Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination.
Identifieur interne : 000154 ( Main/Exploration ); précédent : 000153; suivant : 000155Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination.
Auteurs : Florence Cliquet [France] ; Emmanuelle Robardet ; Evelyne Picard MeyerSource :
- Antiviral research [ 1872-9096 ] ; 2013.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Animals, Wild (immunology), Animals, Wild (virology), Europe, Molecular Sequence Data, Phylogeny, Rabies (immunology), Rabies (prevention & control), Rabies (veterinary), Rabies (virology), Rabies Vaccines (administration & dosage), Rabies Vaccines (genetics), Rabies Vaccines (immunology), Rabies virus (classification), Rabies virus (genetics), Rabies virus (immunology), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology).
- MESH :
- chemical , administration & dosage : Rabies Vaccines, Vaccines, Attenuated.
- chemical , genetics : Rabies Vaccines, Vaccines, Attenuated.
- chemical , immunology : Rabies Vaccines, Vaccines, Attenuated.
- geographic : Europe.
- classification : Rabies virus.
- genetics : Rabies virus.
- immunology : Animals, Wild, Rabies, Rabies virus.
- prevention & control : Rabies.
- veterinary : Rabies.
- virology : Animals, Wild, Rabies.
- Administration, Oral, Animals, Molecular Sequence Data, Phylogeny.
Abstract
In Europe, the main reservoir and vector of rabies has been the red fox (Vulpes vulpes). Oral immunization of foxes with live vaccines, using attenuated rabies strains (SAD B19, SAD Bern), apathogenic mutants of an attenuated strain (SAG2) and the vaccinia-rabies glycoprotein recombinant virus vaccine (V-RG), has been shown to be the most effective method for the control and elimination of rabies. Among all vaccines currently used for wildlife oral vaccination, one vaccine (marketed as SAD Bern strain) has been widely used in Europe since 1992 with the distribution of 17million of baits in 2011. Because of the potential environmental safety risk of a live virus which could revert to virulence, the full genome sequencing of this vaccine was undertaken and the sequence was characterized and compared with those of referenced rabies viruses. The vaccine showed higher similarity to the strains belonging to the SAD B19 vaccine virus strains than to the SAD Bern vaccines. This study is the first one reporting on virus strain identity changes in this attenuated vaccine.
DOI: 10.1016/j.antiviral.2013.07.012
PubMed: 23899697
Affiliations:
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Le document en format XML
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Electronic address: florence.cliquet@anses.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Nancy Laboratory for Rabies and Wildlife, European Union Reference Laboratory for Rabies, European Union Reference Laboratory for Rabies Serology, WHO Collaborating Centre for Research & Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Technopôle agricole et vétérinaire, BP 40 009, 54 220 Malzéville Cedex</wicri:regionArea><wicri:noRegion>54 220 Malzéville Cedex</wicri:noRegion><wicri:noRegion>54 220 Malzéville Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Robardet, Emmanuelle" sort="Robardet, Emmanuelle" uniqKey="Robardet E" first="Emmanuelle" last="Robardet">Emmanuelle Robardet</name></author><author><name sortKey="Picard Meyer, Evelyne" sort="Picard Meyer, Evelyne" uniqKey="Picard Meyer E" first="Evelyne" last="Picard Meyer">Evelyne Picard Meyer</name></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Wild (immunology)</term><term>Animals, Wild (virology)</term><term>Europe</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Rabies (immunology)</term><term>Rabies (prevention & control)</term><term>Rabies (veterinary)</term><term>Rabies (virology)</term><term>Rabies Vaccines (administration & dosage)</term><term>Rabies Vaccines (genetics)</term><term>Rabies Vaccines (immunology)</term><term>Rabies virus (classification)</term><term>Rabies virus (genetics)</term><term>Rabies virus (immunology)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Animals, Wild</term><term>Rabies</term><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animals, Wild</term><term>Rabies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Molecular Sequence Data</term><term>Phylogeny</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Europe, the main reservoir and vector of rabies has been the red fox (Vulpes vulpes). Oral immunization of foxes with live vaccines, using attenuated rabies strains (SAD B19, SAD Bern), apathogenic mutants of an attenuated strain (SAG2) and the vaccinia-rabies glycoprotein recombinant virus vaccine (V-RG), has been shown to be the most effective method for the control and elimination of rabies. Among all vaccines currently used for wildlife oral vaccination, one vaccine (marketed as SAD Bern strain) has been widely used in Europe since 1992 with the distribution of 17million of baits in 2011. Because of the potential environmental safety risk of a live virus which could revert to virulence, the full genome sequencing of this vaccine was undertaken and the sequence was characterized and compared with those of referenced rabies viruses. The vaccine showed higher similarity to the strains belonging to the SAD B19 vaccine virus strains than to the SAD Bern vaccines. This study is the first one reporting on virus strain identity changes in this attenuated vaccine.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Picard Meyer, Evelyne" sort="Picard Meyer, Evelyne" uniqKey="Picard Meyer E" first="Evelyne" last="Picard Meyer">Evelyne Picard Meyer</name><name sortKey="Robardet, Emmanuelle" sort="Robardet, Emmanuelle" uniqKey="Robardet E" first="Emmanuelle" last="Robardet">Emmanuelle Robardet</name></noCountry><country name="France"><noRegion><name sortKey="Cliquet, Florence" sort="Cliquet, Florence" uniqKey="Cliquet F" first="Florence" last="Cliquet">Florence Cliquet</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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