The importance of fermentative conditions for the biotechnological production of lignin modifying enzymes from white-rot fungi.
Identifieur interne : 000506 ( Main/Exploration ); précédent : 000505; suivant : 000507The importance of fermentative conditions for the biotechnological production of lignin modifying enzymes from white-rot fungi.
Auteurs : Francesca Martani [Italie] ; Fabrizio Beltrametti [Italie] ; Danilo Porro [Italie] ; Paola Branduardi [Italie] ; Marina Lotti [Italie]Source :
- FEMS microbiology letters [ 1574-6968 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Laccase, Peroxidases.
- enzymologie : Champignons.
- isolement et purification : Lignine.
- métabolisme : Champignons, Lignine.
- pharmacologie : Milieux de culture.
- Biotechnologie, Fermentation, Oxydoréduction.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Laccase, Peroxidases.
- chemical , isolation & purification : Lignin.
- chemical , metabolism : Lignin.
- chemical , pharmacology : Culture Media.
- enzymology : Fungi.
- metabolism : Fungi.
- Biotechnology, Fermentation, Oxidation-Reduction.
Abstract
White-rot fungi are the main natural producers of lignin-modifying enzymes, i.e. laccases and peroxidases, whose secretion and activity allows the depolymerization of lignin and the release of polysaccharides contained in lignocellulose. These enzymes are able to oxidize, in addition to lignin, a wide spectrum of natural and synthetic substrates, making their industrial and biotechnological application appealing. However, the complex regulation of the synthesis of lignin-modifying enzymes, as well as the heterogeneous physiology of fungi in response to nutrients, makes the use of white-rot fungi as production platforms challenging. Finally, yet importantly, analytical methods are not fully standardized, making evaluations and comparisons ambiguous. Consequently, robust and cost-effective fermentative processes for the production of lignin-modifying enzymes by fungi have not yet been fully established, limiting their industrial exploitation. In this review, we describe the importance of both the media composition and the fermentative conditions for leveraging the fungal potential in terms of production titer and enzymatic biodiversity of lignin-modifying enzymes.
DOI: 10.1093/femsle/fnx134
PubMed: 28655193
Affiliations:
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wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Beltrametti, Fabrizio" sort="Beltrametti, Fabrizio" uniqKey="Beltrametti F" first="Fabrizio" last="Beltrametti">Fabrizio Beltrametti</name><affiliation wicri:level="1"><nlm:affiliation>Actygea S.r.l., Insubrias BioPark, 21040 Gerenzano (VA), Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Actygea S.r.l., Insubrias BioPark, 21040 Gerenzano (VA)</wicri:regionArea><wicri:noRegion>21040 Gerenzano (VA)</wicri:noRegion></affiliation></author><author><name sortKey="Porro, Danilo" sort="Porro, Danilo" uniqKey="Porro D" first="Danilo" last="Porro">Danilo Porro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Branduardi, Paola" sort="Branduardi, Paola" uniqKey="Branduardi P" first="Paola" last="Branduardi">Paola Branduardi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lotti, Marina" sort="Lotti, Marina" uniqKey="Lotti M" first="Marina" last="Lotti">Marina Lotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j">FEMS microbiology letters</title><idno type="eISSN">1574-6968</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biotechnology (MeSH)</term><term>Culture Media (pharmacology)</term><term>Fermentation (MeSH)</term><term>Fungi (enzymology)</term><term>Fungi (metabolism)</term><term>Laccase (biosynthesis)</term><term>Lignin (isolation & purification)</term><term>Lignin (metabolism)</term><term>Oxidation-Reduction (MeSH)</term><term>Peroxidases (biosynthesis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biotechnologie (MeSH)</term><term>Champignons (enzymologie)</term><term>Champignons (métabolisme)</term><term>Fermentation (MeSH)</term><term>Laccase (biosynthèse)</term><term>Lignine (isolement et purification)</term><term>Lignine (métabolisme)</term><term>Milieux de culture (pharmacologie)</term><term>Oxydoréduction (MeSH)</term><term>Peroxidases (biosynthèse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Laccase</term><term>Peroxidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Lignin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lignin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Culture Media</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Laccase</term><term>Peroxidases</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Champignons</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Lignine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Champignons</term><term>Lignine</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Milieux de culture</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biotechnology</term><term>Fermentation</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biotechnologie</term><term>Fermentation</term><term>Oxydoréduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">White-rot fungi are