Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death.
Identifieur interne : 000C47 ( Main/Corpus ); précédent : 000C46; suivant : 000C48Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death.
Auteurs : Donna Papsun ; Alison Krywanczyk ; James C. Vose ; Elizabeth A. Bundock ; Barry K. LoganSource :
- Journal of analytical toxicology [ 1945-2403 ] ; 2016.
English descriptors
- KwdEn :
- Adult (MeSH), Analgesics, Opioid (blood), Analgesics, Opioid (poisoning), Chromatography, High Pressure Liquid (MeSH), Designer Drugs (poisoning), Diazepam (analogs & derivatives), Diazepam (poisoning), Fatal Outcome (MeSH), Humans (MeSH), Male (MeSH), Piperazines (blood), Piperazines (poisoning), Reproducibility of Results (MeSH), Tandem Mass Spectrometry (MeSH).
- MESH :
- chemical , analogs & derivatives : Diazepam.
- chemical , blood : Analgesics, Opioid, Piperazines.
- chemical , poisoning : Analgesics, Opioid, Designer Drugs, Diazepam, Piperazines.
- Adult, Chromatography, High Pressure Liquid, Fatal Outcome, Humans, Male, Reproducibility of Results, Tandem Mass Spectrometry.
Abstract
MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) is just one of the many novel psychoactive substances (NPS) to have reached the recreational drug market in the twenty-first century; it is however, one of the first designer opioids to achieve some degree of popularity, in a market currently dominated by synthetic cannabinoids and designer stimulants. A single fatality involving MT-45 and etizolam is described. A method for the quantitation of MT-45 in whole blood using liquid chromatography-tandem mass spectrometry was developed and validated. The linear range was determined to be 1.0-100 ng/mL with a detection limit of 1.0 ng/mL, and the method met the requirements for acceptable linearity, precision and accuracy. After analyzing the sample on dilution and by standard addition, the concentration of MT-45 in the decedent's blood was determined to be 520 ng/mL, consistent with other concentrations of MT-45 reported in drug-related fatalities. Etizolam was present at a concentration of 35 ng/mL. This case illustrates the importance of considering non-traditional drugs in unexplained apparent drug-related deaths.
DOI: 10.1093/jat/bkw012
PubMed: 27091064
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death.</title><author><name sortKey="Papsun, Donna" sort="Papsun, Donna" uniqKey="Papsun D" first="Donna" last="Papsun">Donna Papsun</name><affiliation><nlm:affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Krywanczyk, Alison" sort="Krywanczyk, Alison" uniqKey="Krywanczyk A" first="Alison" last="Krywanczyk">Alison Krywanczyk</name><affiliation><nlm:affiliation>Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vose, James C" sort="Vose, James C" uniqKey="Vose J" first="James C" last="Vose">James C. Vose</name><affiliation><nlm:affiliation>Vermont Forensic Laboratory, P.O. Box 47, Waterbury, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bundock, Elizabeth A" sort="Bundock, Elizabeth A" uniqKey="Bundock E" first="Elizabeth A" last="Bundock">Elizabeth A. Bundock</name><affiliation><nlm:affiliation>Office of the Chief Medical Examiner, 111 Colchester Avenue, Burlington, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name><affiliation><nlm:affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA The Center for Forensic Science Research and Education (CFSRE), 2300 Welsh Rd, Willow Grove, PA, USA barry.logan@nmslabs.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27091064</idno><idno type="pmid">27091064</idno><idno type="doi">10.1093/jat/bkw012</idno><idno type="wicri:Area/Main/Corpus">000C47</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death.</title><author><name sortKey="Papsun, Donna" sort="Papsun, Donna" uniqKey="Papsun D" first="Donna" last="Papsun">Donna Papsun</name><affiliation><nlm:affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Krywanczyk, Alison" sort="Krywanczyk, Alison" uniqKey="Krywanczyk A" first="Alison" last="Krywanczyk">Alison Krywanczyk</name><affiliation><nlm:affiliation>Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vose, James C" sort="Vose, James C" uniqKey="Vose J" first="James C" last="Vose">James C. Vose</name><affiliation><nlm:affiliation>Vermont Forensic Laboratory, P.O. Box 47, Waterbury, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bundock, Elizabeth A" sort="Bundock, Elizabeth A" uniqKey="Bundock E" first="Elizabeth A" last="Bundock">Elizabeth A. Bundock</name><affiliation><nlm:affiliation>Office of the Chief Medical Examiner, 111 Colchester Avenue, Burlington, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name><affiliation><nlm:affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA The Center for Forensic Science Research and Education (CFSRE), 2300 Welsh Rd, Willow Grove, PA, USA barry.logan@nmslabs.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of analytical toxicology</title><idno type="eISSN">1945-2403</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Analgesics, Opioid (blood)</term><term>Analgesics, Opioid (poisoning)</term><term>Chromatography, High Pressure Liquid (MeSH)</term><term>Designer Drugs (poisoning)</term><term>Diazepam (analogs & derivatives)</term><term>Diazepam (poisoning)</term><term>Fatal Outcome (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Piperazines (blood)</term><term>Piperazines (poisoning)</term><term>Reproducibility of Results (MeSH)</term><term>Tandem Mass Spectrometry (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Diazepam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Analgesics, Opioid</term><term>Piperazines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="poisoning" xml:lang="en"><term>Analgesics, Opioid</term><term>Designer