[Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat].
Identifieur interne : 000493 ( PubMed/Corpus ); précédent : 000492; suivant : 000494[Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat].
Auteurs : J. Blancou ; M. Artois ; B. Brochier ; I. Thomas ; P P Pastoret ; P. Desmettre ; B. Languet ; M P KiénySource :
- Annales de recherches veterinaires. Annals of veterinary research [ 0003-4193 ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Rabies Vaccines.
- prevention & control : Rabies.
- veterinary : Rabies.
- Administration, Oral, Animals, Animals, Wild, Cats, Dogs, Drug Evaluation, Foxes, Rabies virus, Recombinant Proteins, Vaccinia virus.
Abstract
One of the most promising ways to control rabies in wildlife seems to be the distribution of bait containing an anti-rabies vaccine. So far, the most widely used vaccines were modified live viruses (SAD strain or derivatives). Nevertheless, these strains retain some pathogenicity for non-target species. A novel vaccine was proposed consisting of genetically modified vaccinia virus (strain Copenhagen, thermosensitive ts 26) expressing the foreign glycoprotein G for the rabies virus (strain ERA). Different doses of this recombinant virus were administered orally to 59 foxes (Vulpes vulpes) and their antibodies were titrated before challenge. Foxes (8/8) resisted 1 month after vaccination with 10(7) plaque forming units (PFU), or 4/4 after 18 months. Seroconversion among dogs was 4/4 after vaccination with 10(9,6) PFU and 4/4 among cats after vaccination with 10(8) PFU. These dogs (4/4) and cats (3/4) resisted the challenge 2-3 months after vaccination. This vaccine thus appears to be potent and safe in these species. Its properties are discussed.
PubMed: 2751231
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pubmed:2751231Le document en format XML
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Thomas</name></author><author><name sortKey="Pastoret, P P" sort="Pastoret, P P" uniqKey="Pastoret P" first="P P" last="Pastoret">P P Pastoret</name></author><author><name sortKey="Desmettre, P" sort="Desmettre, P" uniqKey="Desmettre P" first="P" last="Desmettre">P. Desmettre</name></author><author><name sortKey="Languet, B" sort="Languet, B" uniqKey="Languet B" first="B" last="Languet">B. Languet</name></author><author><name sortKey="Kieny, M P" sort="Kieny, M P" uniqKey="Kieny M" first="M P" last="Kiény">M P Kiény</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2751231</idno><idno type="pmid">2751231</idno><idno type="wicri:Area/PubMed/Corpus">000493</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000493</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat].</title><author><name sortKey="Blancou, J" sort="Blancou, J" uniqKey="Blancou J" first="J" last="Blancou">J. Blancou</name><affiliation><nlm:affiliation>CNEVA, Laboratoire d'Etudes sur la Rage et la Pathologie des Animaux Sauvages, Malzéville, France.</nlm:affiliation></affiliation></author><author><name sortKey="Artois, M" sort="Artois, M" uniqKey="Artois M" first="M" last="Artois">M. Artois</name></author><author><name sortKey="Brochier, B" sort="Brochier, B" uniqKey="Brochier B" first="B" last="Brochier">B. Brochier</name></author><author><name sortKey="Thomas, I" sort="Thomas, I" uniqKey="Thomas I" first="I" last="Thomas">I. Thomas</name></author><author><name sortKey="Pastoret, P P" sort="Pastoret, P P" uniqKey="Pastoret P" first="P P" last="Pastoret">P P Pastoret</name></author><author><name sortKey="Desmettre, P" sort="Desmettre, P" uniqKey="Desmettre P" first="P" last="Desmettre">P. Desmettre</name></author><author><name sortKey="Languet, B" sort="Languet, B" uniqKey="Languet B" first="B" last="Languet">B. Languet</name></author><author><name sortKey="Kieny, M P" sort="Kieny, M P" uniqKey="Kieny M" first="M P" last="Kiény">M P Kiény</name></author></analytic><series><title level="j">Annales de recherches veterinaires. Annals of veterinary research</title><idno type="ISSN">0003-4193</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Wild</term><term>Cats</term><term>Dogs</term><term>Drug Evaluation</term><term>Foxes</term><term>Rabies (prevention & control)</term><term>Rabies (veterinary)</term><term>Rabies Vaccines (administration & dosage)</term><term>Rabies virus</term><term>Recombinant Proteins</term><term>Vaccinia virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rabies Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Wild</term><term>Cats</term><term>Dogs</term><term>Drug Evaluation</term><term>Foxes</term><term>Rabies virus</term><term>Recombinant Proteins</term><term>Vaccinia virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the