Residual symptoms of PTSD following Sertraline plus enhanced medication management, Sertraline plus PE, and PE plus placebo.
Identifieur interne : 000078 ( Main/Corpus ); précédent : 000077; suivant : 000079Residual symptoms of PTSD following Sertraline plus enhanced medication management, Sertraline plus PE, and PE plus placebo.
Auteurs : Jessica C. Tripp ; Sonya B. Norman ; H Myra Kim ; Margaret R. Venners ; Brian Martis ; Naomi M. Simon ; Murray B. Stein ; Carolyn B. Allard ; Sheila A M. RauchSource :
- Psychiatry research [ 1872-7123 ] ; 2020.
Abstract
Although prolonged exposure (PE) and SSRI antidepressants are effective in treating posttraumatic stress disorder (PTSD), previous studies have shown that some symptoms tend to persist. The current study compared sertraline hydrochloride plus enhanced medication management (EMM), PE plus placebo, or PE plus sertraline hydrochloride in the likelihood of each individual PTSD symptom persisting in veterans with a PTSD diagnosis. We compared the likelihood of individual PTSD symptoms persisting in those with versus without a PTSD diagnosis at posttreatment. We found no significant differences across conditions in which symptoms were likely to persist posttreatment. Among those without a PTSD diagnosis at posttreatment, sleeping difficulties (63.0%), hypervigilance (47.3%), and nightmares (45.0%) were most likely to persist. Findings indicate no consistent differences in residual symptoms between PE and medications, and shared decision making with patients is encouraged in selecting treatments. Gold standard treatments (e.g., CBT-I) may be warranted for residual symptoms like insomnia.
DOI: 10.1016/j.psychres.2020.113279
PubMed: 32763541
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Residual symptoms of PTSD following Sertraline plus enhanced medication management, Sertraline plus PE, and PE plus placebo.</title><author><name sortKey="Tripp, Jessica C" sort="Tripp, Jessica C" uniqKey="Tripp J" first="Jessica C" last="Tripp">Jessica C. Tripp</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Sonya B" sort="Norman, Sonya B" uniqKey="Norman S" first="Sonya B" last="Norman">Sonya B. Norman</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA; National Center for PTSD, 215 N. Main St., White River Junction, VT 05009, USA; VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Dr., MC116B, San Diego, CA 92161, USA. Electronic address: snorman@health.ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, H Myra" sort="Kim, H Myra" uniqKey="Kim H" first="H Myra" last="Kim">H Myra Kim</name><affiliation><nlm:affiliation>Consulting for Statistics, Computing and Analytics Research, University of Michigan, 915 E. Washington Street, Ann Arbor, MI 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Venners, Margaret R" sort="Venners, Margaret R" uniqKey="Venners M" first="Margaret R" last="Venners">Margaret R. Venners</name><affiliation><nlm:affiliation>National Center for PTSD, Dissemination & Training Division, 795 Willow Road, Menlo Park, CA 94025, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Martis, Brian" sort="Martis, Brian" uniqKey="Martis B" first="Brian" last="Martis">Brian Martis</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, Naomi M" sort="Simon, Naomi M" uniqKey="Simon N" first="Naomi M" last="Simon">Naomi M. Simon</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, Boston, MA, USA; Department of Psychiatry, New York University Grossman School of Medicine, One Park Avenue 8(th) Floor, New York, NY 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stein, Murray B" sort="Stein, Murray B" uniqKey="Stein M" first="Murray B" last="Stein">Murray B. Stein</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allard, Carolyn B" sort="Allard, Carolyn B" uniqKey="Allard C" first="Carolyn B" last="Allard">Carolyn B. Allard</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; Alliant International University, 10455 Pomerado Road, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rauch, Sheila A M" sort="Rauch, Sheila A M" uniqKey="Rauch S" first="Sheila A M" last="Rauch">Sheila A M. Rauch</name><affiliation><nlm:affiliation>Mental Health Service Line, Veterans Affairs Atlanta Healthcare System, 1670 Clairmont Rd., GA 30030, USA; Emory University School of Medicine, 12 Executive Park, 3(rd) Floor, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32763541</idno><idno type="pmid">32763541</idno><idno type="doi">10.1016/j.psychres.2020.113279</idno><idno type="wicri:Area/Main/Corpus">000078</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Residual symptoms of PTSD following Sertraline plus enhanced medication management, Sertraline plus PE, and PE plus placebo.</title><author><name sortKey="Tripp, Jessica C" sort="Tripp, Jessica C" uniqKey="Tripp J" first="Jessica C" last="Tripp">Jessica C. Tripp</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Sonya B" sort="Norman, Sonya B" uniqKey="Norman S" first="Sonya B" last="Norman">Sonya B. Norman</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA; National Center for PTSD, 215 N. Main St., White River Junction, VT 05009, USA; VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Dr., MC116B, San Diego, CA 92161, USA. Electronic address: snorman@health.ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, H Myra" sort="Kim, H Myra" uniqKey="Kim H" first="H Myra" last="Kim">H Myra Kim</name><affiliation><nlm:affiliation>Consulting for Statistics, Computing and Analytics Research, University of Michigan, 915 E. Washington Street, Ann Arbor, MI 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Venners, Margaret R" sort="Venners, Margaret R" uniqKey="Venners M" first="Margaret R" last="Venners">Margaret R. Venners</name><affiliation><nlm:affiliation>National Center for PTSD, Dissemination & Training Division, 795 Willow Road, Menlo Park, CA 94025, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Martis, Brian" sort="Martis, Brian" uniqKey="Martis B" first="Brian" last="Martis">Brian Martis</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, Naomi M" sort="Simon, Naomi M" uniqKey="Simon N" first="Naomi M" last="Simon">Naomi M. Simon</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, Boston, MA, USA; Department of Psychiatry, New York University Grossman School of Medicine, One Park Avenue 8(th) Floor, New York, NY 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stein, Murray B" sort="Stein, Murray B" uniqKey="Stein M" first="Murray B" last="Stein">Murray