Effectiveness of cabergoline for termination of pregnancy in silver fox (Vulpes vulpes fulva).
Identifieur interne : 000320 ( PubMed/Corpus ); précédent : 000319; suivant : 000321Effectiveness of cabergoline for termination of pregnancy in silver fox (Vulpes vulpes fulva).
Auteurs : T. Lengwinat ; H H Meyer ; W. JöchleSource :
- Reproduction in domestic animals = Zuchthygiene [ 0936-6768 ] ; 2001.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Abortifacient Agents, Ergolines.
- chemical , blood : Progesterone, Prolactin.
- veterinary : Abortion, Induced.
- Abortion, Veterinary, Administration, Oral, Animals, Dose-Response Relationship, Drug, Female, Foxes, Pregnancy.
Abstract
Red foxes (Vulpes vulpes) are a major pest species in Europe and Australia. Traditional methods of control such as hunting or poisoning are no longer sufficient or feasible. As with domestic dogs and cats, prolactin (PRL) in the vixen is an essential luteotropin during the second half of gestation. Hence, PRL inhibitors such as cabergoline have been used to induce abortions. Eighteen mated silver fox vixens (three groups of six foxes each) were treated orally with a placebo of paraffin oil (I), or with 15 microg/kg cabergoline in feed once (11) or twice (III), on day 30 (I and II) or days 30 and 32 (III) post-coitum. Blood samples were taken prior to and after treatments and concentrations of PRL and progesterone (P4) were determined. Normal parturitions were observed in five of six, five of six and two of six vixens in groups I, II and III, respectively. In group III plasma concentrations of PRL and P4 decreased significantly but only temporarily. This drop in hormone concentrations was more pronounced in the vixens that did not carry to term. In conclusion, doses in excess of 15 microg/kg of cabergoline are likely to prevent the development of fetuses to term in pregnant vixens.
PubMed: 11885743
Links to Exploration step
pubmed:11885743Le document en format XML
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Jöchle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11885743</idno><idno type="pmid">11885743</idno><idno type="wicri:Area/PubMed/Corpus">000320</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000320</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effectiveness of cabergoline for termination of pregnancy in silver fox (Vulpes vulpes fulva).</title><author><name sortKey="Lengwinat, T" sort="Lengwinat, T" uniqKey="Lengwinat T" first="T" last="Lengwinat">T. Lengwinat</name><affiliation><nlm:affiliation>Institut für Zoo-und Wildtierforschung, Berlin, Germany. lengwinat@izw-berlin.de</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, H H" sort="Meyer, H H" uniqKey="Meyer H" first="H H" last="Meyer">H H Meyer</name></author><author><name sortKey="Jochle, W" sort="Jochle, W" uniqKey="Jochle W" first="W" last="Jöchle">W. Jöchle</name></author></analytic><series><title level="j">Reproduction in domestic animals = Zuchthygiene</title><idno type="ISSN">0936-6768</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abortifacient Agents (administration & dosage)</term><term>Abortion, Induced (veterinary)</term><term>Abortion, Veterinary</term><term>Administration, Oral</term><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Ergolines (administration & dosage)</term><term>Female</term><term>Foxes</term><term>Pregnancy</term><term>Progesterone (blood)</term><term>Prolactin (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Abortifacient Agents</term><term>Ergolines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Progesterone</term><term>Prolactin</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Abortion, Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abortion, Veterinary</term><term>Administration, Oral</term><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Foxes</term><term>Pregnancy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Red foxes (Vulpes vulpes) are a major pest species in Europe and Australia. Traditional methods of control such as hunting or poisoning are no longer sufficient or feasible. As with domestic dogs and cats, prolactin (PRL) in the vixen is an essential luteotropin during the second half of gestation. Hence, PRL inhibitors such as cabergoline have been used to induce abortions. Eighteen mated silver fox vixens (three groups of six foxes each) were treated orally with a placebo of paraffin oil (I), or with 15 microg/kg cabergoline in feed once (11) or twice (III), on day 30 (I and II) or days 30 and 32 (III) post-coitum. Blood samples were taken prior to and after treatments and concentrations of PRL and progesterone (P4) were determined. Normal parturitions were observed in five of six, five of six and two of six vixens in groups I, II and III, respectively. In group III plasma concentrations of PRL and P4 decreased significantly but only temporarily. This drop in hormone concentrations was more pronounced in the vixens that did not carry to term. In conclusion, doses in excess of 15 microg/kg of cabergoline are likely to prevent the development of fetuses to term in pregnant vixens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11885743</PMID><DateCreated><Year>2002</Year><Month>03</Month><Day>11</Day></DateCreated><DateCompleted><Year>2002</Year><Month>04</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0936-6768</ISSN><JournalIssue CitedMedium="Print"><Volume>36</Volume><Issue>5</Issue><PubDate><Year>2001</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Reproduction in domestic animals = Zuchthygiene</Title><ISOAbbreviation>Reprod. Domest. Anim.</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of cabergoline for termination of pregnancy in silver fox (Vulpes vulpes fulva).</ArticleTitle><Pagination><MedlinePgn>257-60</MedlinePgn></Pagination><Abstract><AbstractText>Red foxes (Vulpes vulpes) are a major pest species in Europe and Australia. Traditional methods of control such as hunting or poisoning are no longer sufficient or feasible. As with domestic dogs and cats, prolactin (PRL) in the vixen is an essential luteotropin during the second half of gestation. Hence, PRL inhibitors such as cabergoline have been used to induce abortions. Eighteen mated silver fox vixens (three groups of six foxes each) were treated orally with a placebo of paraffin oil (I), or with 15 microg/kg cabergoline in feed once (11) or twice (III), on day 30 (I and II) or days 30 and 32 (III) post-coitum. Blood samples were taken prior to and after treatments and concentrations of PRL and progesterone (P4) were determined. Normal parturitions were observed in five of six, five of six and two of six vixens in groups I, II and III, respectively. In group III plasma concentrations of PRL and P4 decreased significantly but only temporarily. This drop in hormone concentrations was more pronounced in the vixens that did not carry to term. In conclusion, doses in excess of 15 microg/kg of cabergoline are likely to prevent the development of fetuses to term in pregnant vixens.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lengwinat</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institut für Zoo-und Wildtierforschung, Berlin, Germany. lengwinat@izw-berlin.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>H H</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Jöchle</LastName><ForeName>W</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Reprod Domest Anim</MedlineTA><NlmUniqueID>9015668</NlmUniqueID><ISSNLinking>0936-6768</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000019">Abortifacient Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004873">Ergolines</NameOfSubstance></Chemical><Chemical><RegistryNumber>4G7DS2Q64Y</RegistryNumber><NameOfSubstance UI="D011374">Progesterone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-62-4</RegistryNumber><NameOfSubstance UI="D011388">Prolactin</NameOfSubstance></Chemical><Chemical><RegistryNumber>LL60K9J05T</RegistryNumber><NameOfSubstance UI="C047047">cabergoline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000019" MajorTopicYN="N">Abortifacient Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000028" MajorTopicYN="N">Abortion, Induced</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000034" MajorTopicYN="Y">Abortion, Veterinary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004873" MajorTopicYN="N">Ergolines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005589" MajorTopicYN="Y">Foxes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011374" MajorTopicYN="N">Progesterone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011388" MajorTopicYN="N">Prolactin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>3</Month><Day>12</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>4</Month><Day>16</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>3</Month><Day>12</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11885743</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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