4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework.
Identifieur interne : 000423 ( Main/Corpus ); précédent : 000422; suivant : 0004244F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework.
Auteurs : Alex J. Krotulski ; Amanda L A. Mohr ; Sherri L. Kacinko ; Melissa F. Fogarty ; Sarah A. Shuda ; Francis X. Diamond ; William A. Kinney ; M J Menendez ; Barry K. LoganSource :
- Journal of forensic sciences [ 1556-4029 ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Cannabinoids, Illicit Drugs, Synthetic Drugs.
- Gas Chromatography-Mass Spectrometry, Humans, Magnetic Resonance Spectroscopy, Molecular Structure.
Abstract
This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA. 4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, 4F-MDMB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal death investigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimens resulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laboratories must be aware of its presence and impact, incorporating 4F-MDMB-BINACA into workflows for detection and confirmation.
DOI: 10.1111/1556-4029.14101
PubMed: 31260580
Links to Exploration step
pubmed:31260580Le document en format XML
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Kacinko</name><affiliation><nlm:affiliation>NMS Labs, 200 Welsh Road, Horsham, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Fogarty, Melissa F" sort="Fogarty, Melissa F" uniqKey="Fogarty M" first="Melissa F" last="Fogarty">Melissa F. Fogarty</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Shuda, Sarah A" sort="Shuda, Sarah A" uniqKey="Shuda S" first="Sarah A" last="Shuda">Sarah A. Shuda</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Diamond, Francis X" sort="Diamond, Francis X" uniqKey="Diamond F" first="Francis X" last="Diamond">Francis X. Diamond</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Kinney, William A" sort="Kinney, William A" uniqKey="Kinney W" first="William A" last="Kinney">William A. Kinney</name><affiliation><nlm:affiliation>IteraMed Consulting LLC, 3805 Old Easton Road, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Menendez, M J" sort="Menendez, M J" uniqKey="Menendez M" first="M J" last="Menendez">M J Menendez</name><affiliation><nlm:affiliation>Organized Crime Drug Enforcement Task Force (OCDETF), U.S. Department of Justice, 950 Pennsylvania Avenue NW, Washington, DC.</nlm:affiliation></affiliation></author><author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. 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Krotulski</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Mohr, Amanda L A" sort="Mohr, Amanda L A" uniqKey="Mohr A" first="Amanda L A" last="Mohr">Amanda L A. Mohr</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Kacinko, Sherri L" sort="Kacinko, Sherri L" uniqKey="Kacinko S" first="Sherri L" last="Kacinko">Sherri L. Kacinko</name><affiliation><nlm:affiliation>NMS Labs, 200 Welsh Road, Horsham, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Fogarty, Melissa F" sort="Fogarty, Melissa F" uniqKey="Fogarty M" first="Melissa F" last="Fogarty">Melissa F. Fogarty</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Shuda, Sarah A" sort="Shuda, Sarah A" uniqKey="Shuda S" first="Sarah A" last="Shuda">Sarah A. Shuda</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Diamond, Francis X" sort="Diamond, Francis X" uniqKey="Diamond F" first="Francis X" last="Diamond">Francis X. Diamond</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Kinney, William A" sort="Kinney, William A" uniqKey="Kinney W" first="William A" last="Kinney">William A. Kinney</name><affiliation><nlm:affiliation>IteraMed Consulting LLC, 3805 Old Easton Road, Doylestown, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Menendez, M J" sort="Menendez, M J" uniqKey="Menendez M" first="M J" last="Menendez">M J Menendez</name><affiliation><nlm:affiliation>Organized Crime Drug Enforcement Task Force (OCDETF), U.S. Department of Justice, 950 Pennsylvania Avenue NW, Washington, DC.</nlm:affiliation></affiliation></author><author><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name><affiliation><nlm:affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of forensic sciences</title><idno type="eISSN">1556-4029</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cannabinoids (chemistry)</term><term>Gas Chromatography-Mass Spectrometry (MeSH)</term><term>Humans (MeSH)</term><term>Illicit Drugs (chemistry)</term><term>Magnetic Resonance Spectroscopy (MeSH)</term><term>Molecular Structure (MeSH)</term><term>Synthetic Drugs (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cannabinoids</term><term>Illicit Drugs</term><term>Synthetic Drugs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gas Chromatography-Mass Spectrometry</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Molecular Structure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA. 4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, 4F-MDMB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal death investigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimens resulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laboratories must be aware of its presence and impact, incorporating 4F-MDMB-BINACA into workflows for detection and confirmation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31260580</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1556-4029</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of forensic sciences</Title><ISOAbbreviation>J Forensic Sci</ISOAbbreviation></Journal><ArticleTitle>4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework.</ArticleTitle><Pagination><MedlinePgn>1451-1461</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/1556-4029.14101</ELocationID><Abstract><AbstractText>This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA. 4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characterization, 4F-MDMB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal death investigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimens resulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laboratories must be aware of its presence and impact, incorporating 4F-MDMB-BINACA into workflows for detection and confirmation.</AbstractText><CopyrightInformation>© 2019 American Academy of Forensic Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krotulski</LastName><ForeName>Alex J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1775-1882</Identifier><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohr</LastName><ForeName>Amanda L A</ForeName><Initials>ALA</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kacinko</LastName><ForeName>Sherri L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>NMS Labs, 200 Welsh Road, Horsham, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fogarty</LastName><ForeName>Melissa F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shuda</LastName><ForeName>Sarah A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diamond</LastName><ForeName>Francis X</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kinney</LastName><ForeName>William A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>IteraMed Consulting LLC, 3805 Old Easton Road, Doylestown, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menendez</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Organized Crime Drug Enforcement Task Force (OCDETF), U.S. Department of Justice, 950 Pennsylvania Avenue NW, Washington, DC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Logan</LastName><ForeName>Barry K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation, 2300 Stratford Avenue, Willow Grove, PA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>Award Number 2017-R2-CX-0021</GrantID><Agency>National Institute of Justice</Agency><Country></Country></Grant><Grant><Acronym>CC</Acronym><Agency>CDC HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Forensic Sci</MedlineTA><NlmUniqueID>0375370</NlmUniqueID><ISSNLinking>0022-1198</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002186">Cannabinoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013287">Illicit Drugs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000076742">Synthetic Drugs</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002186" MajorTopicYN="N">Cannabinoids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013287" MajorTopicYN="N">Illicit Drugs</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076742" MajorTopicYN="N">Synthetic Drugs</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">4F-MDMB-BINACA</Keyword><Keyword MajorTopicYN="N">NPS</Keyword><Keyword MajorTopicYN="N">forensic chemistry</Keyword><Keyword MajorTopicYN="N">forensic science</Keyword><Keyword MajorTopicYN="N">forensic toxicology</Keyword><Keyword MajorTopicYN="N">gas chromatography</Keyword><Keyword MajorTopicYN="N">liquid chromatography</Keyword><Keyword MajorTopicYN="N">mass spectrometry</Keyword><Keyword MajorTopicYN="N">metabolism</Keyword><Keyword MajorTopicYN="N">novel psychoactive substance</Keyword><Keyword MajorTopicYN="N">quadrupole time-of-flight mass spectrometry</Keyword><Keyword MajorTopicYN="N">seized drug</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>04</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>05</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31260580</ArticleId><ArticleId IdType="doi">10.1111/1556-4029.14101</ArticleId></ArticleIdList><ReferenceList><Title>References</Title><Reference><Citation>Presley BC, Jansen-Varnum SA, Logan BK. 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