B. Stein</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allard, Carolyn B" sort="Allard, Carolyn B" uniqKey="Allard C" first="Carolyn B" last="Allard">Carolyn B. Allard</name><affiliation><nlm:affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; Alliant International University, 10455 Pomerado Road, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rauch, Sheila A M" sort="Rauch, Sheila A M" uniqKey="Rauch S" first="Sheila A M" last="Rauch">Sheila A M. Rauch</name><affiliation><nlm:affiliation>Mental Health Service Line, Veterans Affairs Atlanta Healthcare System, 1670 Clairmont Rd., GA 30030, USA; Emory University School of Medicine, 12 Executive Park, 3(rd) Floor, Atlanta, GA 30329, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although prolonged exposure (PE) and SSRI antidepressants are effective in treating posttraumatic stress disorder (PTSD), previous studies have shown that some symptoms tend to persist. The current study compared sertraline hydrochloride plus enhanced medication management (EMM), PE plus placebo, or PE plus sertraline hydrochloride in the likelihood of each individual PTSD symptom persisting in veterans with a PTSD diagnosis. We compared the likelihood of individual PTSD symptoms persisting in those with versus without a PTSD diagnosis at posttreatment. We found no significant differences across conditions in which symptoms were likely to persist posttreatment. Among those without a PTSD diagnosis at posttreatment, sleeping difficulties (63.0%), hypervigilance (47.3%), and nightmares (45.0%) were most likely to persist. Findings indicate no consistent differences in residual symptoms between PE and medications, and shared decision making with patients is encouraged in selecting treatments. Gold standard treatments (e.g., CBT-I) may be warranted for residual symptoms like insomnia.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32763541</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7123</ISSN><JournalIssue CitedMedium="Internet"><Volume>291</Volume><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Psychiatry research</Title><ISOAbbreviation>Psychiatry Res</ISOAbbreviation></Journal><ArticleTitle>Residual symptoms of PTSD following Sertraline plus enhanced medication management, Sertraline plus PE, and PE plus placebo.</ArticleTitle><Pagination><MedlinePgn>113279</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0165-1781(20)31392-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psychres.2020.113279</ELocationID><Abstract><AbstractText>Although prolonged exposure (PE) and SSRI antidepressants are effective in treating posttraumatic stress disorder (PTSD), previous studies have shown that some symptoms tend to persist. The current study compared sertraline hydrochloride plus enhanced medication management (EMM), PE plus placebo, or PE plus sertraline hydrochloride in the likelihood of each individual PTSD symptom persisting in veterans with a PTSD diagnosis. We compared the likelihood of individual PTSD symptoms persisting in those with versus without a PTSD diagnosis at posttreatment. We found no significant differences across conditions in which symptoms were likely to persist posttreatment. Among those without a PTSD diagnosis at posttreatment, sleeping difficulties (63.0%), hypervigilance (47.3%), and nightmares (45.0%) were most likely to persist. Findings indicate no consistent differences in residual symptoms between PE and medications, and shared decision making with patients is encouraged in selecting treatments. Gold standard treatments (e.g., CBT-I) may be warranted for residual symptoms like insomnia.</AbstractText><CopyrightInformation>Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tripp</LastName><ForeName>Jessica C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norman</LastName><ForeName>Sonya B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA; National Center for PTSD, 215 N. Main St., White River Junction, VT 05009, USA; VA Center of Excellence for Stress and Mental Health, 3350 La Jolla Village Dr., MC116B, San Diego, CA 92161, USA. Electronic address: snorman@health.ucsd.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>H Myra</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Consulting for Statistics, Computing and Analytics Research, University of Michigan, 915 E. Washington Street, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venners</LastName><ForeName>Margaret R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>National Center for PTSD, Dissemination & Training Division, 795 Willow Road, Menlo Park, CA 94025, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martis</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simon</LastName><ForeName>Naomi M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, Boston, MA, USA; Department of Psychiatry, New York University Grossman School of Medicine, One Park Avenue 8(th) Floor, New York, NY 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>Murray B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allard</LastName><ForeName>Carolyn B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; Alliant International University, 10455 Pomerado Road, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rauch</LastName><ForeName>Sheila A M</ForeName><Initials>SAM</Initials><AffiliationInfo><Affiliation>Mental Health Service Line, Veterans Affairs Atlanta Healthcare System, 1670 Clairmont Rd., GA 30030, USA; Emory University School of Medicine, 12 Executive Park, 3(rd) Floor, Atlanta, GA 30329, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>PROGrESS Study Team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Psychiatry Res</MedlineTA><NlmUniqueID>7911385</NlmUniqueID><ISSNLinking>0165-1781</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Posttraumatic stress disorder</Keyword><Keyword MajorTopicYN="Y">Psychopharmacology</Keyword><Keyword MajorTopicYN="Y">Psychotherapy</Keyword><Keyword MajorTopicYN="Y">Residual symptoms</Keyword><Keyword MajorTopicYN="Y">Veterans</Keyword></KeywordList><CoiStatement>Declaration of Competing Interests No other disclosures were reported. For the remaining authors, no conflicts of interest were declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32763541</ArticleId><ArticleId IdType="pii">S0165-1781(20)31392-5</ArticleId><ArticleId IdType="doi">10.1016/j.psychres.2020.113279</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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