Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
Identifieur interne : 000384 ( Main/Curation ); précédent : 000383; suivant : 000385Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
Auteurs : Michiko Yamagata [États-Unis] ; Susan L. Rook ; Yukio Sassa ; Ronald C. Ma ; Pedro Geraldes ; Lucy Goddard ; Allen Clermont ; Benbo Gao ; Haytham Salti ; Robert Gundel ; Mark White ; Edward P. Feener ; Lloyd Paul Aiello ; George L. KingSource :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology [ 1530-6860 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Apoptose (effets des médicaments et des substances chimiques), Bovins (MeSH), Cellules cultivées (MeSH), Cellules endothéliales (cytologie), Cellules endothéliales (effets des médicaments et des substances chimiques), Cellules endothéliales (métabolisme), Corps vitré (composition chimique), Facteur de croissance endothéliale vasculaire de type A (pharmacologie), Humains (MeSH), Inhibiteurs de l'angiogenèse (pharmacologie), Néovascularisation pathologique (traitement médicamenteux), Peptides antimicrobiens cationiques (analyse), Peptides antimicrobiens cationiques (pharmacologie), Perméabilité capillaire (effets des médicaments et des substances chimiques), Plasma sanguin (composition chimique), Protéines du sang (analyse), Protéines du sang (pharmacologie), Protéines membranaires (analyse), Protéines membranaires (pharmacologie), Protéines recombinantes (pharmacologie), Péricytes (cytologie), Péricytes (effets des médicaments et des substances chimiques), Péricytes (métabolisme), Rétine (cytologie), Rétine (effets des médicaments et des substances chimiques), Rétine (métabolisme), Transduction du signal (MeSH), Vaisseaux rétiniens (croissance et développement), Vaisseaux rétiniens (effets des médicaments et des substances chimiques), Épithélium pigmentaire de l'oeil (cytologie), Épithélium pigmentaire de l'oeil (effets des médicaments et des substances chimiques), Épithélium pigmentaire de l'oeil (métabolisme).
- MESH :
- analyse : Peptides antimicrobiens cationiques, Protéines du sang, Protéines membranaires.
- composition chimique : Corps vitré, Plasma sanguin.
- croissance et développement : Vaisseaux rétiniens.
- cytologie : Cellules endothéliales, Péricytes, Rétine, Épithélium pigmentaire de l'oeil.
- effets des médicaments et des substances chimiques : Apoptose, Cellules endothéliales, Perméabilité capillaire, Péricytes, Rétine, Vaisseaux rétiniens, Épithélium pigmentaire de l'oeil.
- métabolisme : Cellules endothéliales, Péricytes, Rétine, Épithélium pigmentaire de l'oeil.
- pharmacologie : Facteur de croissance endothéliale vasculaire de type A, Inhibiteurs de l'angiogenèse, Peptides antimicrobiens cationiques, Protéines du sang, Protéines membranaires, Protéines recombinantes.
- traitement médicamenteux : Néovascularisation pathologique.
- Animaux, Bovins, Cellules cultivées, Humains, Transduction du signal.
English descriptors
- KwdEn :
- Angiogenesis Inhibitors (pharmacology), Animals (MeSH), Antimicrobial Cationic Peptides (analysis), Antimicrobial Cationic Peptides (pharmacology), Apoptosis (drug effects), Blood Proteins (analysis), Blood Proteins (pharmacology), Capillary Permeability (drug effects), Cattle (MeSH), Cells, Cultured (MeSH), Endothelial Cells (cytology), Endothelial Cells (drug effects), Endothelial Cells (metabolism), Humans (MeSH), Membrane Proteins (analysis), Membrane Proteins (pharmacology), Neovascularization, Pathologic (drug therapy), Pericytes (cytology), Pericytes (drug effects), Pericytes (metabolism), Pigment Epithelium of Eye (cytology), Pigment Epithelium of Eye (drug effects), Pigment Epithelium of Eye (metabolism), Plasma (chemistry), Recombinant Proteins (pharmacology), Retina (cytology), Retina (drug effects), Retina (metabolism), Retinal Vessels (drug effects), Retinal Vessels (growth & development), Signal Transduction (MeSH), Vascular Endothelial Growth Factor A (pharmacology), Vitreous Body (chemistry).
- MESH :
- chemical , analysis : Antimicrobial Cationic Peptides, Blood Proteins, Membrane Proteins.
