Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn's disease.
Identifieur interne : 000414 ( Main/Corpus ); précédent : 000413; suivant : 000415Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn's disease.
Auteurs : Yin Shi ; Yajing Guo ; Jing Zhou ; Luyi Wu ; Liu Chen ; Yi Sun ; Tao Li ; Jimeng Zhao ; Chunhui Bao ; Huangan WuSource :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 1950-6007 ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Artemisia (chemistry), Colon (metabolism), Colon (ultrastructure), Crohn Disease (metabolism), Crohn Disease (pathology), Crohn Disease (therapy), Disease Models, Animal (MeSH), Epithelial Cells (metabolism), Epithelial Cells (pathology), Intestinal Mucosa (metabolism), Intestinal Mucosa (ultrastructure), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Moxibustion (methods), Permeability (MeSH), Tight Junctions (metabolism), Tight Junctions (ultrastructure), Tumor Necrosis Factor alpha-Induced Protein 3 (genetics), Tumor Necrosis Factor alpha-Induced Protein 3 (metabolism), Up-Regulation (MeSH).
- MESH :
- chemical , genetics : Tumor Necrosis Factor alpha-Induced Protein 3.
- chemistry : Artemisia.
- metabolism : Colon, Crohn Disease, Epithelial Cells, Intestinal Mucosa, Tight Junctions, Tumor Necrosis Factor alpha-Induced Protein 3.
- methods : Moxibustion.
- pathology : Crohn Disease, Epithelial Cells.
- therapy : Crohn Disease.
- ultrastructure : Colon, Intestinal Mucosa, Tight Junctions.
- Animals, Disease Models, Animal, Mice, Inbred C57BL, Mice, Knockout, Permeability, Up-Regulation.
Abstract
BACKGROUND
To investigate effects moxibustion exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Crohn's disease (CD).
METHODS
C57BL/6 wild type (WT) and A20
RESULTS
Intestinal epithelial ultrastructure of WT HPM mice improved more than A20
CONCLUSION
HPM downregulates abnormal activation of the TNF-α-NF-κB-MLCK pathway by upregulating expression of A20 in a mouse model of CD, thereby protecting intestinal epithelial tight junctions and repairing the damage CD causes to the intestinal epithelial barrier.
DOI: 10.1016/j.biopha.2019.109149
PubMed: 31302421
Links to Exploration step
pubmed:31302421Le document en format XML
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Electronic address: guoyajing0817@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Jing" sort="Zhou, Jing" uniqKey="Zhou J" first="Jing" last="Zhou">Jing Zhou</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 419045934@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Luyi" sort="Wu, Luyi" uniqKey="Wu L" first="Luyi" last="Wu">Luyi Wu</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Qigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China. 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Electronic address: baochunhui789@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Huangan" sort="Wu, Huangan" uniqKey="Wu H" first="Huangan" last="Wu">Huangan Wu</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: wuhuangan@126.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31302421</idno><idno type="pmid">31302421</idno><idno type="doi">10.1016/j.biopha.2019.109149</idno><idno type="wicri:Area/Main/Corpus">000414</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000414</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn's disease.</title><author><name sortKey="Shi, Yin" sort="Shi, Yin" uniqKey="Shi Y" first="Yin" last="Shi">Yin Shi</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: flysy0636@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Yajing" sort="Guo, Yajing" uniqKey="Guo Y" first="Yajing" last="Guo">Yajing Guo</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: guoyajing0817@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Jing" sort="Zhou, Jing" uniqKey="Zhou J" first="Jing" last="Zhou">Jing Zhou</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 419045934@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Luyi" sort="Wu, Luyi" uniqKey="Wu L" first="Luyi" last="Wu">Luyi Wu</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Qigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China. Electronic address: luyitcm@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Liu" sort="Chen, Liu" uniqKey="Chen L" first="Liu" last="Chen">Liu Chen</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: willow_chen0913@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 1025830709@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation><nlm:affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 1277713209@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jimeng" sort="Zhao, Jimeng" uniqKey="Zhao J" first="Jimeng" last="Zhao">Jimeng Zhao</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: zhaojm0414@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Chunhui" sort="Bao, Chunhui" uniqKey="Bao C" first="Chunhui" last="Bao">Chunhui Bao</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: baochunhui789@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Huangan" sort="Wu, Huangan" uniqKey="Wu H" first="Huangan" last="Wu">Huangan Wu</name><affiliation><nlm:affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: wuhuangan@126.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</title><idno type="eISSN">1950-6007</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Artemisia (chemistry)</term><term>Colon (metabolism)</term><term>Colon (ultrastructure)</term><term>Crohn Disease (metabolism)</term><term>Crohn Disease (pathology)</term><term>Crohn Disease (therapy)</term><term>Disease Models, Animal (MeSH)</term><term>Epithelial Cells (metabolism)</term><term>Epithelial Cells (pathology)</term><term>Intestinal Mucosa (metabolism)</term><term>Intestinal Mucosa (ultrastructure)</term><term>Mice, Inbred C57BL (MeSH)</term><term>Mice, Knockout (MeSH)</term><term>Moxibustion (methods)</term><term>Permeability (MeSH)</term><term>Tight Junctions (metabolism)</term><term>Tight Junctions (ultrastructure)</term><term>Tumor Necrosis Factor alpha-Induced Protein 3 (genetics)</term><term>Tumor Necrosis Factor alpha-Induced Protein 3 (metabolism)</term><term>Up-Regulation (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Tumor Necrosis Factor alpha-Induced Protein 3</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Artemisia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colon</term><term>Crohn Disease</term><term>Epithelial Cells</term><term>Intestinal Mucosa</term><term>Tight Junctions</term><term>Tumor Necrosis Factor alpha-Induced Protein 3</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Moxibustion</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Crohn Disease</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Crohn Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Colon</term><term>Intestinal Mucosa</term><term>Tight Junctions</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Permeability</term><term>Up-Regulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>To investigate effects moxibustion exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Crohn's disease (CD).