Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.
Identifieur interne : 000086 ( PubMed/Curation ); précédent : 000085; suivant : 000087Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.
Auteurs : Eric Tielemans [France] ; Coralie Manavella [France] ; Martin Visser [Allemagne] ; S. Theodore Chester [États-Unis] ; Joseph Rosentel [États-Unis]Source :
- Veterinary parasitology [ 1873-2550 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Antiparasitic Agents (administration & dosage), Cat Diseases (drug therapy), Cats, Drug Combinations, Echinococcosis (drug therapy), Echinococcosis (veterinary), Echinococcus multilocularis, Female, Ivermectin (administration & dosage), Ivermectin (analogs & derivatives), Male, Methoprene (administration & dosage), Praziquantel (administration & dosage), Pyrazoles (administration & dosage), Random Allocation, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparasitic Agents, Ivermectin, Methoprene, Praziquantel, Pyrazoles.
- chemical , analogs & derivatives : Ivermectin.
- drug therapy : Cat Diseases, Echinococcosis.
- veterinary : Echinococcosis.
- Animals, Cats, Drug Combinations, Echinococcus multilocularis, Female, Male, Random Allocation, Treatment Outcome.
Abstract
Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis.
DOI: 10.1016/j.vetpar.2014.02.034
PubMed: 24703072
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Electronic address: eric.tielemans@merial.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea></affiliation></author><author><name sortKey="Manavella, Coralie" sort="Manavella, Coralie" uniqKey="Manavella C" first="Coralie" last="Manavella">Coralie Manavella</name><affiliation wicri:level="1"><nlm:affiliation>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Martin" sort="Visser, Martin" uniqKey="Visser M" first="Martin" last="Visser">Martin Visser</name><affiliation wicri:level="1"><nlm:affiliation>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf</wicri:regionArea></affiliation></author><author><name sortKey="Theodore Chester, S" sort="Theodore Chester, S" uniqKey="Theodore Chester S" first="S" last="Theodore Chester">S. 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Electronic address: eric.tielemans@merial.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea></affiliation></author><author><name sortKey="Manavella, Coralie" sort="Manavella, Coralie" uniqKey="Manavella C" first="Coralie" last="Manavella">Coralie Manavella</name><affiliation wicri:level="1"><nlm:affiliation>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea></affiliation></author><author><name sortKey="Visser, Martin" sort="Visser, Martin" uniqKey="Visser M" first="Martin" last="Visser">Martin Visser</name><affiliation wicri:level="1"><nlm:affiliation>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf</wicri:regionArea></affiliation></author><author><name sortKey="Theodore Chester, S" sort="Theodore Chester, S" uniqKey="Theodore Chester S" first="S" last="Theodore Chester">S. Theodore Chester</name><affiliation wicri:level="1"><nlm:affiliation>Merial Limited, Duluth, GA 30096, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merial Limited, Duluth, GA 30096</wicri:regionArea></affiliation></author><author><name sortKey="Rosentel, Joseph" sort="Rosentel, Joseph" uniqKey="Rosentel J" first="Joseph" last="Rosentel">Joseph Rosentel</name><affiliation wicri:level="1"><nlm:affiliation>Merial Limited, Duluth, GA 30096, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merial Limited, Duluth, GA 30096</wicri:regionArea></affiliation></author></analytic><series><title level="j">Veterinary parasitology</title><idno type="eISSN">1873-2550</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiparasitic Agents (administration & dosage)</term><term>Cat Diseases (drug therapy)</term><term>Cats</term><term>Drug Combinations</term><term>Echinococcosis (drug therapy)</term><term>Echinococcosis (veterinary)</term><term>Echinococcus multilocularis</term><term>Female</term><term>Ivermectin (administration & dosage)</term><term>Ivermectin (analogs & derivatives)</term><term>Male</term><term>Methoprene (administration & dosage)</term><term>Praziquantel (administration & dosage)</term><term>Pyrazoles (administration & dosage)</term><term>Random Allocation</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparasitic Agents</term><term>Ivermectin</term><term>Methoprene</term><term>Praziquantel</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cat Diseases</term><term>Echinococcosis</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Echinococcosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cats</term><term>Drug Combinations</term><term>Echinococcus multilocularis</term><term>Female</term><term>Male</term><term>Random Allocation</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24703072</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>07</Day></DateCreated><DateCompleted><Year>2014</Year><Month>06</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1873-2550</ISSN><JournalIssue CitedMedium="Internet"><Volume>202</Volume><Issue>1-2</Issue><PubDate><Year>2014</Year><Month>Apr</Month><Day>28</Day></PubDate></JournalIssue><Title>Veterinary parasitology</Title><ISOAbbreviation>Vet. 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This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis.</AbstractText><CopyrightInformation>Copyright © 2014 The Authors. Published by Elsevier B.V. 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