Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.
Identifieur interne : 000476 ( Main/Curation ); précédent : 000475; suivant : 000477Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.
Auteurs : Elide A. Pastorello [Italie] ; Laura Farioli ; Valerio Pravettoni ; Claudio Ortolani ; Donatella Fortunato ; Maria Gabriella Giuffrida ; Lorenza Perono Garoffo ; Ambra Marianna Calamari ; Oreste Brenna ; Amedeo ContiSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allergènes (composition chimique), Allergènes (isolement et purification), Antigènes végétaux (MeSH), Chitinase (immunologie), Données de séquences moléculaires (MeSH), Femelle (MeSH), Humains (MeSH), Hypersensibilité alimentaire (immunologie), Hypersensibilité alimentaire (étiologie), Immunoglobuline E (sang), Immunotransfert (MeSH), Mâle (MeSH), Protéines de transport (immunologie), Protéines végétales (immunologie), Réactions croisées (MeSH), Spectrométrie de masse ESI (MeSH), Séquence d'acides aminés (MeSH), Vin (analyse), Vin (effets indésirables), Vitis (composition chimique), Vitis (effets indésirables), Vitis (immunologie), Édulcorants (MeSH).
- MESH :
- analyse : Vin.
- composition chimique : Allergènes, Vitis.
- effets indésirables : Vin, Vitis.
- immunologie : Chitinase, Hypersensibilité alimentaire, Protéines de transport, Protéines végétales, Vitis.
- isolement et purification : Allergènes.
- sang : Immunoglobuline E.
- étiologie : Hypersensibilité alimentaire.
- Adulte, Adulte d'âge moyen, Antigènes végétaux, Données de séquences moléculaires, Femelle, Humains, Immunotransfert, Mâle, Réactions croisées, Spectrométrie de masse ESI, Séquence d'acides aminés, Édulcorants.
English descriptors
- KwdEn :
- Adult (MeSH), Allergens (chemistry), Allergens (isolation & purification), Amino Acid Sequence (MeSH), Antigens, Plant (MeSH), Carrier Proteins (immunology), Chitinases (immunology), Cross Reactions (MeSH), Female (MeSH), Food Hypersensitivity (etiology), Food Hypersensitivity (immunology), Humans (MeSH), Immunoblotting (MeSH), Immunoglobulin E (blood), Male (MeSH), Middle Aged (MeSH), Molecular Sequence Data (MeSH), Plant Proteins (immunology), Spectrometry, Mass, Electrospray Ionization (MeSH), Sweetening Agents (MeSH), Vitis (adverse effects), Vitis (chemistry), Vitis (immunology), Wine (adverse effects), Wine (analysis).
- MESH :
- chemical , blood : Immunoglobulin E.
- chemical , chemistry : Allergens.
- chemical , immunology : Carrier Proteins, Chitinases, Plant Proteins.
- chemical , isolation & purification : Allergens.
- adverse effects : Vitis, Wine.
- analysis : Wine.
- chemistry : Vitis.
- etiology : Food Hypersensitivity.
- immunology : Food Hypersensitivity, Vitis.
- Adult, Amino Acid Sequence, Antigens, Plant, Cross Reactions, Female, Humans, Immunoblotting, Male, Middle Aged, Molecular Sequence Data, Spectrometry, Mass, Electrospray Ionization, Sweetening Agents.
Abstract
BACKGROUND
Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.
OBJECTIVE
We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.
METHODS
We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.
RESULTS
Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.
CONCLUSIONS
Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.