the main natural producers of lignin-modifying enzymes, i.e. laccases and peroxidases, whose secretion and activity allows the depolymerization of lignin and the release of polysaccharides contained in lignocellulose. These enzymes are able to oxidize, in addition to lignin, a wide spectrum of natural and synthetic substrates, making their industrial and biotechnological application appealing. However, the complex regulation of the synthesis of lignin-modifying enzymes, as well as the heterogeneous physiology of fungi in response to nutrients, makes the use of white-rot fungi as production platforms challenging. Finally, yet importantly, analytical methods are not fully standardized, making evaluations and comparisons ambiguous. Consequently, robust and cost-effective fermentative processes for the production of lignin-modifying enzymes by fungi have not yet been fully established, limiting their industrial exploitation. In this review, we describe the importance of both the media composition and the fermentative conditions for leveraging the fungal potential in terms of production titer and enzymatic biodiversity of lignin-modifying enzymes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28655193</PMID><DateCompleted><Year>2018</Year><Month>04</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1574-6968</ISSN><JournalIssue CitedMedium="Internet"><Volume>364</Volume><Issue>13</Issue><PubDate><Year>2017</Year><Month>07</Month><Day>06</Day></PubDate></JournalIssue><Title>FEMS microbiology letters</Title><ISOAbbreviation>FEMS Microbiol Lett</ISOAbbreviation></Journal><ArticleTitle>The importance of fermentative conditions for the biotechnological production of lignin modifying enzymes from white-rot fungi.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1093/femsle/fnx134</ELocationID><Abstract><AbstractText>White-rot fungi are the main natural producers of lignin-modifying enzymes, i.e. laccases and peroxidases, whose secretion and activity allows the depolymerization of lignin and the release of polysaccharides contained in lignocellulose. These enzymes are able to oxidize, in addition to lignin, a wide spectrum of natural and synthetic substrates, making their industrial and biotechnological application appealing. However, the complex regulation of the synthesis of lignin-modifying enzymes, as well as the heterogeneous physiology of fungi in response to nutrients, makes the use of white-rot fungi as production platforms challenging. Finally, yet importantly, analytical methods are not fully standardized, making evaluations and comparisons ambiguous. Consequently, robust and cost-effective fermentative processes for the production of lignin-modifying enzymes by fungi have not yet been fully established, limiting their industrial exploitation. In this review, we describe the importance of both the media composition and the fermentative conditions for leveraging the fungal potential in terms of production titer and enzymatic biodiversity of lignin-modifying enzymes.</AbstractText><CopyrightInformation>© FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martani</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beltrametti</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Actygea S.r.l., Insubrias BioPark, 21040 Gerenzano (VA), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porro</LastName><ForeName>Danilo</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Branduardi</LastName><ForeName>Paola</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lotti</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>FEMS Microbiol 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Media</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005285" MajorTopicYN="Y">Fermentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042845" MajorTopicYN="N">Laccase</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008031" MajorTopicYN="N">Lignin</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010544" MajorTopicYN="N">Peroxidases</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">cell factory</Keyword><Keyword MajorTopicYN="Y">lignin-modifying enzymes (LMEs)</Keyword><Keyword MajorTopicYN="Y">white-rot fungi (WRF)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28655193</ArticleId><ArticleId IdType="pii">3888816</ArticleId><ArticleId IdType="doi">10.1093/femsle/fnx134</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Martani, Francesca" sort="Martani, Francesca" uniqKey="Martani F" first="Francesca" last="Martani">Francesca Martani</name></region><name sortKey="Beltrametti, Fabrizio" sort="Beltrametti, Fabrizio" uniqKey="Beltrametti F" first="Fabrizio" last="Beltrametti">Fabrizio Beltrametti</name><name sortKey="Branduardi, Paola" sort="Branduardi, Paola" uniqKey="Branduardi P" first="Paola" last="Branduardi">Paola Branduardi</name><name sortKey="Lotti, Marina" sort="Lotti, Marina" uniqKey="Lotti M" first="Marina" last="Lotti">Marina Lotti</name><name sortKey="Porro, Danilo" sort="Porro, Danilo" uniqKey="Porro D" first="Danilo" last="Porro">Danilo Porro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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