most promising ways to control rabies in wildlife seems to be the distribution of bait containing an anti-rabies vaccine. So far, the most widely used vaccines were modified live viruses (SAD strain or derivatives). Nevertheless, these strains retain some pathogenicity for non-target species. A novel vaccine was proposed consisting of genetically modified vaccinia virus (strain Copenhagen, thermosensitive ts 26) expressing the foreign glycoprotein G for the rabies virus (strain ERA). Different doses of this recombinant virus were administered orally to 59 foxes (Vulpes vulpes) and their antibodies were titrated before challenge. Foxes (8/8) resisted 1 month after vaccination with 10(7) plaque forming units (PFU), or 4/4 after 18 months. Seroconversion among dogs was 4/4 after vaccination with 10(9,6) PFU and 4/4 among cats after vaccination with 10(8) PFU. These dogs (4/4) and cats (3/4) resisted the challenge 2-3 months after vaccination. This vaccine thus appears to be potent and safe in these species. Its properties are discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2751231</PMID><DateCreated><Year>1989</Year><Month>08</Month><Day>22</Day></DateCreated><DateCompleted><Year>1989</Year><Month>08</Month><Day>22</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-4193</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>2</Issue><PubDate><Year>1989</Year></PubDate></JournalIssue><Title>Annales de recherches veterinaires. Annals of veterinary research</Title><ISOAbbreviation>Ann. Rech. Vet.</ISOAbbreviation></Journal><ArticleTitle>[Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat].</ArticleTitle><Pagination><MedlinePgn>195-204</MedlinePgn></Pagination><Abstract><AbstractText>One of the most promising ways to control rabies in wildlife seems to be the distribution of bait containing an anti-rabies vaccine. So far, the most widely used vaccines were modified live viruses (SAD strain or derivatives). Nevertheless, these strains retain some pathogenicity for non-target species. A novel vaccine was proposed consisting of genetically modified vaccinia virus (strain Copenhagen, thermosensitive ts 26) expressing the foreign glycoprotein G for the rabies virus (strain ERA). Different doses of this recombinant virus were administered orally to 59 foxes (Vulpes vulpes) and their antibodies were titrated before challenge. Foxes (8/8) resisted 1 month after vaccination with 10(7) plaque forming units (PFU), or 4/4 after 18 months. Seroconversion among dogs was 4/4 after vaccination with 10(9,6) PFU and 4/4 among cats after vaccination with 10(8) PFU. These dogs (4/4) and cats (3/4) resisted the challenge 2-3 months after vaccination. This vaccine thus appears to be potent and safe in these species. Its properties are discussed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blancou</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CNEVA, Laboratoire d'Etudes sur la Rage et la Pathologie des Animaux Sauvages, Malzéville, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Artois</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Brochier</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Pastoret</LastName><ForeName>P P</ForeName><Initials>PP</Initials></Author><Author ValidYN="Y"><LastName>Desmettre</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Languet</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Kiény</LastName><ForeName>M P</ForeName><Initials>MP</Initials></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Innocuité et efficacité d'un vaccin antirabique recombinant des virus de la vaccine et de la rage administré par voie orale au renard, au chien et au chat.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Ann Rech Vet</MedlineTA><NlmUniqueID>1267230</NlmUniqueID><ISSNLinking>0003-4193</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011819">Rabies Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000835" MajorTopicYN="N">Animals, Wild</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004341" MajorTopicYN="N">Drug Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005589" MajorTopicYN="N">Foxes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011818" MajorTopicYN="N">Rabies</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011819" MajorTopicYN="N">Rabies Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011820" MajorTopicYN="Y">Rabies virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014616" MajorTopicYN="Y">Vaccinia virus</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2751231</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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