Drugs</term><term>Diazepam</term><term>Piperazines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Chromatography, High Pressure Liquid</term><term>Fatal Outcome</term><term>Humans</term><term>Male</term><term>Reproducibility of Results</term><term>Tandem Mass Spectrometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) is just one of the many novel psychoactive substances (NPS) to have reached the recreational drug market in the twenty-first century; it is however, one of the first designer opioids to achieve some degree of popularity, in a market currently dominated by synthetic cannabinoids and designer stimulants. A single fatality involving MT-45 and etizolam is described. A method for the quantitation of MT-45 in whole blood using liquid chromatography-tandem mass spectrometry was developed and validated. The linear range was determined to be 1.0-100 ng/mL with a detection limit of 1.0 ng/mL, and the method met the requirements for acceptable linearity, precision and accuracy. After analyzing the sample on dilution and by standard addition, the concentration of MT-45 in the decedent's blood was determined to be 520 ng/mL, consistent with other concentrations of MT-45 reported in drug-related fatalities. Etizolam was present at a concentration of 35 ng/mL. This case illustrates the importance of considering non-traditional drugs in unexplained apparent drug-related deaths. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27091064</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1945-2403</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of analytical toxicology</Title><ISOAbbreviation>J Anal Toxicol</ISOAbbreviation></Journal><ArticleTitle>Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death.</ArticleTitle><Pagination><MedlinePgn>313-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jat/bkw012</ELocationID><Abstract><AbstractText>MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) is just one of the many novel psychoactive substances (NPS) to have reached the recreational drug market in the twenty-first century; it is however, one of the first designer opioids to achieve some degree of popularity, in a market currently dominated by synthetic cannabinoids and designer stimulants. A single fatality involving MT-45 and etizolam is described. A method for the quantitation of MT-45 in whole blood using liquid chromatography-tandem mass spectrometry was developed and validated. The linear range was determined to be 1.0-100 ng/mL with a detection limit of 1.0 ng/mL, and the method met the requirements for acceptable linearity, precision and accuracy. After analyzing the sample on dilution and by standard addition, the concentration of MT-45 in the decedent's blood was determined to be 520 ng/mL, consistent with other concentrations of MT-45 reported in drug-related fatalities. Etizolam was present at a concentration of 35 ng/mL. This case illustrates the importance of considering non-traditional drugs in unexplained apparent drug-related deaths. </AbstractText><CopyrightInformation>© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Papsun</LastName><ForeName>Donna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krywanczyk</LastName><ForeName>Alison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vose</LastName><ForeName>James C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Vermont Forensic Laboratory, P.O. Box 47, Waterbury, VT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bundock</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Office of the Chief Medical Examiner, 111 Colchester Avenue, Burlington, VT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Logan</LastName><ForeName>Barry K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>NMS Labs, 2300 Welsh Rd, Willow Grove, PA, USA The Center for Forensic Science Research and Education (CFSRE), 2300 Welsh Rd, Willow Grove, PA, USA barry.logan@nmslabs.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Anal Toxicol</MedlineTA><NlmUniqueID>7705085</NlmUniqueID><ISSNLinking>0146-4760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000701">Analgesics, Opioid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015198">Designer Drugs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010879">Piperazines</NameOfSubstance></Chemical><Chemical><RegistryNumber>52694-55-0</RegistryNumber><NameOfSubstance UI="C012631">(+,-)-1-cyclohexyl-4-(1,2-diphenylethyl)piperazine</NameOfSubstance></Chemical><Chemical><RegistryNumber>A76XI0HL37</RegistryNumber><NameOfSubstance UI="C044610">etizolam</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q3JTX2Q7TU</RegistryNumber><NameOfSubstance UI="D003975">Diazepam</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000701" MajorTopicYN="N">Analgesics, Opioid</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000506" MajorTopicYN="Y">poisoning</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015198" MajorTopicYN="N">Designer Drugs</DescriptorName><QualifierName UI="Q000506" MajorTopicYN="N">poisoning</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003975" MajorTopicYN="N">Diazepam</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000506" MajorTopicYN="N">poisoning</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010879" MajorTopicYN="N">Piperazines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000506" MajorTopicYN="Y">poisoning</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053719" MajorTopicYN="N">Tandem Mass Spectrometry</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27091064</ArticleId><ArticleId IdType="pii">bkw012</ArticleId><ArticleId IdType="doi">10.1093/jat/bkw012</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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