- chemical , pharmacology : Angiogenesis Inhibitors, Antimicrobial Cationic Peptides, Blood Proteins, Membrane Proteins, Recombinant Proteins, Vascular Endothelial Growth Factor A.
- chemistry : Plasma, Vitreous Body.
- cytology : Endothelial Cells, Pericytes, Pigment Epithelium of Eye, Retina.
- drug effects : Apoptosis, Capillary Permeability, Endothelial Cells, Pericytes, Pigment Epithelium of Eye, Retina, Retinal Vessels.
- drug therapy : Neovascularization, Pathologic.
- growth & development : Retinal Vessels.
- metabolism : Endothelial Cells, Pericytes, Pigment Epithelium of Eye, Retina.
- Animals, Cattle, Cells, Cultured, Humans, Signal Transduction.
Abstract
Bactericidal/permeability-increasing protein (BPI) was originally identified as a lipopolysaccharide (LPS) binding protein with gram-negative bactericidal activity in the leukocytes. In this study, we characterized the previously unknown effects of BPI in the eye and the molecular mechanisms involved in its action. BPI mRNA was detected in bovine retina; retinal pigment epithelium; and primary cultures of bovine retinal pigment epithelial cells (RPE), pericytes (RPC), and endothelial cells (REC); while BPI protein was measured in human vitreous and plasma. BPI, but not control protein thaumatin, activated extracellular regulated kinase (ERK) and AKT, and increased DNA synthesis in RPE and RPC but not in REC. A human recombinant 21 kDa modified amino-terminal fragment of BPI (rBPI21) reduced H2O2-induced apoptosis in RPE and inhibited vascular endothelial growth factor (VEGF)-stimulated ERK phosphorylation in REC when preincubated with VEGF. Intraperitoneal (i.p.)-injected rBPI21 reduced ischemia-induced retinal neovascularization and diabetes-induced retinal permeability. Since BPI has unusual dual properties of promoting RPC and RPE growth while suppressing VEGF-induced REC growth and vascular permeability, the mechanistic understanding of BPI's action may provide novel therapeutic opportunities for diabetic retinopathy and age-related macular degeneration.
DOI: 10.1096/05-5662com
PubMed: 17012258
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000384
Links to Exploration step
pubmed:17012258Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.</title><author><name sortKey="Yamagata, Michiko" sort="Yamagata, Michiko" uniqKey="Yamagata M" first="Michiko" last="Yamagata">Michiko Yamagata</name><affiliation wicri:level="1"><nlm:affiliation>Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215</wicri:regionArea></affiliation></author><author><name sortKey="Rook, Susan L" sort="Rook, Susan L" uniqKey="Rook S" first="Susan L" last="Rook">Susan L. Rook</name></author><author><name sortKey="Sassa, Yukio" sort="Sassa, Yukio" uniqKey="Sassa Y" first="Yukio" last="Sassa">Yukio Sassa</name></author><author><name sortKey="Ma, Ronald C" sort="Ma, Ronald C" uniqKey="Ma R" first="Ronald C" last="Ma">Ronald C. Ma</name></author><author><name sortKey="Geraldes, Pedro" sort="Geraldes, Pedro" uniqKey="Geraldes P" first="Pedro" last="Geraldes">Pedro Geraldes</name></author><author><name sortKey="Goddard, Lucy" sort="Goddard, Lucy" uniqKey="Goddard L" first="Lucy" last="Goddard">Lucy Goddard</name></author><author><name sortKey="Clermont, Allen" sort="Clermont, Allen" uniqKey="Clermont A" first="Allen" last="Clermont">Allen Clermont</name></author><author><name sortKey="Gao, Benbo" sort="Gao, Benbo" uniqKey="Gao B" first="Benbo" last="Gao">Benbo Gao</name></author><author><name sortKey="Salti, Haytham" sort="Salti, Haytham" uniqKey="Salti H" first="Haytham" last="Salti">Haytham Salti</name></author><author><name sortKey="Gundel, Robert" sort="Gundel, Robert" uniqKey="Gundel R" first="Robert" last="Gundel">Robert Gundel</name></author><author><name sortKey="White, Mark" sort="White, Mark" uniqKey="White M" first="Mark" last="White">Mark White</name></author><author><name sortKey="Feener, Edward P" sort="Feener, Edward P" uniqKey="Feener E" first="Edward P" last="Feener">Edward P. Feener</name></author><author><name sortKey="Aiello, Lloyd Paul" sort="Aiello, Lloyd Paul" uniqKey="Aiello L" first="Lloyd Paul" last="Aiello">Lloyd Paul Aiello</name></author><author><name sortKey="King, George L" sort="King, George L" uniqKey="King G" first="George L" last="King">George L. King</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:17012258</idno><idno type="pmid">17012258</idno><idno type="doi">10.1096/05-5662com</idno><idno type="wicri:Area/Main/Corpus">000384</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000384</idno><idno type="wicri:Area/Main/Curation">000384</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000384</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.</title><author><name sortKey="Yamagata, Michiko" sort="Yamagata, Michiko" uniqKey="Yamagata M" first="Michiko" last="Yamagata">Michiko Yamagata</name><affiliation wicri:level="1"><nlm:affiliation>Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215</wicri:regionArea></affiliation></author><author><name sortKey="Rook, Susan L" sort="Rook, Susan L" uniqKey="Rook S" first="Susan L" last="Rook">Susan L. Rook</name></author><author><name sortKey="Sassa, Yukio" sort="Sassa, Yukio" uniqKey="Sassa Y" first="Yukio" last="Sassa">Yukio Sassa</name></author><author><name sortKey="Ma, Ronald C" sort="Ma, Ronald C" uniqKey="Ma R" first="Ronald C" last="Ma">Ronald C. Ma</name></author><author><name sortKey="Geraldes, Pedro" sort="Geraldes, Pedro" uniqKey="Geraldes P" first="Pedro" last="Geraldes">Pedro Geraldes</name></author><author><name sortKey="Goddard, Lucy" sort="Goddard, Lucy" uniqKey="Goddard L" first="Lucy" last="Goddard">Lucy Goddard</name></author><author><name sortKey="Clermont, Allen" sort="Clermont, Allen" uniqKey="Clermont A" first="Allen" last="Clermont">Allen Clermont</name></author><author><name sortKey="Gao, Benbo" sort="Gao, Benbo" uniqKey="Gao B" first="Benbo" last="Gao">Benbo Gao</name></author><author><name sortKey="Salti, Haytham" sort="Salti, Haytham" uniqKey="Salti H" first="Haytham" last="Salti">Haytham Salti</name></author><author><name sortKey="Gundel, Robert" sort="Gundel, Robert" uniqKey="Gundel R" first="Robert" last="Gundel">Robert Gundel</name></author><author><name sortKey="White, Mark" sort="White, Mark" uniqKey="White M" first="Mark" last="White">Mark White</name></author><author><name sortKey="Feener, Edward P" sort="Feener, Edward P" uniqKey="Feener E" first="Edward P" last="Feener">Edward P. Feener</name></author><author><name sortKey="Aiello, Lloyd Paul" sort="Aiello, Lloyd Paul" uniqKey="Aiello L" first="Lloyd Paul" last="Aiello">Lloyd Paul Aiello</name></author><author><name sortKey="King, George L" sort="King, George L" uniqKey="King G" first="George L" last="King">George L. King</name></author></analytic><series><title level="j">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</title><idno type="eISSN">1530-6860</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiogenesis Inhibitors (pharmacology)</term><term>Animals (MeSH)</term><term>Antimicrobial Cationic Peptides (analysis)</term><term>Antimicrobial Cationic Peptides (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Blood Proteins (analysis)</term><term>Blood Proteins (pharmacology)</term><term>Capillary Permeability (drug effects)</term><term>Cattle (MeSH)</term><term>Cells, Cultured (MeSH)</term><term>Endothelial Cells (cytology)</term><term>Endothelial Cells (drug effects)</term><term>Endothelial Cells (metabolism)</term><term>Humans (MeSH)</term><term>Membrane Proteins (analysis)</term><term>Membrane Proteins (pharmacology)</term><term>Neovascularization, Pathologic (drug therapy)</term><term>Pericytes (cytology)</term><term>Pericytes (drug effects)</term><term>Pericytes (metabolism)</term><term>Pigment Epithelium of Eye (cytology)</term><term>Pigment Epithelium of Eye (drug effects)</term><term>Pigment Epithelium of Eye (metabolism)</term><term>Plasma (chemistry)</term><term>Recombinant Proteins (pharmacology)</term><term>Retina (cytology)</term><term>Retina (drug effects)</term><term>Retina (metabolism)</term><term>Retinal Vessels (drug effects)</term><term>Retinal Vessels (growth & development)</term><term>Signal Transduction (MeSH)</term><term>Vascular Endothelial Growth Factor A (pharmacology)</term><term>Vitreous Body (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Bovins (MeSH)</term><term>Cellules cultivées (MeSH)</term><term>Cellules endothéliales (cytologie)</term><term>Cellules endothéliales (effets des médicaments et des substances chimiques)</term><term>Cellules endothéliales (métabolisme)</term><term>Corps vitré (composition chimique)</term><term>Facteur de croissance endothéliale vasculaire de type A (pharmacologie)</term><term>Humains (MeSH)</term><term>Inhibiteurs de l'angiogenèse (pharmacologie)</term><term>Néovascularisation pathologique (traitement médicamenteux)</term><term>Peptides antimicrobiens cationiques (analyse)</term><term>Peptides antimicrobiens cationiques (pharmacologie)</term><term>Perméabilité capillaire (effets des médicaments et des substances chimiques)</term><term>Plasma sanguin (composition chimique)</term><term>Protéines du sang (analyse)</term><term>Protéines du sang (pharmacologie)</term><term>Protéines membranaires (analyse)</term><term>Protéines membranaires (pharmacologie)</term><term>Protéines recombinantes (pharmacologie)</term><term>Péricytes (cytologie)</term><term>Péricytes (effets des médicaments et des substances chimiques)</term><term>Péricytes (métabolisme)</term><term>Rétine (cytologie)</term><term>Rétine (effets des médicaments et des substances chimiques)</term><term>Rétine (métabolisme)</term><term>Transduction du signal (MeSH)</term><term>Vaisseaux rétiniens (croissance et développement)</term><term>Vaisseaux rétiniens (effets des médicaments et des substances chimiques)</term><term>Épithélium pigmentaire de l'oeil (cytologie)</term><term>Épithélium pigmentaire de l'oeil (effets des médicaments et des substances chimiques)</term><term>Épithélium pigmentaire de l'oeil (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antimicrobial Cationic Peptides</term><term>Blood Proteins</term><term>Membrane Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Angiogenesis Inhibitors</term><term>Antimicrobial Cationic Peptides</term><term>Blood Proteins</term><term>Membrane Proteins</term><term>Recombinant Proteins</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Peptides antimicrobiens cationiques</term><term>Protéines du sang</term><term>Protéines membranaires</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term><term>Vitreous Body</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Corps vitré</term><term>Plasma sanguin</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Vaisseaux rétiniens</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Péricytes</term><term>Rétine</term><term>Épithélium pigmentaire de l'oeil</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term><term>Pericytes</term><term>Pigment Epithelium of Eye</term><term>Retina</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Capillary Permeability</term><term>Endothelial Cells</term><term>Pericytes</term><term>Pigment Epithelium of Eye</term><term>Retina</term><term>Retinal Vessels</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neovascularization, Pathologic</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term><term>Cellules endothéliales</term><term>Perméabilité capillaire</term><term>Péricytes</term><term>Rétine</term><term>Vaisseaux rétiniens</term><term>Épithélium pigmentaire de l'oeil</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Retinal Vessels</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term><term>Pericytes</term><term>Pigment Epithelium of Eye</term><term>Retina</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term><term>Péricytes</term><term>Rétine</term><term>Épithélium pigmentaire de l'oeil</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Inhibiteurs de l'angiogenèse</term><term>Peptides antimicrobiens cationiques</term><term>Protéines du sang</term><term>Protéines membranaires</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Néovascularisation pathologique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cattle</term><term>Cells, Cultured</term><term>Humans</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Cellules cultivées</term><term>Humains</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bactericidal/permeability-increasing protein (BPI) was originally identified as a lipopolysaccharide (LPS) binding protein with gram-negative bactericidal activity in the leukocytes. In this study, we characterized the previously unknown effects of BPI in the eye and the molecular mechanisms involved in its action. BPI mRNA was detected in bovine retina; retinal pigment epithelium; and primary cultures of bovine retinal pigment epithelial cells (RPE), pericytes (RPC), and endothelial cells (REC); while BPI protein was measured in human vitreous and plasma. BPI, but not control protein thaumatin, activated extracellular regulated kinase (ERK) and AKT, and increased DNA synthesis in RPE and RPC but not in REC. A human recombinant 21 kDa modified amino-terminal fragment of BPI (rBPI21) reduced H2O2-induced apoptosis in RPE and inhibited vascular endothelial growth factor (VEGF)-stimulated ERK phosphorylation in REC when preincubated with VEGF. Intraperitoneal (i.p.)-injected rBPI21 reduced ischemia-induced retinal neovascularization and diabetes-induced retinal permeability. Since BPI has unusual dual properties of promoting RPC and RPE growth while suppressing VEGF-induced REC growth and vascular permeability, the mechanistic understanding of BPI's action may provide novel therapeutic opportunities for diabetic retinopathy and age-related macular degeneration.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17012258</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>04</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-6860</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>12</Issue><PubDate><Year>2006</Year><Month>Oct</Month></PubDate></JournalIssue><Title>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</Title><ISOAbbreviation>FASEB J</ISOAbbreviation></Journal><ArticleTitle>Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.</ArticleTitle><Pagination><MedlinePgn>2058-67</MedlinePgn></Pagination><Abstract><AbstractText>Bactericidal/permeability-increasing protein (BPI) was originally identified as a lipopolysaccharide (LPS) binding protein with gram-negative bactericidal activity in the leukocytes. In this study, we characterized the previously unknown effects of BPI in the eye and the molecular mechanisms involved in its action. BPI mRNA was detected in bovine retina; retinal pigment epithelium; and primary cultures of bovine retinal pigment epithelial cells (RPE), pericytes (RPC), and endothelial cells (REC); while BPI protein was measured in human vitreous and plasma. BPI, but not control protein thaumatin, activated extracellular regulated kinase (ERK) and AKT, and increased DNA synthesis in RPE and RPC but not in REC. A human recombinant 21 kDa modified amino-terminal fragment of BPI (rBPI21) reduced H2O2-induced apoptosis in RPE and inhibited vascular endothelial growth factor (VEGF)-stimulated ERK phosphorylation in REC when preincubated with VEGF. Intraperitoneal (i.p.)-injected rBPI21 reduced ischemia-induced retinal neovascularization and diabetes-induced retinal permeability. Since BPI has unusual dual properties of promoting RPC and RPE growth while suppressing VEGF-induced REC growth and vascular permeability, the mechanistic understanding of BPI's action may provide novel therapeutic opportunities for diabetic retinopathy and age-related macular degeneration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yamagata</LastName><ForeName>Michiko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rook</LastName><ForeName>Susan L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Sassa</LastName><ForeName>Yukio</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Ronald C</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Geraldes</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Goddard</LastName><ForeName>Lucy</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Clermont</LastName><ForeName>Allen</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Benbo</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Salti</LastName><ForeName>Haytham</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Gundel</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Feener</LastName><ForeName>Edward P</ForeName><Initials>EP</Initials></Author><Author ValidYN="Y"><LastName>Aiello</LastName><ForeName>Lloyd Paul</ForeName><Initials>LP</Initials></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>George L</ForeName><Initials>GL</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 DK36836</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>FASEB J</MedlineTA><NlmUniqueID>8804484</NlmUniqueID><ISSNLinking>0892-6638</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020533">Angiogenesis Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D023181">Antimicrobial Cationic Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001798">Blood Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C467484">VEGFA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C021623">bactericidal permeability increasing protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D020533" MajorTopicYN="N">Angiogenesis Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023181" MajorTopicYN="N">Antimicrobial Cationic Peptides</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001798" MajorTopicYN="N">Blood Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002199" MajorTopicYN="N">Capillary Permeability</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009389" MajorTopicYN="N">Neovascularization, Pathologic</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020286" MajorTopicYN="N">Pericytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010857" MajorTopicYN="N">Pigment Epithelium of Eye</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="N">Plasma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012160" MajorTopicYN="N">Retina</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012171" MajorTopicYN="N">Retinal Vessels</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014822" MajorTopicYN="N">Vitreous Body</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>10</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>10</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>10</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17012258</ArticleId><ArticleId IdType="pii">20/12/2058</ArticleId><ArticleId IdType="doi">10.1096/05-5662com</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/ThaumatinV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000384 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000384 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= ThaumatinV1
|flux= Main
|étape= Curation
|type= RBID
|clé= pubmed:17012258
|texte= Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:17012258" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ThaumatinV1
| This area was generated with Dilib version V0.6.37. |  |