Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity.
Identifieur interne : 000047 ( Main/Corpus ); précédent : 000046; suivant : 000048Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity.
Auteurs : Hidetomo Kikuchi ; Nana Toyoda ; Satoko Ezawa ; Shiori Yoshida ; Yasuhide Hibino ; Katsuyoshi SunagaSource :
- Molecular medicine reports [ 1791-3004 ] ; 2020.
Abstract
α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the presence of the α‑glucosidase inhibitory activity in herbs, in which various functional effects have been known to occur, the present study investigated the effects of hot‑water extracts of 26 types of herbs on α‑glucosidase activity in an in vitro assay. The results indicated significant increases in the inhibition of α‑glucosidase activity in 1,000 µg/ml olive (P<0.01), white willow (P<0.01) and red rooibos hot‑water extracts. Furthermore, ≥50% inhibition of α‑glucosidase activity was determined to be significant in 1,000 µg/ml coltsfoot, green tea and bearberry hot‑water extracts. In addition, the effects of bearberry, green tea and coltsfoot hot‑water extracts on α‑glucosidase activity in vivo were evaluated according to the blood glucose levels (BGLs) in maltose and glucose load model rats. It was indicated that the administration of these three herb extracts significantly reduced the increasing BGLs after maltose loading until 0.5 h compared with the control group. However, only coltsfoot extract significantly reduced the increasing BGLs after glucose loading until 0.5 h compared with the control group. Thus, the present results may facilitate the understanding of a novel functionality in traditional herbs, which could be useful for the prevention of disease onset and progression, such as in hyperglycemia and type 2 diabetes.
DOI: 10.3892/mmr.2020.11397
PubMed: 32945423
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first="Satoko" last="Ezawa">Satoko Ezawa</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshida, Shiori" sort="Yoshida, Shiori" uniqKey="Yoshida S" first="Shiori" last="Yoshida">Shiori Yoshida</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hibino, Yasuhide" sort="Hibino, Yasuhide" uniqKey="Hibino Y" first="Yasuhide" last="Hibino">Yasuhide Hibino</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sunaga, Katsuyoshi" sort="Sunaga, Katsuyoshi" uniqKey="Sunaga K" first="Katsuyoshi" last="Sunaga">Katsuyoshi Sunaga</name><affiliation><nlm:affiliation>SunagaLaboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32945423</idno><idno type="pmid">32945423</idno><idno type="doi">10.3892/mmr.2020.11397</idno><idno type="wicri:Area/Main/Corpus">000047</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000047</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity.</title><author><name sortKey="Kikuchi, Hidetomo" sort="Kikuchi, Hidetomo" uniqKey="Kikuchi H" first="Hidetomo" last="Kikuchi">Hidetomo Kikuchi</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Toyoda, Nana" sort="Toyoda, Nana" uniqKey="Toyoda N" first="Nana" last="Toyoda">Nana Toyoda</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ezawa, Satoko" sort="Ezawa, Satoko" uniqKey="Ezawa S" first="Satoko" last="Ezawa">Satoko Ezawa</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshida, Shiori" sort="Yoshida, Shiori" uniqKey="Yoshida S" first="Shiori" last="Yoshida">Shiori Yoshida</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hibino, Yasuhide" sort="Hibino, Yasuhide" uniqKey="Hibino Y" first="Yasuhide" last="Hibino">Yasuhide Hibino</name><affiliation><nlm:affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sunaga, Katsuyoshi" sort="Sunaga, Katsuyoshi" uniqKey="Sunaga K" first="Katsuyoshi" last="Sunaga">Katsuyoshi Sunaga</name><affiliation><nlm:affiliation>SunagaLaboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular medicine reports</title><idno type="eISSN">1791-3004</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the presence of the α‑glucosidase inhibitory activity in herbs, in which various functional effects have been known to occur, the present study investigated the effects of hot‑water extracts of 26 types of herbs on α‑glucosidase activity in an in vitro assay. The results indicated significant increases in the inhibition of α‑glucosidase activity in 1,000 µg/ml olive (P<0.01), white willow (P<0.01) and red rooibos hot‑water extracts. Furthermore, ≥50% inhibition of α‑glucosidase activity was determined to be significant in 1,000 µg/ml coltsfoot, green tea and bearberry hot‑water extracts. In addition, the effects of bearberry, green tea and coltsfoot hot‑water extracts on α‑glucosidase activity in vivo were evaluated according to the blood glucose levels (BGLs) in maltose and glucose load model rats. It was indicated that the administration of these three herb extracts significantly reduced the increasing BGLs after maltose loading until 0.5 h compared with the control group. However, only coltsfoot extract significantly reduced the increasing BGLs after glucose loading until 0.5 h compared with the control group. Thus, the present results may facilitate the understanding of a novel functionality in traditional herbs, which could be useful for the prevention of disease onset and progression, such as in hyperglycemia and type 2 diabetes.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32945423</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-3004</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Molecular medicine reports</Title><ISOAbbreviation>Mol Med Rep</ISOAbbreviation></Journal><ArticleTitle>Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity.</ArticleTitle><Pagination><MedlinePgn>3525-3532</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3892/mmr.2020.11397</ELocationID><Abstract><AbstractText>α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the presence of the α‑glucosidase inhibitory activity in herbs, in which various functional effects have been known to occur, the present study investigated the effects of hot‑water extracts of 26 types of herbs on α‑glucosidase activity in an in vitro assay. The results indicated significant increases in the inhibition of α‑glucosidase activity in 1,000 µg/ml olive (P<0.01), white willow (P<0.01) and red rooibos hot‑water extracts. Furthermore, ≥50% inhibition of α‑glucosidase activity was determined to be significant in 1,000 µg/ml coltsfoot, green tea and bearberry hot‑water extracts. In addition, the effects of bearberry, green tea and coltsfoot hot‑water extracts on α‑glucosidase activity in vivo were evaluated according to the blood glucose levels (BGLs) in maltose and glucose load model rats. It was indicated that the administration of these three herb extracts significantly reduced the increasing BGLs after maltose loading until 0.5 h compared with the control group. However, only coltsfoot extract significantly reduced the increasing BGLs after glucose loading until 0.5 h compared with the control group. Thus, the present results may facilitate the understanding of a novel functionality in traditional herbs, which could be useful for the prevention of disease onset and progression, such as in hyperglycemia and type 2 diabetes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kikuchi</LastName><ForeName>Hidetomo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toyoda</LastName><ForeName>Nana</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ezawa</LastName><ForeName>Satoko</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Shiori</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hibino</LastName><ForeName>Yasuhide</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sunaga</LastName><ForeName>Katsuyoshi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>SunagaLaboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>Mol Med Rep</MedlineTA><NlmUniqueID>101475259</NlmUniqueID><ISSNLinking>1791-2997</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>8</Hour><Minute>43</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32945423</ArticleId><ArticleId IdType="doi">10.3892/mmr.2020.11397</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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