Using the genetics of Echinococcus multilocularis to trace the history of expansion from an endemic area.
Identifieur interne : 000090 ( PubMed/Corpus ); précédent : 000089; suivant : 000091Using the genetics of Echinococcus multilocularis to trace the history of expansion from an endemic area.
Auteurs : G. Umhang ; J. Knapp ; V. Hormaz ; F. Raoul ; F. BouéSource :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-7257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : DNA, Helminth.
- geographic : France.
- classification : Echinococcus multilocularis.
- genetics : Echinococcus multilocularis.
- isolation & purification : Echinococcus multilocularis.
- parasitology : Echinococcosis, Foxes.
- transmission : Echinococcosis.
- Animals, Genetic Variation.
Abstract
Alveolar echinococcosis, caused by the cestode Echinococcus multilocularis, is the most serious parasitic disease for humans in Europe, with a sylvatic life cycle generally between small rodents and red foxes. General expansion of the range of E. multilocularis has been observed across Europe over the last 15years. In France, a westward spread of the known endemic areas of the parasite was described recently. For genotyping, the microsatellite EmsB was used to trace expansion in five French areas. A total of 22 EmsB profiles were identified, with five similar to those previously described in other parts of Europe. An imbalance of genetic diversity was observed between the five areas which also revealed their interconnection with the presence of common profiles, notably the two main profiles both present in all regions except one in the North. These two findings are similar to those described at the European level, highlighting transmission of the parasite by a mainland-island system. A spatio-temporal scenario of the expansion of E. multilocularis can be proposed with spread from the French historical focus in eastern France to the Lorraine, the Champagne-Ardenne and finally the North, while simultaneously another expansion has occurred from the historical focus into the West. The colonization by the parasite into the West and North areas from the historical focus was probably due to the migration of foxes several decades ago. Recent detection of the parasite in new endemic "départements" may be due to more active research rather than a recent spread of the parasite. Regarding the numerous data obtained by the different EmsB analyses, principally across Europe, centralization of all the profiles described in a public databank appears necessary in order to obtain a precise understanding of transmission of the parasite from one country to another.
DOI: 10.1016/j.meegid.2014.01.018
PubMed: 24468327
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pubmed:24468327Le document en format XML
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Hormaz</name><affiliation><nlm:affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</nlm:affiliation></affiliation></author><author><name sortKey="Raoul, F" sort="Raoul, F" uniqKey="Raoul F" first="F" last="Raoul">F. Raoul</name><affiliation><nlm:affiliation>Chrono-environment Laboratory, UMR UFC/CNRS 6249 usc INRA, University of Franche-Comte, Place Leclerc, 25030 Besancon Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boue, F" sort="Boue, F" uniqKey="Boue F" first="F" last="Boué">F. Boué</name><affiliation><nlm:affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24468327</idno><idno type="pmid">24468327</idno><idno type="doi">10.1016/j.meegid.2014.01.018</idno><idno type="wicri:Area/PubMed/Corpus">000090</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000090</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Using the genetics of Echinococcus multilocularis to trace the history of expansion from an endemic area.</title><author><name sortKey="Umhang, G" sort="Umhang, G" uniqKey="Umhang G" first="G" last="Umhang">G. Umhang</name><affiliation><nlm:affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France. Electronic address: gerald.umhang@anses.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Knapp, J" sort="Knapp, J" uniqKey="Knapp J" first="J" last="Knapp">J. Knapp</name><affiliation><nlm:affiliation>Chrono-environment Laboratory, UMR UFC/CNRS 6249 usc INRA, University of Franche-Comte, Place Leclerc, 25030 Besancon Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hormaz, V" sort="Hormaz, V" uniqKey="Hormaz V" first="V" last="Hormaz">V. Hormaz</name><affiliation><nlm:affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</nlm:affiliation></affiliation></author><author><name sortKey="Raoul, F" sort="Raoul, F" uniqKey="Raoul F" first="F" last="Raoul">F. Raoul</name><affiliation><nlm:affiliation>Chrono-environment Laboratory, UMR UFC/CNRS 6249 usc INRA, University of Franche-Comte, Place Leclerc, 25030 Besancon Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boue, F" sort="Boue, F" uniqKey="Boue F" first="F" last="Boué">F. Boué</name><affiliation><nlm:affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</title><idno type="eISSN">1567-7257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>DNA, Helminth (analysis)</term><term>Echinococcosis (parasitology)</term><term>Echinococcosis (transmission)</term><term>Echinococcus multilocularis (classification)</term><term>Echinococcus multilocularis (genetics)</term><term>Echinococcus multilocularis (isolation & purification)</term><term>Foxes (parasitology)</term><term>France</term><term>Genetic Variation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Helminth</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Echinococcus multilocularis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Echinococcus multilocularis</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Echinococcus multilocularis</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Echinococcosis</term><term>Foxes</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Echinococcosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Variation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alveolar echinococcosis, caused by the cestode Echinococcus multilocularis, is the most serious parasitic disease for humans in Europe, with a sylvatic life cycle generally between small rodents and red foxes. General expansion of the range of E. multilocularis has been observed across Europe over the last 15years. In