DOI: 10.1067/mai.2003.35
PubMed: 12589356
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pubmed:12589356Le document en format XML
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<term>Allergens (isolation & purification)</term>
<term>Amino Acid Sequence (MeSH)</term>
<term>Antigens, Plant (MeSH)</term>
<term>Carrier Proteins (immunology)</term>
<term>Chitinases (immunology)</term>
<term>Cross Reactions (MeSH)</term>
<term>Female (MeSH)</term>
<term>Food Hypersensitivity (etiology)</term>
<term>Food Hypersensitivity (immunology)</term>
<term>Humans (MeSH)</term>
<term>Immunoblotting (MeSH)</term>
<term>Immunoglobulin E (blood)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Plant Proteins (immunology)</term>
<term>Spectrometry, Mass, Electrospray Ionization (MeSH)</term>
<term>Sweetening Agents (MeSH)</term>
<term>Vitis (adverse effects)</term>
<term>Vitis (chemistry)</term>
<term>Vitis (immunology)</term>
<term>Wine (adverse effects)</term>
<term>Wine (analysis)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
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<term>Allergènes (isolement et purification)</term>
<term>Antigènes végétaux (MeSH)</term>
<term>Chitinase (immunologie)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hypersensibilité alimentaire (immunologie)</term>
<term>Hypersensibilité alimentaire (étiologie)</term>
<term>Immunoglobuline E (sang)</term>
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<term>Mâle (MeSH)</term>
<term>Protéines de transport (immunologie)</term>
<term>Protéines végétales (immunologie)</term>
<term>Réactions croisées (MeSH)</term>
<term>Spectrométrie de masse ESI (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Vin (analyse)</term>
<term>Vin (effets indésirables)</term>
<term>Vitis (composition chimique)</term>
<term>Vitis (effets indésirables)</term>
<term>Vitis (immunologie)</term>
<term>Édulcorants (MeSH)</term>
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<term>Wine</term>
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<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Vin</term>
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<keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Wine</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vin</term>
<term>Vitis</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Food Hypersensitivity</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chitinase</term>
<term>Hypersensibilité alimentaire</term>
<term>Protéines de transport</term>
<term>Protéines végétales</term>
<term>Vitis</term>
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<term>Amino Acid Sequence</term>
<term>Antigens, Plant</term>
<term>Cross Reactions</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Spectrometry, Mass, Electrospray Ionization</term>
<term>Sweetening Agents</term>
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<term>Adulte d'âge moyen</term>
<term>Antigènes végétaux</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
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<term>Immunotransfert</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12589356</PMID>
<DateCompleted><Year>2003</Year>
<Month>03</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-6749</ISSN>
<JournalIssue CitedMedium="Print"><Volume>111</Volume>
<Issue>2</Issue>
<PubDate><Year>2003</Year>
<Month>Feb</Month>
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<Title>The Journal of allergy and clinical immunology</Title>
<ISOAbbreviation>J Allergy Clin Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein, and a thaumatin.</ArticleTitle>
<Pagination><MedlinePgn>350-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We collected documented histories of allergic reactions to grape and wine. Grape allergens were identified by means of SDS-PAGE and immunoblotting and purified by means of HPLC. Using amino acid sequencing and mass spectrometry, we identified the family of proteins to which the allergens belong. Cross-reactivity with peach and cherry was evaluated by means of cross-wise inhibition experiments.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Eleven patients with reactions to grape and 3 with anaphylactic reactions to wine were recruited. The major allergens were an endochitinase 4A and a lipid-transfer protein (LTP) that was homologous to and cross-reactive with peach LTP. A 24-kd protein homologous to the cherry thaumatin-like allergen was a minor allergen. Endochitinase 4A is very likely the allergen in vino novello and in vino Fragolino.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Grape and wine might cause severe allergic reactions in sensitive patients. The major allergens of grape are endochitinase 4A, which is also the allergen of wine, and an LTP cross-reacting with the peach major allergen.</AbstractText>
</Abstract>
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<ForeName>Elide A</ForeName>
<Initials>EA</Initials>
<AffiliationInfo><Affiliation>Allergy Center, First Division of General Medicine, Ospedale Maggiore IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy.</Affiliation>
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<ForeName>Claudio</ForeName>
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<ForeName>Donatella</ForeName>
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<Author ValidYN="Y"><LastName>Giuffrida</LastName>
<ForeName>Maria Gabriella</ForeName>
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<Author ValidYN="Y"><LastName>Perono Garoffo</LastName>
<ForeName>Lorenza</ForeName>
<Initials>L</Initials>
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<ForeName>Ambra Marianna</ForeName>
<Initials>AM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Brenna</LastName>
<ForeName>Oreste</ForeName>
<Initials>O</Initials>
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<Author ValidYN="Y"><LastName>Conti</LastName>
<ForeName>Amedeo</ForeName>
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