RenardV1, PascalFrancis, Checkpoint, bibRecord, 000030

Efficacy of a Square Presentation of V-RG Vaccine Baits in Red Fox, Domestic Dog and Raccoon Dog

Identifieur interne : 000030 ( PascalFrancis/Checkpoint ); précédent : 000029; suivant : 000031

Efficacy of a Square Presentation of V-RG Vaccine Baits in Red Fox, Domestic Dog and Raccoon Dog

Auteurs : F. Cliquet [France] ; A. L. Guiot [France] ; C. Schumacher [France] ; J. Maki [France] ; N. Cael [France] ; J. Barrat [France]

Source :

Developments in biologicals [ 1424-6074 ] ; 2008.

RBID : Pascal:08-0492980

Descripteurs français

Pascal (Inist)
- Chien, Virus rage, Vulpes vulpes, Efficacité, Vaccin, Renard, Appât, Prévention, Immunoprophylaxie, Appétence, Forme pharmaceutique, Rage.
Wicri :
- topic : Vaccin, Rage.

English descriptors

KwdEn :
- Appetitivity, Bait, Dog, Dosage form, Efficiency, Fox, Immunoprophylaxis, Prevention, Rabies, Rabies virus, Vaccine, Vulpes vulpes.

Abstract

Oral vaccination programmes conducted in rabies infected countries from Eastern Europe and Eurasia should not be restricted to foxes but should target other major rabies vectors such as dogs and raccoon dogs as well. The objective of this experimental trial was to assess the protection induced by the vaccine by challenging these different species, which had been previously vaccinated intramuscularly with the square V-RG baits (produced in the US). Different parameters were evaluated such as attractiveness of the baits and induction of neutralising antibodies as an indicator for immunogenicity and protection after rabies challenge. The acceptability of the square bait was satisfactory in dogs, foxes and raccoon dogs, confirming previous laboratory and field studies conducted with the rectangular baits. Only one vaccinated dog out of nine seroconverted after vaccination and among them one dog died of rabies. Eight often vaccinated foxes seroconverted after vaccination and survived the rabies challenge. All vaccinated raccoon dogs seroconverted after challenge and all survived the challenge. These trials demonstrated that the square presentation of the V-RG vaccine was attractive, immunogenic and efficacious.

Affiliations:

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Pascal:08-0492980

Le document en format XML

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<front><div type="abstract" xml:lang="en">Oral vaccination programmes conducted in rabies infected countries from Eastern Europe and Eurasia should not be restricted to foxes but should target other major rabies vectors such as dogs and raccoon dogs as well. The objective of this experimental trial was to assess the protection induced by the vaccine by challenging these different species, which had been previously vaccinated intramuscularly with the square V-RG baits (produced in the US). Different parameters were evaluated such as attractiveness of the baits and induction of neutralising antibodies as an indicator for immunogenicity and protection after rabies challenge. The acceptability of the square bait was satisfactory in dogs, foxes and raccoon dogs, confirming previous laboratory and field studies conducted with the rectangular baits. Only one vaccinated dog out of nine seroconverted after vaccination and among them one dog died of rabies. Eight often vaccinated foxes seroconverted after vaccination and survived the rabies challenge. All vaccinated raccoon dogs seroconverted after challenge and all survived the challenge. These trials demonstrated that the square presentation of the V-RG vaccine was attractive, immunogenic and efficacious.</div>
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<fC07 i1="03" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Lyssavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lyssavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Lyssavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Rhabdoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Rhabdoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Rhabdoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Vétérinaire</s0>
<s5>13</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Veterinary</s0>
<s5>13</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Veterinario</s0>
<s5>13</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>322</s1>
</fN21>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>Joint OIE/WHO/EU International Conference</s1>
<s3>Paris FRA</s3>
<s4>2007-05-27</s4>
</fA30>
</pR>
</standard>
</inist>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lyon</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Cliquet, F" sort="Cliquet, F" uniqKey="Cliquet F" first="F." last="Cliquet">F. Cliquet</name>
</noRegion>
<name sortKey="Barrat, J" sort="Barrat, J" uniqKey="Barrat J" first="J." last="Barrat">J. Barrat</name>
<name sortKey="Cael, N" sort="Cael, N" uniqKey="Cael N" first="N." last="Cael">N. Cael</name>
<name sortKey="Guiot, A L" sort="Guiot, A L" uniqKey="Guiot A" first="A. L." last="Guiot">A. L. Guiot</name>
<name sortKey="Maki, J" sort="Maki, J" uniqKey="Maki J" first="J." last="Maki">J. Maki</name>
<name sortKey="Schumacher, C" sort="Schumacher, C" uniqKey="Schumacher C" first="C." last="Schumacher">C. Schumacher</name>
</country>
</tree>
</affiliations>
</record>

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Efficacy of a Square Presentation of V-RG Vaccine Baits in Red Fox, Domestic Dog and Raccoon Dog

Efficacy of a Square Presentation of V-RG Vaccine Baits in Red Fox, Domestic Dog and Raccoon Dog

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