France, a westward spread of the known endemic areas of the parasite was described recently. For genotyping, the microsatellite EmsB was used to trace expansion in five French areas. A total of 22 EmsB profiles were identified, with five similar to those previously described in other parts of Europe. An imbalance of genetic diversity was observed between the five areas which also revealed their interconnection with the presence of common profiles, notably the two main profiles both present in all regions except one in the North. These two findings are similar to those described at the European level, highlighting transmission of the parasite by a mainland-island system. A spatio-temporal scenario of the expansion of E. multilocularis can be proposed with spread from the French historical focus in eastern France to the Lorraine, the Champagne-Ardenne and finally the North, while simultaneously another expansion has occurred from the historical focus into the West. The colonization by the parasite into the West and North areas from the historical focus was probably due to the migration of foxes several decades ago. Recent detection of the parasite in new endemic "départements" may be due to more active research rather than a recent spread of the parasite. Regarding the numerous data obtained by the different EmsB analyses, principally across Europe, centralization of all the profiles described in a public databank appears necessary in order to obtain a precise understanding of transmission of the parasite from one country to another.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24468327</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>03</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>03</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1567-7257</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</Title><ISOAbbreviation>Infect. Genet. Evol.</ISOAbbreviation></Journal><ArticleTitle>Using the genetics of Echinococcus multilocularis to trace the history of expansion from an endemic area.</ArticleTitle><Pagination><MedlinePgn>142-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.meegid.2014.01.018</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1567-1348(14)00021-5</ELocationID><Abstract><AbstractText>Alveolar echinococcosis, caused by the cestode Echinococcus multilocularis, is the most serious parasitic disease for humans in Europe, with a sylvatic life cycle generally between small rodents and red foxes. General expansion of the range of E. multilocularis has been observed across Europe over the last 15years. In France, a westward spread of the known endemic areas of the parasite was described recently. For genotyping, the microsatellite EmsB was used to trace expansion in five French areas. A total of 22 EmsB profiles were identified, with five similar to those previously described in other parts of Europe. An imbalance of genetic diversity was observed between the five areas which also revealed their interconnection with the presence of common profiles, notably the two main profiles both present in all regions except one in the North. These two findings are similar to those described at the European level, highlighting transmission of the parasite by a mainland-island system. A spatio-temporal scenario of the expansion of E. multilocularis can be proposed with spread from the French historical focus in eastern France to the Lorraine, the Champagne-Ardenne and finally the North, while simultaneously another expansion has occurred from the historical focus into the West. The colonization by the parasite into the West and North areas from the historical focus was probably due to the migration of foxes several decades ago. Recent detection of the parasite in new endemic "départements" may be due to more active research rather than a recent spread of the parasite. Regarding the numerous data obtained by the different EmsB analyses, principally across Europe, centralization of all the profiles described in a public databank appears necessary in order to obtain a precise understanding of transmission of the parasite from one country to another.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Umhang</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France. Electronic address: gerald.umhang@anses.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knapp</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Chrono-environment Laboratory, UMR UFC/CNRS 6249 usc INRA, University of Franche-Comte, Place Leclerc, 25030 Besancon Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hormaz</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raoul</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Chrono-environment Laboratory, UMR UFC/CNRS 6249 usc INRA, University of Franche-Comte, Place Leclerc, 25030 Besancon Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boué</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>ANSES, Nancy Laboratory for Rabies and Wildlife, National Reference Laboratory for Echinococcus spp., Wildlife Eco-epidemiology and Surveillance Unit, 54220 Malzéville, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Infect Genet Evol</MedlineTA><NlmUniqueID>101084138</NlmUniqueID><ISSNLinking>1567-1348</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018509">DNA, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018509" MajorTopicYN="N">DNA, Helminth</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004443" MajorTopicYN="N">Echinococcosis</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048210" MajorTopicYN="N">Echinococcus multilocularis</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005589" MajorTopicYN="N">Foxes</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Echinococcus multilocularis</Keyword><Keyword MajorTopicYN="N">EmsB microsatellite</Keyword><Keyword MajorTopicYN="N">France</Keyword><Keyword MajorTopicYN="N">Genetic diversity</Keyword><Keyword MajorTopicYN="N">Parasite expansion</Keyword><Keyword MajorTopicYN="N">Red fox</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>01</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24468327</ArticleId><ArticleId IdType="pii">S1567-1348(14)00021-5</ArticleId><ArticleId IdType="doi">10.1016/j.meegid.2014.01.018</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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