014960" MajorTopicYN="N">X Chromosome</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>08</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>03</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>3</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>3</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>5</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27027282</ArticleId>
<ArticleId IdType="pii">nature17640</ArticleId>
<ArticleId IdType="doi">10.1038/nature17640</ArticleId>
<ArticleId IdType="pmc">PMC4977844</ArticleId>
<ArticleId IdType="mid">NIHMS805688</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Stem Cells. 2012 Dec;30(12 ):2672-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22961808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 May 7;161(4):893-906</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25936838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 May 7;161(4):710-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25936836</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 May 7;161(4):879-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25936837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Sep 2;431(7004):96-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15318244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2016 Jan 15;351(6270):282-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26816380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 2014;83:585-614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24905787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2013;977:273-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23436370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2011 Mar 15;27(6):870-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21325299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2007 Jun 15;21(12):1519-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17575053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicol Sci. 2010 Aug;116(2):441-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20176625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6634-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10841562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2004 Feb;5(2):148-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15040447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2009 May 1;25(9):1105-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19289445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2013 Mar;14(3):204-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23400093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1983 Jul 25;158(2):353-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6409666</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cytogenet Cell Genet. 1998;80(1-4):133-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9678347</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2013 Mar;20(3):332-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23353788</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Dec;85(23):12315-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21957310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Microbiol. 2013 Apr;16(2):192-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23434113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Cell. 2010 Nov 16;19(5):662-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21074717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2013 Nov;41(20):e195</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24030711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2010 Jun 11;141(6):956-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20550932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2001 Oct;11(10):1677-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11591644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Methods. 2010 Jun;7(6):461-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20453866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2009;10(3):R25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19261174</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Proteome Res. 2005 Sep-Oct;4(5):1752-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16212429</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2014 Jul 1;28(13):1397-409</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24939876</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2009 Aug 1;25(15):1952-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19505939</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Stem Cell. 2014 Sep 4;15(3):281-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25192463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2006 May 29;580(13):3179-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16684535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2016 Jan;23(1):24-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26689968</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 May 7;161(4):868-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25936839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Dev Biol. 2011;55(10-12):909-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22252487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010 Nov 03;5(11):e13827</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21072209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2012 Mar 01;7(3):562-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22383036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Jun 25;8(6):e67403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23825659</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Biotechnol. 2012 Dec;30(12):1232-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23138224</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2008 Aug 29;4(8):e1000172</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18769724</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2008 Oct 3;135(1):23-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18854152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Jan 15;517(7534):321-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25592537</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/WillowV1/Data/Main/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C58 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C58 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    WillowV1
   |flux=    Main
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:27027282
   |texte=   DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i   -Sk "pubmed:27027282" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a WillowV1

This area was generated with Dilib version V0.6.37.
Data generation: Tue Nov 17 16:35:40 2020. Site generation: Tue Nov 17 16:39:32 2020

	Serveur d'exploration sur le saule
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le saule

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki