Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome.
Identifieur interne : 000371 ( Main/Curation ); précédent : 000370; suivant : 000372Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome.
Auteurs : Emilia Vassilopoulou [Grèce] ; Laurian Zuidmeer ; Jaap Akkerdaas ; Ioannis Tassios ; Neil R. Rigby ; E N Clare Mills ; Ronald Van Ree ; Photini Saxoni-Papageorgiou ; Nikolaos G. PapadopoulosSource :
- International archives of allergy and immunology [ 1018-2438 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Antigènes végétaux (immunologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Humains (MeSH), Hypersensibilité alimentaire (immunologie), Hypersensibilité immédiate (immunologie), Immunoglobuline E (sang), Mâle (MeSH), Protéines de transport (immunologie), Protéomique (MeSH), Technique de Western (MeSH), Test RAST (MeSH), Vitis (composition chimique), Vitis (immunologie), Électrophorèse sur gel de polyacrylamide (MeSH).
- MESH :
- composition chimique : Vitis.
- immunologie : Antigènes végétaux, Hypersensibilité alimentaire, Hypersensibilité immédiate, Protéines de transport, Vitis.
- sang : Immunoglobuline E.
- Adolescent, Adulte, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Protéomique, Technique de Western, Test RAST, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Antigens, Plant (immunology), Blotting, Western (MeSH), Carrier Proteins (immunology), Child (MeSH), Child, Preschool (MeSH), Electrophoresis, Polyacrylamide Gel (MeSH), Female (MeSH), Food Hypersensitivity (immunology), Humans (MeSH), Hypersensitivity, Immediate (immunology), Immunoglobulin E (blood), Male (MeSH), Proteomics (MeSH), Radioallergosorbent Test (MeSH), Vitis (chemistry), Vitis (immunology).
- MESH :
- chemical , blood : Immunoglobulin E.
- chemical , immunology : Antigens, Plant, Carrier Proteins.
- chemistry : Vitis.
- immunology : Food Hypersensitivity, Hypersensitivity, Immediate, Vitis.
- Adolescent, Adult, Blotting, Western, Child, Child, Preschool, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Proteomics, Radioallergosorbent Test.
Abstract
BACKGROUND
Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected.
OBJECTIVES
The aim of this study was to identify and characterise the allergens involved in severe allergic reactions to grapes and describe the population in which they occur.
METHODS
Patients with reported severe allergic reactions to grapes (n = 37) are described. Grape allergens were purified/fractionated by a combination of chromatographic techniques, identified by proteomic analysis and biochemically characterised. Immunoreactivity was assessed by blot (inhibitions) and RAST (inhibitions), and skin prick tests were performed with the isolated allergens.
RESULTS
All subjects were polyallergic, sensitised and reactive to several additional foods and pollen. All patients were sensitised to grape LTP. A 28-kDa expansin, a 37.5-kDa polygalacturonase-inhibiting protein, a 39-kDa beta-1,3-glucanase and a 60-kDa protein were identified as minor grape allergens. Endochitinase and TLP did not play a role. Inhibition experiments revealed the possible cross-reactive role of LTP for clinical sensitivities to other LTP-containing plant foods, but also the involvement of cross-reactive carbohydrate determinants of minor allergens in IgE cross-reactivity.
CONCLUSIONS
LTP is the major grape allergen, while additional minor allergens may contribute to clinical reactivity. Severe grape allergy presents in atopic patients who frequently react to other LTP-containing, plant-derived foods. The 'LTP syndrome' is the appropriate term to describe this condition.
DOI: 10.1159/000098657
PubMed: 17228170
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pubmed:17228170Le document en format XML
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<author><name sortKey="Papadopoulos, Nikolaos G" sort="Papadopoulos, Nikolaos G" uniqKey="Papadopoulos N" first="Nikolaos G" last="Papadopoulos">Nikolaos G. Papadopoulos</name>
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<series><title level="j">International archives of allergy and immunology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Antigens, Plant (immunology)</term>
<term>Blotting, Western (MeSH)</term>
<term>Carrier Proteins (immunology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Electrophoresis, Polyacrylamide Gel (MeSH)</term>
<term>Female (MeSH)</term>
<term>Food Hypersensitivity (immunology)</term>
<term>Humans (MeSH)</term>
<term>Hypersensitivity, Immediate (immunology)</term>
<term>Immunoglobulin E (blood)</term>
<term>Male (MeSH)</term>
<term>Proteomics (MeSH)</term>
<term>Radioallergosorbent Test (MeSH)</term>
<term>Vitis (chemistry)</term>
<term>Vitis (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Antigènes végétaux (immunologie)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hypersensibilité alimentaire (immunologie)</term>
<term>Hypersensibilité immédiate (immunologie)</term>
<term>Immunoglobuline E (sang)</term>
<term>Mâle (MeSH)</term>
<term>Protéines de transport (immunologie)</term>
<term>Protéomique (MeSH)</term>
<term>Technique de Western (MeSH)</term>
<term>Test RAST (MeSH)</term>
<term>Vitis (composition chimique)</term>
<term>Vitis (immunologie)</term>
<term>Électrophorèse sur gel de polyacrylamide (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Plant</term>
<term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Vitis</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Vitis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes végétaux</term>
<term>Hypersensibilité alimentaire</term>
<term>Hypersensibilité immédiate</term>
<term>Protéines de transport</term>
<term>Vitis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Food Hypersensitivity</term>
<term>Hypersensitivity, Immediate</term>
<term>Vitis</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Blotting, Western</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Proteomics</term>
<term>Radioallergosorbent Test</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Protéomique</term>
<term>Technique de Western</term>
<term>Test RAST</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>The aim of this study was to identify and characterise the allergens involved in severe allergic reactions to grapes and describe the population in which they occur.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Patients with reported severe allergic reactions to grapes (n = 37) are described. Grape allergens were purified/fractionated by a combination of chromatographic techniques, identified by proteomic analysis and biochemically characterised. Immunoreactivity was assessed by blot (inhibitions) and RAST (inhibitions), and skin prick tests were performed with the isolated allergens.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>All subjects were polyallergic, sensitised and reactive to several additional foods and pollen. All patients were sensitised to grape LTP. A 28-kDa expansin, a 37.5-kDa polygalacturonase-inhibiting protein, a 39-kDa beta-1,3-glucanase and a 60-kDa protein were identified as minor grape allergens. Endochitinase and TLP did not play a role. Inhibition experiments revealed the possible cross-reactive role of LTP for clinical sensitivities to other LTP-containing plant foods, but also the involvement of cross-reactive carbohydrate determinants of minor allergens in IgE cross-reactivity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>LTP is the major grape allergen, while additional minor allergens may contribute to clinical reactivity. Severe grape allergy presents in atopic patients who frequently react to other LTP-containing, plant-derived foods. The 'LTP syndrome' is the appropriate term to describe this condition.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2007</Year>
<Month>06</Month>
<Day>26</Day>
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<Title>International archives of allergy and immunology</Title>
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<ArticleTitle>Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Grape allergy is considered rare; grape lipid transfer protein (LTP; Vit v 1), an endochitinase and a thaumatin-like protein (TLP) have been reported as grape allergens. A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this study was to identify and characterise the allergens involved in severe allergic reactions to grapes and describe the population in which they occur.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Patients with reported severe allergic reactions to grapes (n = 37) are described. Grape allergens were purified/fractionated by a combination of chromatographic techniques, identified by proteomic analysis and biochemically characterised. Immunoreactivity was assessed by blot (inhibitions) and RAST (inhibitions), and skin prick tests were performed with the isolated allergens.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">All subjects were polyallergic, sensitised and reactive to several additional foods and pollen. All patients were sensitised to grape LTP. A 28-kDa expansin, a 37.5-kDa polygalacturonase-inhibiting protein, a 39-kDa beta-1,3-glucanase and a 60-kDa protein were identified as minor grape allergens. Endochitinase and TLP did not play a role. Inhibition experiments revealed the possible cross-reactive role of LTP for clinical sensitivities to other LTP-containing plant foods, but also the involvement of cross-reactive carbohydrate determinants of minor allergens in IgE cross-reactivity.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">LTP is the major grape allergen, while additional minor allergens may contribute to clinical reactivity. Severe grape allergy presents in atopic patients who frequently react to other LTP-containing, plant-derived foods. The 'LTP syndrome' is the appropriate term to describe this condition.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vassilopoulou</LastName>
<ForeName>Emilia</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Allergy Research Centre, Second Pediatric Clinic, University of Athens, Athens, Greece. emi@allergy.gr</Affiliation>
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<Author ValidYN="Y"><LastName>Zuidmeer</LastName>
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<Author ValidYN="Y"><LastName>Akkerdaas</LastName>
<ForeName>Jaap</ForeName>
<Initials>J</Initials>
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<Author ValidYN="Y"><LastName>Tassios</LastName>
<ForeName>Ioannis</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rigby</LastName>
<ForeName>Neil R</ForeName>
<Initials>NR</Initials>
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<Author ValidYN="Y"><LastName>Mills</LastName>
<ForeName>E N Clare</ForeName>
<Initials>EN</Initials>
</Author>
<Author ValidYN="Y"><LastName>van Ree</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Saxoni-Papageorgiou</LastName>
<ForeName>Photini</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Papadopoulos</LastName>
<ForeName>Nikolaos G</ForeName>
<Initials>NG</Initials>
</Author>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D011852" MajorTopicYN="N">Radioallergosorbent Test</DescriptorName>
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<MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName>
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