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>C57BL/6 wild type (WT) and A20</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Intestinal epithelial ultrastructure of WT HPM mice improved more than A20</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>HPM downregulates abnormal activation of the TNF-α-NF-κB-MLCK pathway by upregulating expression of A20 in a mouse model of CD, thereby protecting intestinal epithelial tight junctions and repairing the damage CD causes to the intestinal epithelial barrier.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31302421</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1950-6007</ISSN><JournalIssue CitedMedium="Internet"><Volume>118</Volume><PubDate><Year>2019</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</Title><ISOAbbreviation>Biomed Pharmacother</ISOAbbreviation></Journal><ArticleTitle>Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn's disease.</ArticleTitle><Pagination><MedlinePgn>109149</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0753-3322(19)32075-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopha.2019.109149</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To investigate effects moxibustion exerts on A20 expression and regulation of intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Crohn's disease (CD).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">C57BL/6 wild type (WT) and A20<sup>IEC-KO</sup> mice (48 each) were randomly divided into normal control (NC), model control (MC), mesalazine (MESA) and herbs-partitioned moxibustion (HPM) groups (12 mice per group). An experimental model of CD was established using 2, 4, 6 trinitrobenzene sulfonic acid. MESA and HPM mice were treated with MESA and HPM (at Tianshu (ST25) and Qihai (CV6)), respectively. In HPM group, moxa cones (0.5 cm in diameter and 0.3 cm in height) made of refined mugwort floss were placed on herbal cakes (medicinal formula dispensing [radix] Aconiti praeparata, [cortex] Cinnamomi, etc.) at Tianshu (ST25) and Qihai (CV6) and ignited. The moxa cones were ignited, and two moxa cones were used for each treatment once daily for 10 days. In MESA group, mice were fed MESA, which was prepared at a proportion of 1:0.0026, twice daily for 10 days.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Intestinal epithelial ultrastructure of WT HPM mice improved more than A20<sup>IEC-KO</sup> HPM mice compared to MC mice. WT HPM mice exhibited greater expression of A20 compared with MC mice (P < 0.01). TNF-α, NF-kB p65, MLCK, MLC, TRAF6 and RIP1 levels in A20<sup>IEC-KO</sup> and WT HPM mice were all decreased compared to MC mice (P<sub>all</sub> < 0.01). NF-κB p65、MLCK and TRAF6 levels were increased in A20<sup>IEC-KO</sup> HPM mice as compared to WT HPM mice (P<sub>all</sub> < 0.05). Intestinal epithelial levels of occludin, claudin-1, ZO-1 and F-actin increased in all HPM mice (P<sub>all</sub> < 0.01-0.05), while occludin, claudin-1, and ZO-1 levels were lower in A20 <sup>IEC-KO</sup> HPM mice (P < 0.05, P < 0.01, P < 0.01).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">HPM downregulates abnormal activation of the TNF-α-NF-κB-MLCK pathway by upregulating expression of A20 in a mouse model of CD, thereby protecting intestinal epithelial tight junctions and repairing the damage CD causes to the intestinal epithelial barrier.</AbstractText><CopyrightInformation>Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Yin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Outpatient Department, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: flysy0636@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Yajing</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: guoyajing0817@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 419045934@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Luyi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Qigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China. Electronic address: luyitcm@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Liu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: willow_chen0913@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 1025830709@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 1277713209@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jimeng</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: zhaojm0414@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Chunhui</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: baochunhui789@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Huangan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, China. Electronic address: wuhuangan@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biomed Pharmacother</MedlineTA><NlmUniqueID>8213295</NlmUniqueID><ISSNLinking>0753-3322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.4.19.12</RegistryNumber><NameOfSubstance UI="D000072598">Tumor Necrosis Factor alpha-Induced Protein 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="C513261">Tnfaip3 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019306" MajorTopicYN="N">Artemisia</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003424" MajorTopicYN="N">Crohn Disease</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009071" MajorTopicYN="N">Moxibustion</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010539" MajorTopicYN="N">Permeability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019108" MajorTopicYN="N">Tight Junctions</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000072598" MajorTopicYN="N">Tumor Necrosis Factor alpha-Induced Protein 3</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">A20</Keyword><Keyword MajorTopicYN="N">Crohn’s disease</Keyword><Keyword MajorTopicYN="N">Herbs-partitioned moxibustion</Keyword><Keyword MajorTopicYN="N">Intestinal epithelial barrier</Keyword><Keyword MajorTopicYN="N">TNF-α-NF-κB-MLCK pathway</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>06</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31302421</ArticleId><ArticleId IdType="pii">S0753-3322(19)32075-X</ArticleId><ArticleId IdType="doi">10.1016/j.biopha.2019.109149</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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