Characterization of a double avirulent mutant of rabies virus and its potency as a vaccine, live or inactivated
Identifieur interne : 001608 ( Main/Exploration ); précédent : 001607; suivant : 001609Characterization of a double avirulent mutant of rabies virus and its potency as a vaccine, live or inactivated
Auteurs : Ramkrisna Tidke [France] ; Christophe Préhaud [France] ; Patrice Coulon [France] ; Jean Blancou [France] ; Anne Flamand [France]Source :
- Vaccine [ 0264-410X ] ; 1987.
Abstract
A strain bearing two mutations which abolish the virulence for adult animals after intracerebral or intramuscular inoculation has been constructed from the CVS strain of rabies virus. This apathogenic phenotype is stable after three successive passages of the double mutant in suckling mice brain. Trials of vaccination performed on mice in parallel with the double mutant and CVS both inactivated with β-propiolactone indicate that the mutant is at least as efficient as CVS. This strain has also been found to be efficient as a live virus vaccine.
Url:
DOI: 10.1016/0264-410X(87)90106-X
Affiliations:
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when="1987">1987</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="229">229</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0264-410X</idno></series><idno type="istex">84F5681055D735082CAC20F39F068452BF1A6600</idno><idno type="DOI">10.1016/0264-410X(87)90106-X</idno><idno type="PII">0264-410X(87)90106-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A strain bearing two mutations which abolish the virulence for adult animals after intracerebral or intramuscular inoculation has been constructed from the CVS strain of rabies virus. This apathogenic phenotype is stable after three successive passages of the double mutant in suckling mice brain. Trials of vaccination performed on mice in parallel with the double mutant and CVS both inactivated with β-propiolactone indicate that the mutant is at least as efficient as CVS. This strain has also been found to be efficient as a live virus vaccine.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li><li>Île-de-France</li></region><settlement><li>Gif sur Yvette</li><li>Malzéville</li></settlement></list><tree><country name="France"><region name="Grand Est"><name sortKey="Tidke, Ramkrisna" sort="Tidke, Ramkrisna" uniqKey="Tidke R" first="Ramkrisna" last="Tidke">Ramkrisna Tidke</name></region><name sortKey="Blancou, Jean" sort="Blancou, Jean" uniqKey="Blancou J" first="Jean" last="Blancou">Jean Blancou</name><name sortKey="Coulon, Patrice" sort="Coulon, Patrice" uniqKey="Coulon P" first="Patrice" last="Coulon">Patrice Coulon</name><name sortKey="Flamand, Anne" sort="Flamand, Anne" uniqKey="Flamand A" first="Anne" last="Flamand">Anne Flamand</name><name sortKey="Prehaud, Christophe" sort="Prehaud, Christophe" uniqKey="Prehaud C" first="Christophe" last="Préhaud">Christophe Préhaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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